Intralipid blocks the entry of the SARS-Cov2/COVID/19 virus into cells by maintaining receptor a leucine-rich repeat containing 15 (LRRC15), an angiotensin-converting enzyme 2 receptor competitor.

Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the complex pathology of the virus, which extends beyond respiratory symptoms to include multisystem inflammatory syndrome (MIS). This review explores the role of Acute Vascular Distress Syndrome (AVDS) in the development of MIS in both adults (MIS-A) and children (MIS-C), providing a comprehensive overview of modern research and treatment approaches for severe coronavirus infections. Methods and Materials: This review synthesizes findings from multiple studies and clinical reports to analyze the mechanisms by which SARS-CoV-2 induces AVDS and subsequently MIS. Key materials include molecular and cellular research data, clinical case studies, and treatment protocols. Diagnostic tools such as PCR and serological testing, as well as various biomarkers like neurofilament light chain and galectin-3, are discussed to elucidate their roles in identifying and managing severe COVID-19 cases. Results: The interaction between SARS-CoV-2 and host endothelial cells, mediated by ACE2 receptors, triggers a cascade of inflammatory responses leading to AVDS. This syndrome is characterized by severe endothelial dysfunction, cytokine storms, and mitochondrial distress, which collectively contribute to the pathogenesis of MIS. Clinical evidence indicates that AVDS is a critical factor in the severity of COVID-19, with widespread implications for multiple organ systems, including the central and peripheral nervous systems. Conclusion: Understanding the role of AVDS in MIS development offers valuable insights into the pathophysiology of severe COVID-19. Effective management requires a multifaceted approach, combining antiviral therapies, immunomodulators, and supportive treatments like extracorporeal membrane oxygenation (ECMO). Future research should focus on targeted therapies to mitigate endothelial damage and improve patient outcomes in critical COVID-19 cases.

Section: Disruption Of Mitochondrial Ca+2 Homeostasis Inflammatory Du...mentioning

confidence: 99%

Section: Multi-organ Supportive Therapy (Most) Extracorporeal Life Su...mentioning

confidence: 99%

Section: Multi-organ Supportive Therapy (Most) Extracorporeal Life Su...mentioning

confidence: 99%

Section: Fractal Signatures In Thementioning

confidence: 99%

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Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus

Vasilieva,

Vasiliev

2024

“…Considering maternal mortality in state-of-the-art clinics and sophisticated methods of treatment and diagnosis, the human factor of the doctor and the available methods of treatment and diagnosis remained a priority in reducing and even eliminating obstetric mortality. The of success since the last century as in many other previously published works, and represented at international congresses in the Republic of Moldova, Romania, Spain, the Netherlands, Russia and others, where decrease in the increased marker of tissue hypoxia pCO2> (AV -gap) in microcirculatorymitochondrial distress syndrome in critical obstetrics is achieved by complex methods of recruiting microcirculatory-mitochondrial distress syndrome, contributed to the absence of maternal mortality over 40 years of work in critical obstetrics is presented as a brilliant proof of an affordable model in any medical institution that finds itself next to a dying woman in labor [24][25][26][27][28][29][30][31][32][33][34][35][36].…”

Section: Academician Gh Ghidirim Materialized Quality Management In T...mentioning

confidence: 99%

Total Quality Management as Predictor of Artificial Intelligence Ensures Competitive Marketing

Vasilieva,

Visnevchi,

Vasilieva

et al. 2023

In the modern world Total Quality Management (TQM) respecting the past ensures the triumph of the future and Artificial Intelligence. Fulfilling the absence in the universal medical journal of multi-organ supportive therapy (MOST) replacement models of the central nervous system, immune and energy system functions, have been completed by describing extracorporeal and intracorporeal prosthetics of immune and energy system functions. Prosthetics, assistive support, and replacement of nervous system function contributed to the foundation of Artificial Intelligence (AI) and the creation of the robot as an intellect-technocrat combination. Using the Da Vinci robot with four arms, surgeons in Spain performed a lung transplant [3], relevant and timely also in the complications of COVID-19 SARS-CoV-2. As a result, the robot reduced the discrepancy between the predominance of the human and technocratic intellectual factors in the creation of the product useful to humanity. At the foundation of AI is TQM recognized by the scientific community of the modern world and in the context of alternative medicine models as a promoter of science. Thanks to the US development over 40 years of transgenic pig organ transplantation, as a model conceived in Moldova (1984), as an alternative to human donor organs. The prized TQM medicine is successfully assimilated by competitive marketing, in which AI is already included, with an essential social financial role. IA was supported by Antonio Guterres, Secretary General of the United Nations, Ursula von der Leyen, President of the European Commission. Thus AI has been considered at the level of the United Nations, the European Union, Japan, China and others. The head of the European Commission, Ursula von der Leyen from Great Britain at the First AI Safety Summit in the world, named 4 conditions for ensuring safety in the use of AI. 1) A thriving and independent scientific community equipped to evaluate AI systems, with funding and access to the best supercomputers; 2) Development of internationally recognized procedure and standards for AI safety testing. 3) A standard procedure whereby every significant incident caused by errors or misuse of AI is reported and accounted for. 4) Establishment of a reliable international notification system.

Lipid Therapy for Dyslipidemic Disorders Activates 21st Century Nano Antioxidant Hydrogen as a Potential Anti-COVID-19 Agent: Review

Vasilieva,

Vasiliev

2023

According to the World Health Organization (WHO), coronavirus infection (COVID-19, (COronaVIrus Disease 2019) is an infectious disease caused by the SARS-CoV-2 virus [1]. SARS-CoV-2 virus, Severe Acute Respiratory Syndrome-related coronavirus 2. Initially considered pulmonary - respiratory pathology, then it turned out to be poly-systemic, with multi-inflammation of many other organs, and central nervous system. Multisystem inflammatory syndrome in adults (MIS-A) [2], SARS-CoV-2 liver infection [3]. In pediatrics Multisystem inflammatory syndrome in children (MIS-C) or PMIS-TS (Pediatric MIS temporarily associated with SARS-CoV-2 infection) [4,5], SARS-COV-2/ COVID-19 in children induce Kawasaki-Like Disease [6]. Neurological manifestations [7], recurrence of COVID-19 infection with meningitis without pulmonary involvement [8]. Brain damage in COVID is primarily neurological, as a material signaling pathway of inflammatory COVID-infection of cerebral vessels. This is important, from the release of these patients, from additional stress, suffering, stigmatization in society, their isolation, intimidation, coercion (bullying) with violation and restriction of their rights. Since, concomitantly with inflammatory lesions of many organs, cognitive deficits are a component of the post-acute consequences of COVID-19 (PASC), where the role of the kynurenine pathway is significant with temporary cognitive impairment [9]. The main pathway for the breakdown of tryptophan is an amino acid, without which the synthesis of serotonin is impossible, which controls the cycles of sleep and wakefulness, which is the precursor of the sleep hormone melatonin In patients with COVID-19, an imbalance of T-helpers 1 and 2 leads to a cytokine storm that can contribute to myocardial damage [10]. MIS is conditioned caused by immunocompromising (IC) CHAOS - [C]ardiovascular Compromise: shock; [H]omeostasis; [A]poptosis; [O]rgan Dysfunction; [S]uppression of the Immune System with the development of Systemic inflammatory response syndrome (SIRS) and Multiple Organ Dysfunction Syndrome (MODS) [11,12]. With pronounced multiple and other symptoms: Electro - Ion Membrane Distress Syndrome (Syndrome Maria & Irina Vasilieva) [13,14] with membrane manifestations of electrical storm or electromembrane paralysis; Capillary Leak Syndrome; Microcirculatory-Mitochondrial Distress Syndrom [15,16]. Also described: Overlap mechanisms of transient global amnesia and COVID-19 infection [17]; Hypokalemia-stroke mimic [18]; Differential diagnosis of cacosmia and dysgeusia in COVID-19 pandemic [19].