Intraluminal “balloonless” air tonometry: A new method for determination of gastrointestinal mucosal carbon dioxide tension

Salzman, Andrew L.; Strong, Kevin E.; Wang, H; Wollert, P S; VanderMeer, Thomas J.; Fink, Mitchell P.

doi:10.1097/00003246-199401000-00024

Cited by 56 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, in an experimental pig model, a close correlation between PtCO 2 and PaCO 2 was noted during the induction of gradual respiratory acidosis independently of any variation in mucosal perfusion [11]. The important finding of the study is that, in a situation of varying PaCO 2 , the P gap CO 2 remains unaffected as long as there is no concomitant change in CO. During the ªhyperventilation phaseº, PaCO 2 and PtCO 2 paralleled so that the P gap CO 2 was poorly affected by changes in ventilatory settings.…”

Section: Discussionmentioning

confidence: 62%

Influence of alveolar ventilation changes on calculated gastric intramucosal pH and gastric-arterial PCO2 difference

Bernardin¹,

Lucas²,

Hyvernat³

et al. 1999

Intensive Care Med

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 62%

Influence of alveolar ventilation changes on calculated gastric intramucosal pH and gastric-arterial PCO2 difference

Bernardin¹,

Lucas²,

Hyvernat³

et al. 1999

Intensive Care Med

View full text Add to dashboard Cite

show abstract

“…As these patients were haemodynamically stable, the gastric carbon-dioxide levels closely followed systemic arterial carbon-dioxide values. This observation was confirmed in animal experiments and in human volunteers with normal perfusion, in whom the changes in alveolar ventilation and arterial PCO 2 resulted in parallel changes of the tonometric variables [27][28][29]. The significance of gastric tonometry, in detecting the failure of regional perfusion, was recognized later, when substantial differences were found between gastric and arterial PCO 2 in various clinical and experimental studies [30].…”

Section: The Correlation Between Gastric Mucosal Perfusion and Emptyimentioning

confidence: 66%

Recent Advances Of Mucosal Capnometry And The Perspectives Of Gastrointestinal Monitoring In The Critically Ill. A Pilot Study

Palágyi

Barna

Csábi

et al. 2016

The Journal of Critical Care Medicine

View full text Add to dashboard Cite

Mucosal capnometry involves the monitoring of partial pressure of carbon dioxide (PCO2) in mucous membranes. Different techniques have been developed and applied for this purpose, including sublingual or buccal sensors, or special gastrointestinal tonometric devices. The primary use of these procedures is to detect compensated shock in critically ill patients or patients undergoing major surgery. Compensatory mechanisms, in the early phases of shock, lead to the redistribution of blood flow towards the vital organs, within ostensibly typical macro-haemodynamic parameters. Unfortunately, this may result in microcirculatory disturbances, which can play a pivotal role in the development of organ failure. In such circumstances mucosal capnometry monitoring, at different gastrointestinal sites, can provide a sensitive method for the early diagnosis of shock. The special PCO2 monitoring methods assess the severity of ischaemia and help to define the necessary therapeutic interventions and testing of these monitors have justified their prognostic value. Gastrointestinal mucosal capnometry monitoring also helps in determining the severity of ischaemia and is a useful adjunctive in the diagnosis of occlusive splanchnic arterial diseases. The supplementary functional information increases the diagnostic accuracy of radiological techniques, assists in creating individualized treatment plans, and helps in follow-up the results of interventions. The results of a pilot study focusing on the interrelation of splanchnic perfusion and gastrointestinal function are given and discussed concerning recent advances in mucosal capnometry.

show abstract

“…Despite this concern, PCO 2 -gap remains the most reliable marker of tissue perfusion nowadays and should definitively replace pHi. 45,46 Further advances in the tonometric method were achieved by Salzman et al, 21 who reinvestigated the concept that PCO 2 measurements could be performed on gas aspirated from the stomach. The PCO 2 of this gas correlated with that measured on saline sampled from a conventional balloon tonometer, when perfusion was decreased by pericardial tamponade.…”

Section: The Tonometric Methodsmentioning

confidence: 99%

Gas tonometry for evaluation of gastrointestinal mucosal perfusion: experimental models of trauma, shock and complex surgical maneuvers - Part 1

Figueiredo

Silva

Cruz³

et al. 2002

Acta Cir. Bras.

View full text Add to dashboard Cite

Substantial clinical and animal evidences indicate that the mesenteric circulatory bed, particularly the gut mucosa, is highly vulnerable to reductions in oxygen supply and prone to early injury in the course of hemodynamic changes induced by trauma, shock, sepsis and several complex surgical maneuvers. Gut hypoxia or ischemia is one possible contributing factor to gastrointestinal tract barrier dysfunction that may be associated with the development of systemic inflammatory response and multiple organ dysfunction syndrome, a common cause of death after trauma, sepsis or major surgeries. Monitoring gut perfusion during experiments may provide valuable insights over new interventions and therapies highly needed to reduce trauma and sepsis-related morbidity and mortality. We present our experience with gas tonometry as a monitor of the adequacy of gastrointestinal mucosal perfusion in clinical and experimental models of trauma, shock and surgical maneuvers associated with abrupt hemodynamic changes, such as aortic occlusion and hepatic vascular exclusion. Next issue we will be presenting our experience with gas tonometry in experimental and clinical sepsis.

show abstract

Intraluminal “balloonless” air tonometry: A new method for determination of gastrointestinal mucosal carbon dioxide tension

Cited by 56 publications

References 0 publications

Influence of alveolar ventilation changes on calculated gastric intramucosal pH and gastric-arterial PCO2 difference

Influence of alveolar ventilation changes on calculated gastric intramucosal pH and gastric-arterial PCO2 difference

Recent Advances Of Mucosal Capnometry And The Perspectives Of Gastrointestinal Monitoring In The Critically Ill. A Pilot Study

Gas tonometry for evaluation of gastrointestinal mucosal perfusion: experimental models of trauma, shock and complex surgical maneuvers - Part 1

Contact Info

Product

Resources

About