Intramolecular monodealkylation during the attempted synthesis of diethylphosphonoacetohydroxamic acid

Chen, Ravit; Breuer, Eli

doi:10.1002/hc.10082

Cited by 7 publications

(1 citation statement)

References 17 publications

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“…The first stage involves the synthesis of trimethyl phosphonoacetate 2 by the previously developed facile and convenient РН-alkylation of dimethyl phosphite with methyl chloroacetate in the presence of potassium carbonate in the heterogeneous system "organic liquid phase-inorganic solid phase" [18] without using phase-transfer catalysts. The role of the latter is played to success by the starting and final phosphoryl-containing compounds [19][20][21].…”

Section: Synthesis Of the Compositionmentioning

confidence: 99%

Composition on the basis of phosphonoacetic acid. Synthesis and antiviral activity

Харламов

Бондаренко

et al. 2015

Russ J Gen Chem

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A manufacturable technology for the production of an antiviral composition containing phosphonoacetic acid, involing РН-alkylation of dimethyl phosphite with methyl chloroacetate under phasetransfer conditions and subsequent in situ hydrolysis of the intermediate product, was developed. The composition showed expressed antiviral effect against herpesviral infections caused by herpes simplex virus 1 and 2 and cytomegalovirus. The composition in the effective concentration range was found to exhibit no cytotoxic effect on VERO green monkey kidney and М-19 human diploid cell cultures. The resulting data suggest potential uses of the composition as an antiviral agent in practical medicine and as an antiviral additive to synthetic detergents for sanitation in health care and food production facilities.

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