Intramuscular arteether for treating severe malaria

Afolabi, Bosede B; Okoromah, Christy A. N.

doi:10.1002/14651858.cd004391.pub2

Cited by 16 publications

(11 citation statements)

References 16 publications

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“…In the first study, no statistically significant difference was found in the number of deaths or other outcomes, such as coma recovery time, parasite clearance time and fever clearance time. 13 However, in the second study the combined adverse outcome of either death or neurological sequelae was significantly less common in the artemether group. 12 After the meta-analysis mentioned above, new clinical trials in which artemether has been compared with quinine for the treatment of cerebral malaria in children have been carried out.…”

Section: Hmwe Hmwe Kyu a And Eduardo Fernández Amentioning

confidence: 86%

Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review

Kyu¹,

Fernández²

2009

Bull World Health Org

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Section: Hmwe Hmwe Kyu a And Eduardo Fernández Amentioning

confidence: 86%

Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review

Kyu¹,

Fernández²

2009

Bull World Health Org

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“…There is substantially less published information on artemotil than for artemether. Absorption is slower and more erratic, with some patients having undetectable plasma artemotil until more than 24 h after administration (Afolabi & Okoromah ; Li et al . ; Pareek et al .…”

Section: Pharmacology Of Antimalarial Drugsmentioning

confidence: 99%

Severe Malaria

2014

Tropical Med Int Health

465

354

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Fever and diarrhea developed in a 34-year-old Swiss man two weeks after his return from Madagascar. Before his visit he had not taken any prophylactic antimalarial drugs. Despite self-treatment with ciprofloxacin and metronidazole, he remained febrile. He also reported hematuria and dark urine. On admission, his temperature was 39.2°C and his vital signs and mental status were normal. The abdomen was tender, and the spleen was palpable 15 cm below the costal margin. The hemoglobin level was 12.4 g per deciliter, the hematocrit was 35 percent, the white-cell count was 8500 per cubic millimeter, and the platelet count was 15,000 per cubic millimeter. The creatinine level was 2.6 mg per deciliter (234 µmol per liter), the lactate dehydrogenase level was 1920 U per liter (normal, 187 to 443), and the bilirubin level was 11.5 mg per deciliter (197 µmol per liter); the results of other liver-function tests were in the normal range. Examination of blood smears showed severe infestation with Plasmodium falciparum, with 70 to 80 percent of red cells containing up to five parasites (small ring forms) per cell (long arrow in Panel A). Other features of P. falciparum that were present included chromatin dots (arrowheads in Panel A) and appliqué forms (short arrow in Panels A and B; Wright's stain, ¬1000). About 70 percent of the neutrophils contained hemozoin (shown in a band form [long arrows] in Panel B). The patient was treated with intravenous quinine sulfate and exchange transfusions, with dramatic improvement. The degree of parasitemia fell to 65 percent after the first exchange transfusion and to 8 percent after the second. The patient's course was complicated by acute renal failure, the acute respiratory distress syndrome, and spontaneous rupture of the spleen, necessitating continuous hemofiltration, mechanical ventilation, and laparotomy with splenectomy. Despite these complications , the patient was able to return home within three months and was well at the last follow-up visit.

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“…It may also be more effective than other artemisinin derivatives because of its oil solubility, longer half life, and increased chemical stability. 4 AE contains a stable endoperoxide bridge, this bridge is proposed to be responsible for its antimalarial activity. AE also possesses gametocytocidal properties through inhibiting parasite transmission.…”

Section: Introductionmentioning

confidence: 99%

Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of arteether: pharmacokinetics, toxicity and antimalarial activity in mice

et al. 2014

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Intramuscular arteether for treating severe malaria

Abstract: More trials with a larger number of participants are needed before a firm conclusion about the efficacy and safety of arteether can be reached.

Cited by 16 publications

References 16 publications

Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review

Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review

Severe Malaria

Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of arteether: pharmacokinetics, toxicity and antimalarial activity in mice

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