BACKGROUND: This case report describes the use of ultrasound-guided doxycycline injection as sclerotherapy for the treatment of aseptic olecranon bursitis. CASE REPORT: Our patient presented with a several-week history of posterior elbow swelling and tenderness. The clinical picture was consistent with aseptic olecranon bursitis. Ultrasonography was used to visualize posterior elbow structures and provide needle guidance to aspirate the fluid within the olecranon bursa and inject a sclerosant, doxycycline. The patient’s recovery was uneventful, and the bursitis did not recur. CONCLUSION: There are no other case reports describing ultrasound-guided injection of a sclerosant for treatment of aseptic olecranon bursitis. Doxycycline is an effective and safe sclerosant that can be considered for the treatment of aseptic olecranon bursitis. KEY WORDS: Olecranon bursitis, doxycycline, sclerotherapy, ultrasonography, injections, elbow