Intranasal midazolam: Sedation for radiological procedures

Abstract

Preoperative stress, anxiety and lack of cooperative ability of paediatric patients need sedation for radiological procedure. Aims: The purpose of study is to compare and evaluate efficiency and safety of two doses of intranasal midazolam. Settings and Design: This is a prospective Randomized controlled study of interventional type of study. Methods and Material: Sixty patient of age 1 to 4 years, ASA 1 and ASA2 undergoing radiological procedure were randomly divided into two groups. Group A received 0.3 mg/kg and Group B received 0.5 mg/kg of intranasal spray of midazolam. Sedation score, haemodynamic variations, ease of separation, Venepunture response and side effect were studied. Statistical analysis used: Data analysis was performed using SPSS for Windows, version 20.0(SPSS Inc., Chicago, IL) Results: Higher sedation score achieved earlier with 0.5mg/kg dose, Parenteral separation and IV line insertion was more easier with 0.5 mg/kg dose but recovery slight delay compare to 0.3 mg/kg dose after 20 min of procedure completion but there was no much prolongation of recovery time, at 30 min of all patient discharged in both groups. Conclusions: High Sedation score, parentral separation and response to IV line was earlier and easier with 0.5 mg/kg dose. Key Messages: Intranasal Midazolam is safe and effective as sedative in paediatric radiological procedure.