2007
DOI: 10.1159/000112312
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Intranasal Mupirocin Prophylaxis in Elective Surgery

Abstract: Background: Mupirocin is a natural antibiotic from Pseudomonas fluorescens which is available as a 2% ointment. The drug has been used mainly for topical treatment of the nasal vestibulum in patients carrying methicillin-resistant Staphylococcus aureus (MRSA). However, mupirocin is also active against methicillin-sensitive S. aureus. Nasal colonization with S. aureus has been identified as a significant risk factor for surgical site infection (SSI). Methods: Randomized trials and sequential cohort studies inve… Show more

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Cited by 46 publications
(27 citation statements)
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“…S.aureus is one of the most important pathogens in community and nosocomial, and its infection may lead to life-threatening disease (Peacock et al, 2001;Trautmann et al, 2008). The primary ecological niche for S.aureus in humans is the anterior nares.…”
Section: Introductionmentioning
confidence: 99%
“…S.aureus is one of the most important pathogens in community and nosocomial, and its infection may lead to life-threatening disease (Peacock et al, 2001;Trautmann et al, 2008). The primary ecological niche for S.aureus in humans is the anterior nares.…”
Section: Introductionmentioning
confidence: 99%
“…Na Alemanha, a eficácia de um programa que preconizava o isolamento e a terapia de descolonização de portadores de MRSA para a redução das infecções foi comprovada. Resultado semelhante foi também observado em UTI de hospitais canadenses (8)(9) .…”
Section: Introductionunclassified
“…Análise genética do mecanismo de resistência de mupirocina em isolados de Staphylococcus aureus mostrou a presença do gene mup A, detectado de um plasmídeo 38kb (8,14) .…”
Section: Introductionunclassified
“…Kontakt med MRSA-positive beboere Personale med individuelle risikofaktorer for baererskap 29 bør unngå å arbeide med MRSA-positive. Hvis det ikke kan unngås må nødvendige forholdsregler tas.…”
Section: Arbeidsrestriksjonerunclassified
“…Arbeidstakeren må vaere uten individuelle risikofaktorer for baererskap og det må vurderes hva slags arbeidsoppgaver vedkommende kan utføre og hvilke smitteverntiltak som er nødvendig. 29 Med individuelle risikofaktorer for baererskap menes her:…”
Section: Personale Med Mrsaunclassified