Intranasal volume increases with age: Computed tomography volumetric analysis in adults

Loftus, Patricia A.; Wise, Sarah K.; Nieto, D.; Panella, Nicholas J.; Aiken, Ashley H.; DelGaudio, John M.

doi:10.1002/lary.26064

Cited by 31 publications

(44 citation statements)

References 5 publications

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“…We found that increasing age was associated with a 0.2% increase in OC volume for each year of life in two independent samples, corresponding to an overall small effect size. This result is similar to age‐associated effects reported in previous studies of the entire intranasal space . In a CT study of 66 patients, Loftus et al found that for two cohorts with a mean age difference of 59.7 years, the older cohort's global intranasal volume was 11% larger in females and 20% larger in males .…”

Section: Discussionsupporting

confidence: 86%

“…The voxel‐based analyses demonstrated that these OC‐volume differences occurred in conjunction with modest volumetric expansion throughout much of the nasal cavity. The fact that only the Hammersmith sample had regions achieving statistical significance was not surprising given that the modest effects we observed were similar to those reported in studies of global intranasal volumes …”

Section: Discussionsupporting

confidence: 83%

“…One purported mechanism for the age‐associated increase in intranasal volumes is mucosal atrophy of the nasal and turbinate mucosa . To examine the association between age and nasal mucosa histology, Schrödter et al obtained biopsies of middle turbinate tissue from subjects aged 5 to 75 years.…”

Section: Discussionmentioning

confidence: 99%

“…Symptoms associated with presbynasalis include dryness, nasal obstruction, and olfactory dysfunction, which is observed in 50% of adults >60 years of age . In recent years, both computed tomography (CT) and acoustic rhinometry studies have identified global increases in intranasal volumes among older adults, which may contribute to this constellation of symptoms . Complaints of dryness and nasal obstruction may be related to alteration of intranasal heat and humidity exchange due to changing airflow patterns .…”

Section: Introductionmentioning

confidence: 99%

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Age‐related differences in olfactory cleft volume in adults: A computational volumetric study

et al. 2018

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Objectives/Hypothesis There is a growing need to understand the underlying mechanisms of age‐related olfactory dysfunction with the increasing proportion of older adults over the next 20 years. Despite the importance of olfactory cleft (OC) volumes on odorant deposition and olfactory function, little is known about age‐related changes to OC volume. The goal of this study was to use automated techniques in a cross‐sectional design to investigate the extent to which OC volumes vary with age and determine the spatial specificity of any age‐related effects. Study Design Retrospective cross‐sectional study. Methods Deformation‐based morphometry was utilized to measure OC and sinus volumes in two independent samples of 101 (Medical University of South Carolina [MUSC] sample) and 95 (Hammersmith sample) healthy adults who underwent T1‐weighted magnetic resonance imaging, with the Hammersmith sample serving as a replication sample. Results The mean age of the MUSC and Hammersmith samples were 54.9 ± 17.0 years and 52.1 years ± 15.7 years, respectively. In both samples, there was a significant positive association between age and OC volume that occurred at a constant rate across the lifespan (Cohen's f2 of 0.065 in the MUSC sample and 0.110 in the Hammersmith sample). Age‐associated OC volume increases occurred in conjunction with decreases in sinus volumes as well as increases in non‐OC nasal cavity volumes. Conclusions In this cross‐sectional study, there is an increase in OC volume with increasing age that occurs in the context of broad age‐associated differences in sinonasal anatomy. Future studies should investigate the impact of age‐associated differences in intranasal anatomy on nasal airflow, odorant deposition, and olfactory function. Level of Evidence 4 Laryngoscope, 129:E55–E60, 2019

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age‐related differences in olfactory cleft volume in adults: A computational volumetric study

et al. 2018

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“…Multivariate linear regression models were constructed to include age and tobacco use; these covariates were chosen as they may affect mucosal inflammation. 15, 16, 17, 18, 19 Associations between LM without OMC scores and TNSS and SNOT22 scores were evaluated in a similar fashion. Lastly, associations between individual sinus Chicago MLM scores and TNSS or SNOT22 scores were evaluated.…”

Section: Methodsmentioning

confidence: 99%

Three‐dimensional image analysis for staging chronic rhinosinusitis

Lim

Ramirez

Garneau

et al. 2017

Int Forum Allergy Rhinol

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Background Traditional methods of staging chronic rhinosinusitis (CRS) through imaging do not differentiate between degrees of partial mucosal sinus inflammation, thus limiting their utility as imaging biomarkers. We hypothesized that software-aided, quantitative measurement of sinus inflammation would generate a metric of disease burden that would correlate with clinical parameters in patients with suspected sinus disease. Methods Adults with rhinologic complaints undergoing CT imaging were recruited at an urban, academic, tertiary care center (n=45 with Lund-Mackay [LM] scores ≥ 4). 3D volumetric image analysis was performed using a semi-automated method to obtain a “Chicago-modified Lund-Mackay” (Chicago MLM) score, which provides a continuous scale to quantify extent of opacification. Linear regression was used to test the association of the Chicago MLM score with concurrent symptoms (total nasal symptom scores [TNSS]) and disease-specific quality of life (Sinonasal Outcome Test-22 [SNOT22]). Results Chicago MLM scores were significantly associated with both symptoms (p=0.037) and disease-specific quality of life (p=0.007). Inflammation in the ethmoid and sphenoid sinuses appeared to influence these associations. These findings were even more robust when analysis was limited to patients with more severe disease (LM>6). Conclusions The quantitative measurement of sinus inflammation by computer-aided 3D analysis correlates modestly with both symptoms and disease-specific quality of life. Posterior sinuses appear to have the greatest impact on these findings, potentially providing an anatomic target for clinicians to base therapy. The Chicago MLM score is a promising imaging biomarker for clinical and research use.

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International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

Wise

Lin

Toskala

et al. 2018

Int Forum Allergy Rhinol

339

453

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This critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.

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Intranasal volume increases with age: Computed tomography volumetric analysis in adults

Abstract: 4 Laryngoscope, 126:2212-2215, 2016.

Cited by 31 publications

References 5 publications

Age‐related differences in olfactory cleft volume in adults: A computational volumetric study

Age‐related differences in olfactory cleft volume in adults: A computational volumetric study

Three‐dimensional image analysis for staging chronic rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis

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