Intranodal benign thyroid tissue: Significance of HBME‐1 in differentiation from metastatic papillary thyroid carcinoma

Hirokawa, Mitsuyoshi; Horiguchi, Hironori; Wakatsuki, Soichi; Miki, Hitoshi; Sonoo, Hiroshi; Manabe, Toshiaki; Sendo, Toshiaki

doi:10.1034/j.1600-0463.2001.091211.x

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…All papillary carcinomas demonstrated positivity for HBME-1 in both the thyroid and lymph nodes, which corresponds to the observation of Torregossa et al [21] and Hirokawa et al [22]. Even more, in this study 82.4 % of primary tumours and their LNMs were highly HBME-1 positive.…”

Section: Discussionsupporting

confidence: 90%

“…Also, there is poor information about HBME-1 immunostaining in PTC metastases in lymph nodes. According to the occasional studies, all LNM of papillary carcinomas show strong HBME-1 positivity [21,22]. In addition, the few results concerning the association of HBME-1 expression with prognostic clinicopathological factors in thyroid carcinoma patients are controversial [9,23,24].…”

Section: Introductionmentioning

confidence: 99%

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Strong Expression of HBME-1 Associates with High-Risk Clinicopathological Factors of Papillary Thyroid Carcinoma

Denčić

Savin

Šelemetjev

et al. 2015

Pathol. Oncol. Res.

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Thyroid cancer comprises a heterogeneous group of lesions with great diversity of biological behaviour. Markers which could help clinicians to identify high-risk patients for tailored optimization of clinical management are of crucial importance. HBME-1 protein level was analysed immunohistochemically using routinely prepared archival tissue sections of a broad range of papillary thyroid carcinoma (PTC) variants and in corresponding lymph node metastases (LNM). The results were evaluated in comparison with clinicopathological features of PTC. Positive immunoreaction was noticed in most classical (83/92; 90.2 %), follicular (60/71; 84.5 %) and trabecular (4/5; 80.0 %) variants of PTC. All cases of macrofollicular, Warthin-like and diffuse sclerosing PTC variants were HBME-1 positive (4/4, 3/3, 2/2; 100 % respectively). Tall cell and solid PTC variants showed diversity of staining (2/3; 66.67 % and 13/23; 56.52 % respectively), while PTCs with mixed histological pattern containing insular areas were mainly weakly positive (2/5; 40.0 %). A single case of clear cell PTC variant showed no reaction. Moreover, all matched metastatic PTC into lymph nodes (LNM) were HBME-1 positive (17/17; 100 %) and expressed HBME-1 in a similar pattern to the matched primary tumour. We also found a statistically significant association between high HBME-1 expression and the presence of lymph node metastasis, advanced pT status and pTNM stage (P < 0.05), but only a tendency for association with extrathyroidal invasion of the tumour (P = 0.058). Therefore, we recommend using immunoexpression of HBME-1 as useful mean to increase the likelihood of detecting most PTC variants and to predict some unfavourable clinical parameters in these patients.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Strong Expression of HBME-1 Associates with High-Risk Clinicopathological Factors of Papillary Thyroid Carcinoma

Denčić

Savin

Šelemetjev

et al. 2015

Pathol. Oncol. Res.

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Ectopic thyroid tissue in the lateral lymph nodes: A rare case and literature review

Zhang,

Zheng,

Wang

et al. 2023

Preprint

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Background Ectopic thyroid tissue in the lateral lymph nodes is a rare phenomenon that is difficult to differentiate from metastatic thyroid carcinoma, which poses a great challenge to clinical decisions and may cause unnecessary operations. Puncture eluate thyroglobulin (FNA-Tg) of fine-needle aspiration is usually significantly elevated in malignant samples, but false-positive results still exist. Case Presentation We report a patient with lymph node ectopy who was suspected to have metastatic papillary thyroid cancer (PTC) preoperatively due to an undefined thyroid nodule and a drastically upregulated FNA-Tg level in the enlarged lymph nodes. In this review, we discuss the embryonic development of ectopic thyroid tissue in the lateral lymph nodes and the application of FNA-Tg in the diagnosis of nodal metastasis. We also present the individual treatment based on FNA and ultrasound evaluation. Conclusion For patients who have isolated suspicious lateral nodes but lack direct evidence of thyroid malignancy, ectopic thyroid tissue should be considered.

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Benign Intranodal Thyroid Tissue Similar to Nodal Metastasis of Thyroid Papillary Carcinoma: A Rare Case Report

Kang

Cha

2023

Diagnostics

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In patients with thyroid nodules, if the cervical lymph nodes gradually enlarge, a histological confirmation is required to rule out malignancy. Here is a case of benign intranodal thyroid tissue with cystic changes resembling lymph node metastasis of a papillary thyroid carcinoma. A 47-year-old man received ethanol sclerotherapy because of repeated enlargement of the thyroid gland 2 years prior to presentation. Subsequently, the patient underwent abscess removal from the deep neck and partial lobectomy of the attached left thyroid gland. Two months before the visit, extensive cervical lymphadenopathy was detected on ultrasonography (US) and computed tomography (CT). Total thyroidectomy and cervical lymph node dissection were performed to differentiate between metastatic papillary carcinoma of the thyroid gland and benign thyroid inclusions. Microscopic examination revealed multiple variable-sized nodules of benign thyroid follicles with cystic changes in both thyroid glands and bilateral cervical lymph nodes. An occult papillary microcarcinoma strongly positive for HBME-1 was also observed in the left thyroid lobe. However, the benign intranodal thyroid tissue was negative in both the real-time PCR-based BRAF V600E mutation test and HBME-1 immunohistochemical stain. Similarly, benign intranodal thyroid tissue can be enlarged by multiple cystic changes in a large number of lymph nodes along the neck node chain. For the differentiation of metastatic thyroid papillary carcinoma, real-time PCR-based BRAF V600E mutation test and HBME-1 immunohistochemical staining in addition to histological examination are helpful.

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Intranodal benign thyroid tissue: Significance of HBME‐1 in differentiation from metastatic papillary thyroid carcinoma

Cited by 3 publications

References 8 publications

Strong Expression of HBME-1 Associates with High-Risk Clinicopathological Factors of Papillary Thyroid Carcinoma

Strong Expression of HBME-1 Associates with High-Risk Clinicopathological Factors of Papillary Thyroid Carcinoma

Ectopic thyroid tissue in the lateral lymph nodes: A rare case and literature review

Benign Intranodal Thyroid Tissue Similar to Nodal Metastasis of Thyroid Papillary Carcinoma: A Rare Case Report

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