Intraocular pressure changes following the use of silicone oil or Densiron&amp;reg; 68 as endotamponade in pars plana vitrectomy

Romano, Mario R.; Angi, Martina; Romano, Vito; Parmeggiani, Francesco; Campa, Claudio; Valldeperas, Xavier; Costagliola, Ciro

doi:10.2147/opth.s14252

Cited by 18 publications

(21 citation statements)

References 27 publications

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“…Silicone oil (SO) is widely used in the treatment of complex vitreoretinal diseases. 1 2 However, a significant complication of intraocular SO is increased intraocular pressure (IOP). The etiopathogenesis of glaucoma after SO injection (SOI) is still not clear, and the real incidence varies in literature.…”

Section: Introductionmentioning

confidence: 99%

Trabeculectomy versus ex-press glaucoma filtration device in silicomacrophagocytic open angle glaucoma secondary to silicone oil emulsification

Errico¹,

Scrimieri²,

Riccardi³

et al. 2016

Middle East Afr J Ophthalmol

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Purpose:To compare the outcomes of Ex-PRESS device implantation versus trabeculectomy in patients with ocular hypertension after pars plana vitrectomy and silicone oil injection (SOI).Materials and Methods:Twenty-six consecutive eyes with ocular hypertension after pars plana vitrectomy and SOI were included in this study and randomized to one of two groups: A group treated with Ex-PRESS (model P50) placed under a scleral flap (Ex-PRESS group), and a group treated with trabeculectomy (trabeculectomy group). Complete success (intraocular pressure [IOP] <21 mmHg without medication) and qualified success rates (IOP <21 mmHg with one or two glaucoma medications) at 2 years postoperatively were analyzed. Between-groups comparison was performed with the Mann-Whitney U-test for continuous variables, and Fischer exact test for categorical data. Success rates between groups were compared using Kaplan-Meier life analysis and the log-rank test. P < 0.05 was considered statistically significant.Results:In the Ex-PRESS group, complete success was achieved in 73% eyes and qualified success in 81.8% of eyes. In the trabeculectomy group, complete success was achieved in 40% and qualified success was achieved in 60% of eyes. The difference in mean IOP between groups was statistically significant from the 3rd postoperative month onward (P = 0.007 at 3 months, P = 0.003 at 6 months, and P = 0.03 at 24 months).Conclusion:Ex-PRESS implantation was more effective than trabeculectomy in controlling IOP in ocular hypertensives after pars plana vitrectomy and SOI, but the surgical technique may require improvement.

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Section: Introductionmentioning

confidence: 99%

Trabeculectomy versus ex-press glaucoma filtration device in silicomacrophagocytic open angle glaucoma secondary to silicone oil emulsification

Errico¹,

Scrimieri²,

Riccardi³

et al. 2016

Middle East Afr J Ophthalmol

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“…stated that the long-term increased IOP depends on an open-angle mechanism rather than a closed-angle mechanism, since they did not report any case of pupillary block associated with SSO or HSO. [ 21 ] They stated that the persistence of a raised pressure could be related to the presence of emulsificated oil in the anterior chamber and in the trabecular meshwork, which persists after the removal of SO. [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 21 ] They stated that the persistence of a raised pressure could be related to the presence of emulsificated oil in the anterior chamber and in the trabecular meshwork, which persists after the removal of SO. [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 13 14 15 ] The OH represents an important risk factor for both SSO and HSO, which can lead to the development of secondary glaucoma. [ 16 17 ] To clarify, if this complication was associated to the type of SO, several studies have been conducted,[ 18 19 20 21 22 ] nevertheless they have reduced statistical power and discordant results. Therefore, a systematic review was needed to clarify this issue.…”

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confidence: 99%

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Development of ocular hypertension secondary to tamponade with light versus heavy silicone oil: A systematic review

Romano

Cruciani²,

Semeraro

et al. 2015

Indian J Ophthalmol

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Aim:The intraocular silicone oil (SO) tamponades used in the treatment of retinal detachment (RD) have been associated with a difference ocular hypertension (OH) rate. To clarify, if this complication was associated to use of standard SO (SSO) versus heavy SO (HSO), we performed a systematic review and meta-analysis of comparative study between two kind of SO (standard or light vs. heavy) for the treatment of RD and macular hole, without restriction to study design.Materials and Methods:The methodological quality of two randomized clinical trials (RCTs) were evaluated using the criteria given in the Cochrane Handbook for Systematic Reviews of Intervention, while three non-RCTs were assessed with the Newcastle-Ottawa Scale and Strengthening the Reporting of Observational Studies in Epidemiology checklists. We calculated Mantel-Haenszel risk ratio (RR) with 95% confidence intervals (95% CIs). The primary outcome was the rate of patients with OH treated with SSO compared to HSO.Results:There were a higher number of rates of OH in HSO compared to SSO. This difference was statistically significant with the fixed effect model (Mantel-Haenszel RR; 1.55; 95% CI, 1.06–2.28; P = 0.02) while there was not significative difference with the random effect model (Mantel-Haenszel RR; 1.51; 95% CI, 0.98–2.33; P = 0.06).Conclusion:We noted a trend that points out a higher OH rate in HSO group compared to SSO, but this finding, due to the small size and variable design of studies, needs to be confirmed in well-designed and large size RCTs.

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“…The late formation of synechiae has been shown to be the most common cause of secondary glaucoma that occur in a 3-40% of patients who have undergone vitreoretinal surgery with silicone (5). The incidence ranges from 2.2-56% at six to eight months (5). The mechanisms resulting in a secondary glaucoma can be summarized in seven causes: pupillary block, silicone oil migration, clogging of the trabecular meshwork by oil droplets, inflammation and trabeculitis, synechiae, overfilling the vitreous cavity with silicone oil, and pre-existing angle pathology/glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Penetrating Ocular Trauma with Retained Intraocular Foreign Body: Management, Follow-up and Medico-Legal Evaluation

Sorrentino¹,

Marsella²,

Feola³

et al. 2015

West Indian Med J

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Intraocular pressure changes following the use of silicone oil or Densiron® 68 as endotamponade in pars plana vitrectomy

Cited by 18 publications

References 27 publications

Trabeculectomy versus ex-press glaucoma filtration device in silicomacrophagocytic open angle glaucoma secondary to silicone oil emulsification

Trabeculectomy versus ex-press glaucoma filtration device in silicomacrophagocytic open angle glaucoma secondary to silicone oil emulsification

Development of ocular hypertension secondary to tamponade with light versus heavy silicone oil: A systematic review

Penetrating Ocular Trauma with Retained Intraocular Foreign Body: Management, Follow-up and Medico-Legal Evaluation

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