2007
DOI: 10.1158/1078-0432.ccr-07-1058
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Intraoperative Avidination for Radionuclide Therapy: A Prospective New Development to Accelerate Radiotherapy in Breast Cancer

Abstract: Purpose: In a continuous effort to seek for anticancer treatments with minimal side effects, we aim at proving the feasibility of the Intraoperative Avidination for RadionuclideTherapy, a new procedure for partial breast irradiation. Experimental Design: To assess doses of 90

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Cited by 24 publications
(35 citation statements)
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“…This approach, already tested in breast cancer by our group, has been shown to be a safe procedure, delivering about 20 Gy to the tumor bed after a single i.v. injection of 3.7 GBq of 90 Y-biotin [32][33][34].…”
Section: Discussionmentioning
confidence: 99%
“…This approach, already tested in breast cancer by our group, has been shown to be a safe procedure, delivering about 20 Gy to the tumor bed after a single i.v. injection of 3.7 GBq of 90 Y-biotin [32][33][34].…”
Section: Discussionmentioning
confidence: 99%
“…One patient underwent breast reduction for cosmetic purposes after tumour removal. All patients received avidin administration in the surgical bed as previously described [15, 20]. Briefly, after the primary tumour excision, the surgeon injected native avidin diluted into 30 ml of saline solution into and around the tumour bed, by means of three syringes (10 ml each).…”
Section: Methodsmentioning
confidence: 99%
“…The starting dose of avidin (100 mg) was based on the results of previous studies [15, 20]. In the present study, the lower avidin dose (50 mg) and the higher avidin dose (150 mg) were also investigated in order to identify the optimal amount able to provide a 20 Gy dose to the tumour area, after a fixed activity of 90 Y-biotin (3.7 GBq).…”
Section: Methodsmentioning
confidence: 99%
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