Intraoperative handheld optical coherence tomography forward-viewing probe: physical performance and preliminary animal imaging

Sun, Cuiru; Lee, Kenneth K. C.; Vuong, Barry; Cusimano, Michael D.; Brukson, Alexander; Mauro, Antonio; Munce, Nigel R.; Courtney, Brian K.; Standish, Beau A.; Yang, Victor X. D.

doi:10.1364/boe.3.001404

Cited by 14 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Speckle/echo-tracking based ultrasound elastography has been successfully used in clinical applications by applying a slight pressure through the ultrasound probe. 33 Similarly, this DIC-based speckle tracking algorithm has the potential to be integrated with a forward-viewing OCT probe 34 to perform elastography. OCE experimental results in Fig.…”

Section: Discussionmentioning

confidence: 99%

Digital image correlation–based optical coherence elastography

et al. 2013

Self Cite

View full text Add to dashboard Cite

Abstract. Optical coherence elastography (OCE) provides deformation or material properties, mapping of soft tissue. We aim to develop a robust speckle tracking OCE technique with improved resolution and accuracy. A digital image correlation (DIC)-based OCE technique was developed by combining an advanced DIC algorithm with optical coherence tomography (OCT). System calibration and measurement error evaluation demonstrated that this DIC-based OCE technique had a resolution of ∼0.6 μm displacement and <0.5% strain measurement in the axial scan direction. The measured displacement ranged from 0.6 to 150 μm, obtained via phantom imaging. The capability of the DIC-based OCE technique, for differentiation of stiffness, was evaluated by imaging a candle gel phantom with an irregularly shaped stiff inclusion. OCE imaging of a chicken breast sample differentiated the fat, membrane, and muscle layers. Strain elastograms of an aneurysm sample showed heterogeneity of the tissue and clear contrast between the adventitia and media. These promising results demonstrated the capability of the DIC-based OCE for the characterization of the various components of the tissue sample. Further improvement of the system will be conducted to make this OCE technique a practical tool for measuring and differentiating material properties of soft tissue.

show abstract

Section: Discussionmentioning

confidence: 99%

Digital image correlation–based optical coherence elastography

et al. 2013

Self Cite

View full text Add to dashboard Cite

show abstract

“…Galvanometer scanners and an additional lens prior to the GRIN relay were used for optical scanning at the sample plane, resulting in a 0.44 mm lateral field of view, 13 µm lateral resolution, and a frame rate of 100 B-scans/second. Another needle OCT probe also designed for neurosurgical applications employed a bayonet form factor identical to that of other clinically-accepted neurosurgical probes [100]. Optical scanning was achieved by enclosing the fiber in a platinum coil located in between two wires inside of the lumen of the probe.…”

Section: Needle-based Intraoperative Oct Probesmentioning

confidence: 99%

“…Doppler OCT is another functional extension that probes the velocity of moving scatterers within blood vessels to quantify blood flow [172,173]. Doppler OCT processing was incorporated in several HHOCT intraoperative probes to measure blood flow dynamics during animal surgery [100] and during mock surgery using an anastomosis model [91] (Fig. 11(b)).…”

Section: Intraoperative Oct Adjunctsmentioning

confidence: 99%

Review of intraoperative optical coherence tomography: technology and applications [Invited]

Carrasco-Zevallos

Viehland

Keller

et al. 2017

Biomed. Opt. Express

140

View full text Add to dashboard Cite

During microsurgery, en face imaging of the surgical field through the operating microscope limits the surgeon's depth perception and visualization of instruments and subsurface anatomy. Surgical procedures outside microsurgery, such as breast tumor resections, may also benefit from visualization of the sub-surface tissue structures. The widespread clinical adoption of optical coherence tomography (OCT) in ophthalmology and its growing prominence in other fields, such as cancer imaging, has motivated the development of intraoperative OCT for real-time tomographic visualization of surgical interventions. This article reviews key technological developments in intraoperative OCT and their applications in human surgery. We focus on handheld OCT probes, microscope-integrated OCT systems, and OCT-guided laser treatment platforms designed for intraoperative use. Moreover, we discuss intraoperative OCT adjuncts and processing techniques currently under development to optimize the surgical feedback derivable from OCT data. Lastly, we survey salient clinical studies of intraoperative OCT for human surgery.

show abstract

“…81.1b, where a coreless silica spacer made of no-core fiber (NCF) and a graded-index (GRIN) fiber microlens have been fusion-spliced directly to the end of the delivery fiber, and a side-deflecting mirror has been realized by angle polishing the fiber tip. A number of promising applications are emerging, including cancer diagnosis [3,4], pulmonary imaging [5,6], imaging of the eye [7,8], and imaging of the brain [9,10]. The long-term vision of this rapidly evolving field is to create high-speed, handheld OCT needle scanners that allow clinicians to perform real-time in vivo imaging, as illustrated in Fig.…”

Section: Introductionmentioning

confidence: 99%