Intraoperative irradiation after surgery for locally recurrent rectal cancer

Hashiguchi, Yojiro; Sekine, Takeshi; Sakamoto, Hirohiko; Tanaka, Yoïchi; Kazumoto, Tomoko; Kato, Shingo; Sakura, Mizuyoshi; Fuse, Yoshiaki; Suda, Yasuo

doi:10.1007/bf02237096

Cited by 67 publications

(50 citation statements)

References 14 publications

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“…Radical (R0) resection of LR is associated with at least twice higher survival than in non-radical (R1/R2) resection and remains the treatment of choice [21,22]. The tumor-free resection margin is a favorable prognostic factor for improved local control and overall survival [19][20][21][23][24][25][26]. In our study the survival time of patients after R0 resection was longer in comparison to non-radical resection group.…”

Section: Discussionmentioning

confidence: 57%

“…A significant increase in long term survival of patients with recurrent CRC after IORT has been reported [17,19,20]. Radical (R0) resection of LR is associated with at least twice higher survival than in non-radical (R1/R2) resection and remains the treatment of choice [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…The most common types of early postoperative complications are those associated with wound healing 3-46% and pelvic abscesses, intestinal obstructions and fistulas [17,20,22,29,32,37]. Postoperative complications vary from 15% to 68% [38].…”

Section: Discussionmentioning

confidence: 99%

“…Postoperative complications vary from 15% to 68% [38]. The percentage of serious postoperative complications ranges from 27% to 81% [20,21,28,35]. The most common complication after IO(E)RT is small bowel obstruction (14%) and pelvic abscesses (12%) [17,20].…”

Section: Discussionmentioning

confidence: 99%

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240. Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: A single centre retrospective study

Skórzewska

Jankiewicz

Mielko

et al. 2014

European Journal of Surgical Oncology (EJSO)

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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240. Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: A single centre retrospective study

Skórzewska

Jankiewicz

Mielko

et al. 2014

European Journal of Surgical Oncology (EJSO)

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“…Thirteen studies 3,6,7,11,15,19,25,28,35,36,47,52,57 specified the total dose of IORT, which mostly ranged from 10 to 20 Gy.…”

Section: Researchmentioning

confidence: 99%

Intentionally curative treatment of locally recurrent rectal cancer: a systematic review

Tanis

Doeksen

Lanschot

2013

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Intentionally curative treatment of locally recurrent rectal cancer: a systematic reviewBackground: There is a lack of outcome data beyond local recurrence rates after primary treatment in rectal cancer, despite more information being necessary for clinical decision-making. We sought to determine patient selection, therapeutic modalities and outcomes of locally recurrent rectal cancer treated with curative intent. Methods:We searched MEDLINE (1990-2010) using the medical subject headings "rectal neoplasms" and "neoplasm recurrence, local." Selection of cohort studies was based on the primary intention of treatment and availability of at least 1 outcome variable. Results:We included 55 cohort studies comprising 3767 patients; 8 studies provided data on the rate of intentionally curative treatment from an unselected consecutive cohort of patients (481 of 1188 patients; 40%). Patients were symptomatic with pain in 50% (796 of 1607) of cases. Overall, 3088 of 3767 patients underwent resection. The R0 resection rate was 56% (1484 of 2637 patients). The rate of external beam radiotherapy was 100% in 9 studies, 0% in 5 studies, and ranged from 12% to 97% in 37 studies. Overall postoperative mortality was 2.2% (57 of 2515 patients). Five-year survival was at least 25%, with an upper limit of 41% in 11 of 18 studies including at least 50 resections. We found a significant increase in reported survival rates over time (r 2 = 0.214, p = 0.007). Conclusion:More uniformity in treatment protocols and reporting on outcomes for locally recurrent rectal cancer is warranted. The observed improvement of reported survival rates in time is probably related to better patient selection and optimized multimodality treatment in specialized centres.

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Outcome of surgical resection of second-time locally recurrent rectal cancer

Harji

Sagar

Boyle

et al. 2013

Journal of British Surgery

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Intraoperative irradiation after surgery for locally recurrent rectal cancer

Abstract: The trends seen in resection with intraoperative electron beam irradiation are encouraging with regard to improvements in survival as compared with studies not using intraoperative electron beam irradiation treatment.

Cited by 67 publications

References 14 publications

240. Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: A single centre retrospective study

240. Intraoperative radiotherapy with low energy photons in recurrent colorectal cancer: A single centre retrospective study

Intentionally curative treatment of locally recurrent rectal cancer: a systematic review

Outcome of surgical resection of second-time locally recurrent rectal cancer

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