Intraoperative mitomycin C and cryotherapy as adjunct therapy for recurrent lobular capillary haemangioma of conjunctiva

Abstract

Recurrence of lobular capillary haemangioma of conjunctiva after surgical excision is rare but sometimes it may be difficult to manage multiple recurrences. A 31-year-old female patient presented with recurrent polypoid conjunctival lobular capillary haemangioma. Excisional biopsy was performed, followed by eye drop mitomycin C 0.04% four times a day for 1 week postoperatively. She reported again after 3 months with recurrence of vascular elongated nodular lesion. Excision of the mass with application of mitomycin C 0.02% intraoperatively for 1 min and cryotherapy using double thaw technique of the peripheral conjunctival margin was done. The histopathological examination confirmed the recurrence of lobular capillary haemangioma. On review, 1 year after treatment there was no evidence of recurrence. A combined use of cryotherapy and intraoperative mitomycin C as adjunctive therapy after surgical excision can successfully prevent further recurrence without any adverse effect.

Successful management of tracheal lobular capillary hemangioma with arterial embolization followed by electrosurgical snaring via flexible bronchoscopy in an 11-year-old boy: A case report and literature review

“…For instance, without scheduling BAE before surgery, Dabó et al described significant hemorrhage during tracheal LCH removal by rigid forceps via rigid bronchoscopy, and the instillation of cold saline and epinephrine failed to control the massive bleeding was described [20]. Inversely, in another case of BAE followed by lumpectomy under bronchoscopy, the amount of intraoperative blood loss was dramatically decreased [17]. This evidence further emphasizes that BAE was the procedure of choice in order to achieve better control of bleeding.…”

“…Despite their benign nature, localized recurrence is common, and thus, surgical debulking or excision remains the mainstay of treatment if symptomatic ( 6 , 12 – 14 ). Although there are a few studies of LCH on mucous membranes ( 2 , 3 , 6 , 11 , 15 – 17 ), tracheal origin for LCH is extremely rare among all primary tracheal tumors, with only four cases of children reported in the literature ( 9 , 10 , 18 , 19 ). Thus, there is limited knowledge about the presentation, behavior, and management of tracheal LCH, which represents a diagnostic and therapeutic challenge in pediatric patients.…”

Conservative Management of Giant Pyogenic Granuloma Post Strabismus Surgery: A Case Report and Literature Review

“…Accordingly, careful postoperative assessment is also essential [ 17 , 18 ]. The combination of cryotherapy and intraoperative mitomycin C may aid in preventing recurrence after surgical excision [ 20 ].…”