Intraoperative photodynamic therapy in complex treatment of malignant gliomas

Rynda, A. Yu.; Olyushin, V. E.; Ростовцев, Д. М.; Zabrodskaya, Yu. M.; Ulitin, А. Yu.; Papayan, G. V.

doi:10.17116/neiro20238701125

Cited by 9 publications

(1 citation statement)

References 19 publications

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“…In the case of brain tumors, one of the newest therapies is intraoperative photodynamic therapy [ 36 ].…”

Section: A Review Of the Literaturementioning

confidence: 99%

Photosensitizers for Photodynamic Therapy of Brain Cancers—A Review

Bartusik-Aebisher,

Woźnicki,

Dynarowicz

et al. 2023

Brain Sciences

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On average, there are about 300,000 new cases of brain cancer each year. Studies have shown that brain and central nervous system tumors are among the top ten causes of death. Due to the extent of this problem and the percentage of patients suffering from brain tumors, innovative therapeutic treatment methods are constantly being sought. One such innovative therapeutic method is photodynamic therapy (PDT). Photodynamic therapy is an alternative and unique technique widely used in dermatology and other fields of medicine for the treatment of oncological and nononcological lesions. Photodynamic therapy consists of the destruction of cancer cells and inducing inflammatory changes by using laser light of a specific wavelength in combination with the application of a photosensitizer. The most commonly used photosensitizers include 5-aminolevulinic acid for the enzymatic generation of protoporphyrin IX, Temoporfin—THPC, Photofrin, Hypericin and Talaporfin. This paper reviews the photosensitizers commonly used in photodynamic therapy for brain tumors. An overview of all three generations of photosensitizers is presented. Along with an indication of the limitations of the treatment of brain tumors, intraoperative photodynamic therapy and its possibilities are described as an alternative therapeutic method.

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“…In the case of brain tumors, one of the newest therapies is intraoperative photodynamic therapy [ 36 ].…”

Section: A Review Of the Literaturementioning

confidence: 99%