Intraoperative radiation therapy

Meiriño, R.; Orecchia, Roberto

doi:10.1016/j.critrevonc.2006.04.004

Cited by 43 publications

(18 citation statements)

References 100 publications

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“…Patients who in the past may not have been candidates for surgery may benefit from radical surgical resection combined with HDR-IORT. Patients whose recurrences extend to the pelvic sidewalls, and are thus not eligible for exenterations, should be referred to centers where HDR-IORT is available [57,58].…”

Section: Radiation Therapy For Recurrent Diseasementioning

confidence: 99%

Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma

Rodriguez

Ryu

et al. 2008

Oncol Rev

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Cervical cancer is one of the most common cancers affecting women, with most early disease treated with either surgery or radiation alone with an 85%-95% 5-year survival rate, while locally advanced cervical cancer (LACCA) requires multiple therapeutic modalities. The clear distinction between early and LACCA has, in recent years, blurred as stages IB2 and bulky IIA, which were traditionally thought of as early disease, have been shown to require more treatment than other early stage cervical cancer. LACC is now treated with cisplatin-based chemoradiation therapy based upon the results of the randomized co-operative group studies that demonstrated reduced relative risk of death, local failure rates, and incidence of distant metastases. Recurrent cervical cancer is devastating and is rarely cured. Treatment of recurrent cervical carcinoma depends on the previous therapy, the site of recurrence, and the extent of the recurrence. This review will outline the treatment options for the various stages of cervical cancer.

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Section: Radiation Therapy For Recurrent Diseasementioning

confidence: 99%

Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma

Rodriguez

Ryu

et al. 2008

Oncol Rev

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“…Several studies have demonstrated improved local control, especially in margin-negative patients [1, 7–9]. While external beam radiation therapy (EBRT) is the standard modality utilized to treat locally advanced or recurrent solid tumors, there are additional benefits associated with IORT.…”

Section: Purposementioning

confidence: 99%

“…A major advantage of HDR-IORT over IOERT and IORT using low-energy photons lies in its delivery method. HDR-IORT uses flexible and personalized applicators (Harrison-Anderson-Mick [HAM] applicator or Freiburg Flap) to deliver RT in contrast to the more rigid cone applicators used with both IOERT and IORT with low-energy photons [8, 9]. The flexible Freiburg applicator used in HDR-IORT is a silicone flap that can be re-shaped to accurately resemble the shape of the tumor bed [12].…”

Section: Purposementioning

confidence: 99%

High-dose-rate intraoperative radiation therapy: the nuts and bolts of starting a program

Moningi

Armour

Terezakis

et al. 2014

jcb

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High-dose-rate intraoperative radiation therapy (HDR-IORT) has historically provided effective local control (LC) for patients with unresectable and recurrent tumors. However, IORT is limited to only a few specialized institutions and it can be difficult to initiate an HDR-IORT program. Herein, we provide a brief overview on how to initiate and implement an HDR-IORT program for a selected group of patients with gastrointestinal and pelvic solid tumors using a multidisciplinary approach. Proper administration of HDR-IORT requires institutional support and a joint effort among physics staff, oncologists, surgeons, anesthesiologists, and nurses. In order to determine the true efficacy of IORT for various malignancies, collaboration among institutions with established IORT programs is needed.

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“…After salvage surgery, however, the subsequent local failure remains high with more than 50% of a new LR [10][11][12][13]. This low rate of curative salvage surgical resections has led to the investigation of different adjuvant treatments including intraoperative electron beam radiation therapy (IOERT) [14,15].…”

mentioning

confidence: 99%

Salvage surgery and radiotherapy including intraoperative electron radiotherapy in isolated locally recurrent tumors: Predictors of outcome

Cambeiro

Aristu

Moreno-Jiménez

et al. 2015

Radiotherapy and Oncology

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Intraoperative radiation therapy

Cited by 43 publications

References 100 publications

Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma

Current management of stage IB2 and bulky IIA, locally advanced, and recurrent cervical carcinoma

High-dose-rate intraoperative radiation therapy: the nuts and bolts of starting a program

Salvage surgery and radiotherapy including intraoperative electron radiotherapy in isolated locally recurrent tumors: Predictors of outcome

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