Intraperitoneal curcumin and vitamin E combination for the treatment of cisplatin-induced ototoxicity in rats

Investigation of the effects of curcumin, vitamin E and their combination in cisplatin-induced testicular apoptosis using immunohistochemical technique

“…the control group) through intraperitoneal route as indicated in the literature. [14,21] At the same day each treatment group received curcumin, vitamin E, and their combinations in that order. Curcumin was administered through intraperitoneal route at a dose of 200 mg/kg for 5 days at the same time of the day.…”

“…Available evidence demonstrate that increases in ROS production, and expression of endogenous antioxidant molecules support cisplatin toxicity. [11][12][13][14] As a result of OS, priorly, apoptotic cell loss occurs. [15] Cisplatin may produce reactive oxygen species, and inhibit antioxidant enzymes in normal tissues.…”

“…Curcumin has not any known toxic effect. [14,17,18] Vitamin E is an alpha-tocopherol with the highest antioxidant activity. Alpha-tocopherol is a membrane-specific antioxidant because of its lipophilic activity, and it is situated in the membrane-rich cell components.…”

“…Cisplatin chemotherapy cycles are related to decreases in the circulatory levels of vitamins C, and E, ceruloplasmin, and uric acid. [14,20] Therefore in this study, curcumin, vitamin E, and combination of both were administered to rats as an antioxidant support.…”

Inhibition by Egb761 of the effect of cellphone radiation on the male reproductive system

“…It was postulated that natural antioxidant molecule therapy attenuates oxidative stress-induced cell damage (18)(19)(20)(21) . EGb761, a standardized extract of Ginkgo biloba leaves, has antioxidant properties as a free-radical scavenger (22).…”