Intraperitoneal tonometry for detection of regional enteric ischaemia

Abstract

The care and handling of the animals was in accordance with legislation by the Swedish Board of Agriculture.

Detection of ischemia by Pco2 before adenosine triphosphate declines in skeletal muscle

“…This value is similar to what we found in kidney tissue (3) and to that measured in sublingual tissue (16). It is lower than what was found in the intestine (2) but higher than measured intraperitoneally using simple tonometry catheters (20) or a fiberoptic PCO 2 sensor (15) and gastrointestinal luminal tonometry (21,22). Despite the somewhat different values, which we suspect are partly due to different measurement technologies, all studies show a tissue-arterial blood gradient even under normal aerobic conditions.…”

Membrane microdialysis: Evaluation of a new method to assess splanchnic tissue metabolism*

“…The same is true for local tissue PCO 2 measured by tonometry (13). Because we induced moderate reduction of all abdominal flows, the location of the catheter is probably not so important.…”

“…12 (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) 21 .005 Portal d(v-a)Pco 2 (torr) 11 (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) 19 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) .005 Arterial plasma lactate concentration (mmol/L) 0.9 (0. Hence, as with many other clinically used variables, the trend (or response to treatment) is probably more important than the absolute value.…”

“…However, the clinical utility of gastrointestinal tonometry remains controversial (7)(8)(9)(10)(11). To avoid problems in the interpretation of tonometry-derived PCO 2 values-e.g., when CO 2 is produced in the stomach-intraperitoneal tonometry has been advocated to detect splanchnic malperfusion (12,13). Measurement of gut luminal lactate by microdialysis can be used to assess the adequacy of gut mucosal perfusion (14).…”

Sigmoid colonic reflectance pulse oximetry and tonometry in a porcine experimental hypoperfusion shock model

“…They investigated colonic oxygen saturation transanally in a porcine shock model, and the results seemed to be promising. Our own research group has been validating enteric pHi which had some limitations (16, 17). Therefore, we decided to validate the two competing methods against each other.…”