Intraplantar injection of bergamot essential oil induces peripheral antinociception mediated by opioid mechanism

Sakurada, Tsukasa; Mizoguchi, Hirokazu; Kuwahata, Hikari; Katsuyama, Soh; Komatsu, Toshimitsu; Morrone, Luigi Antonio; Corasaniti, Maria Tiziana; Bagetta, Giacinto; Sakurada, Shinobu

doi:10.1016/j.pbb.2010.09.020

Cited by 79 publications

(75 citation statements)

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“…It has also been shown that the antinociceptive effects of linalool are antagonized by either direct injection of naloxone hydrochloride into the hindpaw or i.p. administration of naloxone methiodide, an antagonist acting at the peripheral opioid receptors (28). The present data suggest that intraplantar injection of linalool significantly reduces paclitaxel-induced mechanical allodynia and hyperalgesia.…”

Section: Discussionsupporting

confidence: 52%

“…Linalool was diluted in jojoba wax (Simmondsia chinensis) (K.S.A. International, Co. Ltd., Kanagawa, Japan) to give a total amount of 2.5-10 μg/paw (28). Jojoba wax alone did not affect paclitaxel-induced mechanical allodynia or hyperal-hyperalgesia.…”

Section: Methodsmentioning

confidence: 99%

“…As previously reported (2,3,(22)(23)(24), (−) linalool administration produces antiinflammatory and antinociceptive activities in several behavioral assays. We recently reported that subcutaneous (s.c.) injection of capsaicin into the hindpaw produced a short-lasting paw-licking/biting response, which was dose-dependently inhibited by intraplantarly administered linalool (28). However, the antinociceptive efficacy of intraplantar linalool on paclitaxel-induced mechanical allodynia and hyperalgesia is unknown.…”

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Intraplantar injection of linalool reduces paclitaxel-induced acute pain in mice

et al. 2012

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Linalool is the principal component of many essential oils known to possess biological activities. We previously reported that intraplantar injection of linalool reduces the nociceptive response as assayed by the capsaicin test. In this study, we sought to determine whether intraplantar injection of linalool could influence the induction of acute pain (allodynia and hyperalgesia) by paclitaxel in mice. Paclitaxel is widely used in cancer chemotherapy for the treatment of solid tumors, but it sometimes induces moderate to severe acute pain. Paclitaxel administered intraperitoneally as a single dose of 5, 10 or 20 mg/kg produced mechanical allodynia and hyperalgesia in mice. Paclitaxel-induced mechanical allodynia and hyperalgesia began 1 day after administration of paclitaxel and resolved within 7 days. Linalool injected into the hindpaw caused a significant reduction in paclitaxel-induced mechanical allodynia and hyperalgesia. Pretreatment with naloxone hydrochloride, an opioid receptor antagonist, or naloxone methiodide, a peripherally acting μ-opioid receptor-preferring antagonist, significantly reversed linalool-induced antiallodynia and antihyperalgesia. Our results provide evidence for the involvement of peripheral opioids in antiallodynia and antihyperalgesia induced by linalool. These results suggest that activation of peripheral opioid receptors may play an important role in reducing paclitaxel-induced mechanical allodynia and hyperalgesia.The major classes of antineoplastic agents-the vinca alkaloids, taxanes, bortezomib and platinum-derived compounds-are associated with the development of dose-limiting neuropathic pain (12, 32). Paclitaxel is a taxane chemotherapeutic commonly used for the treatment of solid tumors and ovarian and breast cancers. Paclitaxel acts as an antimitotic by stabilizing microtubules against disassembly, thus inhibiting the cell cycle in late mitosis and ultimately inducing apoptosis (30). Peripheral neuropathy sometimes occurs as a side-effect of chemotherapeutic treatment with paclitaxel and often manifests as bilateral pain in the extremities in a stocking and glove-type distribution (5). This pain can greatly reduce patients' quality of life and affect activities of daily living. Furthermore, paclitaxel therapy often results in acute pain (16,21). Acute pain begins 1-3 days after the commencement of treatment with paclitaxel, resolves within 7 days and affects mostly the large axial muscular and joint regions (15). Paclitaxel-induced acute pain following paclitaxel infusion has commonly been treated with nonsteroidal antiinflammatory drugs, acetaminophen and opioid pain medications (15). In addition, ShakuyakuKanzo-To (a Japanese herb) (11), corticosteroids (17), antihistamines (18), opioids (29) and amifostine (10) have been investigated for the prevention

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Section: Discussionsupporting

confidence: 52%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Intraplantar injection of linalool reduces paclitaxel-induced acute pain in mice

et al. 2012

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“…BEO and (±) linalool were injected plantar surface of the right hindpaw 10 min before local injection of formalin (23). The opioid receptor antagonists, naloxone hydrochloride and its quaternary form, naloxone methiodide, were preinjected intraperitoneally (i.p.)…”

Section: Formalin Testmentioning

confidence: 99%

“…BEO and linalool were diluted in jojoba wax (Simmondsia chinensis) (K.S.A. International Co. Ltd., Kanagawa, Japan) to reach total amounts of 1.25-10 μg (11,23). Jojoba wax alone had no effect on formalin-induced nociception.…”

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<b>Effect of plantar subcutaneous administration of bergamot essential oil and linalool on formalin-induced nociceptive behavior in </b><b>mice </b>

et al. 2015

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This study investigated the effect of bergamot essential oil (BEO) or linalool, a major volatile component of BEO, on the nociceptive response to formalin. Plantar subcutaneous injection of BEO or linalool into the ipsilateral hindpaw reduced both the first and late phases of the formalininduced licking and biting responses in mice. Plantar subcutaneous injection of BEO or linalool into the contralateral hindpaw did not yield an antinociceptive effect, suggesting that the antinociceptive effect of BEO or linalool in the formalin test occurred peripherally. Intraperitoneal and plantar subcutaneous injection pretreatment with naloxone hydrochloride, an opioid receptor antagonist, significantly attenuated both BEO-and linalool-induced antinociception. Pretreatment with naloxone methiodide, a peripherally acting opioid receptor antagonists, also significantly antagonized the antinociceptive effects of BEO and linalool. Our results provide evidence for the involvement of peripheral opioids in antinociception induced by BEO and linalool. These results suggest that activation of peripheral opioid receptors may play an important role in reducing formalin-induced nociception.The essential oil of bergamot (BEO; Citrus bergamia Risso) is one of the most commonly used essential oils and is familiar to most of the general public. BEO is obtained by cold pressing of the epicarp and part of the mesocarp of the fresh bergamot fruit. BEO consists of a volatile (93-96%) and a nonvolatile fraction (4-7%); the former contains monoterpene and sesquiterpene hydrocarbons and oxygenated derivatives such as linalool and linalyl acetate, while the latter fraction contains waxes, polymethoxylated flavones, coumarins, and psoralens such as bergamottin and bergapten (6,14). BEO has been reported to minimize symptoms of stress-induced anxiety and mild mood disorders, as well as cancer pain, however the mechanistic basis for its use in such applications awaits discovery (1). A previous in vitro study showed that BEO reduced neuronal damage caused by excitotoxic stimuli (5), and significantly increased the extracellular levels of the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in rat hippocampus (15). Linalool is a monoterpene compound and is the main volatile component of the essential oils of various plants, including BEO. It has previously been reported that linalool administration produced antibacterial, anticonvulsant, and anti-inflammatory effects, as well as showing antinociceptive activity in several behavioral assays (2)(3)(4)(16)(17)(18)(19)(20). Furthermore, linalool can significantly reduce both mor-

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Linalool: a review on a key odorant molecule with valuable biological properties

Aprotosoaie

Hăncianu

Costache

et al. 2014

Flavour & Fragrance J

260

178

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This paper reports on the occurrence, biosynthesis, metabolism, biological and toxicological profile, and assessment of the authenticity of linalool. The main biological properties of linalool – sedative, anxiolytic, analgesic, anticonvulsant, anti‐inflammatory, local anaesthetic – are discussed in terms of the molecule's chirality influence, the mechanisms of activity and type of study (in vitro, in vivo, clinical studies). Also, there is a discussion of the recent data on the skin sensitizing potential of linalool based on numerous scientific studies which have been performed in the last few years. Comments of the authenticity assessment of linalool are made considering the limitations imposed by the chemical structure, vegetal matrix or processing methods, but also from the perspective of the powerful and sophisticated analytical techniques available today (GC‐C‐IRMS, enantio‐MDGC coupled to GC‐C‐IRMS, SNIF‐NMR). Copyright © 2014 John Wiley & Sons, Ltd.

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Intraplantar injection of bergamot essential oil induces peripheral antinociception mediated by opioid mechanism

Cited by 79 publications

References 36 publications

Intraplantar injection of linalool reduces paclitaxel-induced acute pain in mice

Intraplantar injection of linalool reduces paclitaxel-induced acute pain in mice

<b>Effect of plantar subcutaneous administration of bergamot essential oil and linalool on formalin-induced nociceptive behavior in </b><b>mice </b>

Linalool: a review on a key odorant molecule with valuable biological properties

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