Intrasession Repeatability and Intersession Reproducibility of Macular Vessel Parameters on Optical Coherence Tomography Angiography in Glaucomatous and Non-Glaucomatous Eyes

Vorperian, Alexander; Khan, Nasir; Lee, Jae; Burkemper, Bruce; Zhou, Xiao Hua; Grisafe, Dominic Joseph; LeTran, Vivian; Chu, Zhongdi; Wong, Brandon; Xu, Benjamin; Song, Brian J.; Wang, Ke; Richter, Grace M.

doi:10.1080/02713683.2022.2061004

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…It would be useful to investigate the repeatability and reproducibility of our device and software in control subjects to determine whether a difference in OCTA parameter measurements in a given patient is clinically significant or within the accepted “noise” of the technology and the patient’s daily physiological variation. Studies have shown good intra-session repeatability and good inter-session reproducibility of OCTA vessel parameter measurements in healthy and glaucomatous eyes using commercial software for OCTA devices [ 43 , 44 , 45 , 46 ]. The inter-session coefficient of repeatability is the best measure for this assessment as it represents the estimated range in which the difference between two repeated measurements for a given eye falls 95% of the time [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…The inter-session coefficient of repeatability is the best measure for this assessment as it represents the estimated range in which the difference between two repeated measurements for a given eye falls 95% of the time [ 43 ]. Vorperian et al [ 46 ], using commercial software for macular VD parameters, reported the inter-session within-eye coefficient of repeatability of 1.349 (95% CI 1.173; 1.528) for non-glaucomatous eyes and 1.767 (95% CI 1.501; 2.029) for glaucomatous eyes. This means that the absolute difference between two measurements and between two sessions should not be greater than 1.349 for non-glaucomatous and 1.767 for glaucomatous eyes in 95% of cases [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…Vorperian et al [ 46 ], using commercial software for macular VD parameters, reported the inter-session within-eye coefficient of repeatability of 1.349 (95% CI 1.173; 1.528) for non-glaucomatous eyes and 1.767 (95% CI 1.501; 2.029) for glaucomatous eyes. This means that the absolute difference between two measurements and between two sessions should not be greater than 1.349 for non-glaucomatous and 1.767 for glaucomatous eyes in 95% of cases [ 46 ]. In addition, there may be other factors that can directly affect the retinal microcirculation, such as caffeine consumption [ 47 ], nicotine [ 48 ], or level of physical activity [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

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Retinal Ganglion Cell Function and Perfusion following Intraocular Pressure Reduction with Preservative-Free Latanoprost in Patients with Glaucoma and Ocular Hypertension

Daka,

Sustar Habjan,

Meglič

et al. 2024

JCM

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(1) Background: Given the global prevalence of glaucoma and the crucial role of intraocular pressure (IOP) reduction in the management of the disease, understanding the immediate effects on retinal structure and function is essential. (2) Methods: This study aimed to assess the effects of preservative-free latanoprost on morphological and functional parameters in treatment-naïve patients with ocular hypertension and open-angle glaucoma. (3) Results: This study showed a significant reduction in IOP by an average of 30.6% after treatment with preservative-free latanoprost. Despite the significant reduction in IOP, no statistically significant changes were observed in the electroretinogram (ERG) nor the optical coherence tomography/angiography (OCT/OCTA) parameters compared to baseline. An exploration of the correlation between IOP changes and various parameters revealed a significant association solely with the macular IPL/INL plexus vessel density (VD) measured with OCTA. (4) Conclusions: This finding suggests a possible association between IOP reduction and changes in the macular microcirculation and provides valuable insights into the differential effects of latanoprost. Acknowledging the study limitations, this study emphasizes the need for larger, longer-term investigations to comprehensively assess the sustained effects of preservative-free latanoprost on both IOP and retinal parameters. In addition, exploring systemic factors and conducting subgroup analyses could improve personalized approaches to glaucoma treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Retinal Ganglion Cell Function and Perfusion following Intraocular Pressure Reduction with Preservative-Free Latanoprost in Patients with Glaucoma and Ocular Hypertension

Daka,

Sustar Habjan,

Meglič

et al. 2024

JCM

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Optical coherence tomography angiography in glaucoma

Hong,

Tan,

Chua

2024

Clinical and Experimental Optometry

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Variability of scan quality and perfusion density in longitudinal optical coherence tomography angiography imaging

Smith,

Josey,

West

et al. 2023

Br J Ophthalmol

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Background/aimsOptical coherence tomography angiography (OCT-A) images are subject to variability, but the extent to which learning impacts OCT-A measurements is unknown. We determined whether there is a learning effect in glaucoma patients and healthy controls imaged with OCT-A.MethodsNinety-one open-angle glaucoma patients and 54 healthy controls were imaged every 4 months over a period of approximately 1 year in this longitudinal cohort study. We analysed 15°×15° scans, centred on the fovea, in one eye of each participant. Two-dimensional projection images for the superficial, intermediate and deep vascular plexuses were exported and binarised after which perfusion density was calculated. Linear mixed-effects models were used to investigate the association between perfusion density and follow-up time.ResultsThe mean (SD) age of glaucoma patients and healthy controls was 67.3 (8.1) years and 62.1 (9.0) years, respectively. There was a significant correlation between perfusion density and scan quality in both glaucoma patients (r=0.50 (95% CI 0.42 to 0.58); p<0.05) and healthy controls (r=0.41 (95% CI 0.29 to 0.52); p<0.05). An increase in perfusion density occurred over time and persisted, even after adjustment for scan quality (1.75% per year (95% CI 1.14 to 2.37), p<0.01).ConclusionsPerfusion density measurements are subject to increasing experience of either the operator or participant, or a combination of both. These findings have implications for the interpretation of longitudinal measurements with OCT-A.

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Intrasession Repeatability and Intersession Reproducibility of Macular Vessel Parameters on Optical Coherence Tomography Angiography in Glaucomatous and Non-Glaucomatous Eyes

Cited by 3 publications

References 35 publications

Retinal Ganglion Cell Function and Perfusion following Intraocular Pressure Reduction with Preservative-Free Latanoprost in Patients with Glaucoma and Ocular Hypertension

Retinal Ganglion Cell Function and Perfusion following Intraocular Pressure Reduction with Preservative-Free Latanoprost in Patients with Glaucoma and Ocular Hypertension

Optical coherence tomography angiography in glaucoma

Variability of scan quality and perfusion density in longitudinal optical coherence tomography angiography imaging

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