Intrasession repeatability and intersession reproducibility of peripapillary OCTA vessel parameters in non-glaucomatous and glaucomatous eyes

Lee, Jae; Grisafe, Dominic Joseph; Burkemper, Bruce; Chang, Brenda Ryuna; Zhou, Xiao Hua; Chu, Zhongdi; Fard, Ali; Durbin, Mary K; Wong, Brandon; Song, Brian J.; Xu, Benjamin; Wang, Ke; Richter, Grace M.

doi:10.1136/bjophthalmol-2020-317181

Cited by 26 publications

(25 citation statements)

References 39 publications

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“…The signal strength is well-known as an important factor when interpreting the OCTA parameters in normal individuals and patients with various retinal diseases. 35 , 36 This study showed that the signal strength was also associated significantly with macular VD in patients with T2DM and patients with T2DM with HTN. Because the OCTA parameters of the macular microvasculature are strongly influenced by the signal strength, physicians should be aware that the comparison of such parameters would be inaccurate if the signal strength is low or different between two tests when analyzing OCTA data for patients with T2DM.…”

Section: Discussionmentioning

confidence: 75%

Impacts of Systemic Hypertension on the Macular Microvasculature in Diabetic Patients Without Clinical Diabetic Retinopathy

Lee

Koo

Lee

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Purpose To identify the impact of hypertension (HTN) on macular microvasculature in type 2 diabetes (T2DM) patients without clinical diabetic retinopathy. Methods In this retrospective cross-sectional study, subjects were divided into three groups: controls (control group), patients with T2DM (DM group), and patients with both T2DM and HTN (DM + HTN group). The vessel length density (VD) was compared among the groups. Linear regression analyses were performed to identify factors associated with VD. Results The VD in the control, DM, and DM + HTN groups was 20.43 ± 1.16, 19.50 ± 1.45, and 18.19 ± 2.06 mm −1 , respectively ( P < 0.001). The best-corrected visual acuity (B = −9.30; P = 0.002), duration of T2DM (B = −0.04; P = 0.020), HTN (B = −0.51; P = 0.016), signal strength (B = 1.12; P < 0.001), and ganglion cell–inner plexiform layer thickness (B = 0.06; P < 0.001) were significant factors affecting VD in patients with T2DM. Additionally, the hemoglobin A1c (HbA1c) (B = −0.49; P = 0.016) was significantly associated with VD in patients with both T2DM and HTN. Conclusions Patients with T2DM had impaired macular microvasculature, and patients with T2DM with HTN exhibited greater impairment of the microvasculature than did patients with T2DM only. Additionally, physicians should be aware that the macular microvasculature would be more vulnerable to hyperglycemic damage under ischemic conditions by HTN.

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Section: Discussionmentioning

confidence: 75%

Impacts of Systemic Hypertension on the Macular Microvasculature in Diabetic Patients Without Clinical Diabetic Retinopathy

Lee

Koo

Lee

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…The mean SS (B = − 2.028; p < 0.001) affected long-term repeatability. Previous studies have also identified the SS as an important factor in OCTA evaluations 11 , 14 , 20 – 23 . Fenner et al 20 reported that motion artifacts and TopQ scores (similar to the SS) could be used to evaluate the quality and reliability of OCTA images.…”

Section: Discussionmentioning

confidence: 95%

“…The sample sizes in these studies were small, and the analyses were limited to calculating the CV. Lee et al 14 reported good long term reproducibility of peripapillary OCTA measurements in 120 individuals with suspicion of glaucoma, using a clinic-oriented quantification software (Cirrus) (CV 2.02% and ICC 0.852 for PD). Although this study did not include healthy eyes, the results are similar to ours.…”

Section: Discussionmentioning

confidence: 99%

“…In long-term repeatability, previous our study found that macula OCTA had reasonable repeatability in healthy eyes 13 . Furthermore, Lee et al 14 reported good long-term reproducibility of peripapillary OCTA measurements in patients with suspicion of glaucoma. However, the long-term repeatability of peripapillary OCTA measurements in healthy eyes has not been studied.…”

Section: Introductionmentioning

confidence: 99%

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Long-term repeatability of peripapillary optical coherence tomography angiography measurements in healthy eyes

Lee

Kim

et al. 2021

Sci Rep

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This is a prospective observational study to establish the short- and long-term repeatability of measurements of peripapillary optical coherence tomography angiography (OCTA) parameters in healthy eyes and identify factors affecting long-term repeatability. We enrolled 84 healthy eyes. Participants with a history of any ophthalmic disease (except high myopia) or intraocular surgery were excluded from the study. An experienced examiner performed OCTA using disc-centered 6 × 6 mm scans. All examinations were conducted twice at 5-min intervals at the initial visit and repeated at least 6 months later. For short-term repeatability, the coefficient of variation (CV) was 2.94–4.22% and the intraclass correlation coefficient (ICC) was 0.840–0.934. For long-term repeatability, the CV was 2.73–3.84% and the ICC was 0.737–0.934. Multivariate analyses showed that the axial length (AL) (B = 0.970; p = 0.002) and mean signal strength (SS) (B = − 2.028; p < 0.001) significantly affected long-term repeatability. Measurements of peripapillary OCTA parameters exhibited excellent short-term and good long-term repeatability in healthy individuals. The mean SS and AL affected long-term repeatability and should be considered while interpreting peripapillary OCTA images.

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“…Peripapillary OCTA vessel parameters have greater intrasession repeatability than intersession reproducibility in both non-glaucomatous and glaucomatous eyes (7). Previous studies have compared the flow pattern using OCTA in the peripapillary region in normal eyes, glaucomatous eyes, and acute nonarteritic anterior ischemic optic neuropathy (NAION) eyes.…”

Section: Dear Editorsmentioning

confidence: 99%

Optic nerve head injury and optical coherence tomography angiography

Ma¹,

Hua²

2021

Quant Imaging Med Surg

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Intrasession repeatability and intersession reproducibility of peripapillary OCTA vessel parameters in non-glaucomatous and glaucomatous eyes

Cited by 26 publications

References 39 publications

Impacts of Systemic Hypertension on the Macular Microvasculature in Diabetic Patients Without Clinical Diabetic Retinopathy

Impacts of Systemic Hypertension on the Macular Microvasculature in Diabetic Patients Without Clinical Diabetic Retinopathy

Long-term repeatability of peripapillary optical coherence tomography angiography measurements in healthy eyes

Optic nerve head injury and optical coherence tomography angiography

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