Intrathoracic Abnormalities Demonstrated by Technetium-99m Sulfur Colloid Imaging

Shih, Wei-Jen; Domstad, Peggy A.; Friedman, Bruce; DeLand, Frank H.

doi:10.1097/00003072-198611000-00016

Cited by 9 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PIM have been described in the species from the Laurasiatheria superorder whereas no PIM were observed in primates and mice, species belonging to the Euarchontoglires superorder 6 , 7 , 9 , 14 . However, in rats and humans, evidence exist of a few constitutive PIM that increase in number upon liver dysfunctions 35 – 37 . In the rat model, PIM induced upon bile-duct ligation were shown to be responsible for endotoxin-induced mortality 38 .…”

Section: Discussionmentioning

confidence: 99%

Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus

Bordet

Maisonnasse

Renson

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Lung inflammation is frequently involved in respiratory conditions and it is strongly controlled by mononuclear phagocytes (MNP). We previously studied porcine lung MNP and described a new population of cells presenting all the features of alveolar macrophages (AM) except for their parenchymal location, that we named AM-like cells. Herein we showed that AM-like cells are macrophages phagocytosing blood-borne particles, in agreement with a pulmonary intravascular macrophages (PIM) identity. PIM have been described microscopically long time ago in species from the Laurasiatheria superorder such as bovine, swine, cats or cetaceans. We observed that PIM were more inflammatory than AM upon infection with the porcine reproductive and respiratory syndrome virus (PRRSV), a major swine pathogen. Moreover, whereas PRRSV was thought to mainly target AM, we observed that PIM were a major producer of virus. The PIM infection was more correlated with viremia in vivo than AM infection. Finally like AM, PIM-expressed genes were characteristic of an embryonic monocyte-derived macrophage population, whose turnover is independent of bone marrow-derived hematopoietic precursors. This last observation raised the interesting possibility that AM and PIM originate from the same lung precursor.

show abstract

Section: Discussionmentioning

confidence: 99%

Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus

Bordet

Maisonnasse

Renson

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…17,19 More rarely, it has been noted during the rejection of liver allografts, 18 trauma, 47 infection 48 and various types of malignancies, including nonhepatic malignancy. [20][21][22][23] Pulmonary RES uptake has also been demonstrated in bacteremia, 24 including a direct demonstration of pulmonary clearance of bloodborne bacteria in a patient. 49 Often, the lung RES uptake disappears if the underlying disease resolves.…”

Section: Figure 4 Luciferase Expression 3 Days After Intravenous Injementioning

confidence: 99%

“…Since currently ongoing clinical trials with adenovirus vectors include patients with liver disease, it is important to note that there is extensive clinical evidence -using RES tracers such as 99m Tc-sulfur colloid -that pulmonary reticuloendothelial uptake can occur in patients with cirrhosis, mucopolysaccharidosis, hepatic allograft rejection, infection or malignancy. [16][17][18][19][20][21][22][23][24] Since the uptake of adenovirus vectors by macrophages can result in a great deal of inflammation, uptake of adenoviral vectors by PIMs in the lungs might raise the potential for unexpected pulmonary inflammation and pathology.…”

Section: Introductionmentioning

confidence: 99%

Unexpected pulmonary uptake of adenovirus vectors in animals with chronic liver disease

Tian

Müller

et al. 2004

Gene Ther

View full text Add to dashboard Cite

When adenovirus vectors are injected intravenously, most of the virions are quickly taken up by the reticuloendothelial system, primarily by the liver macrophages known as Kupffer cells. However, little is known about the behavior of adenovirus vectors when there is pre-existing liver disease. To study this, we examined the biodistribution of intravenously injected vector in a rat model of cirrhosis induced by bile duct ligation. Using quantitative PCR and fluorescently tagged adenovirus vectors, we observed a significant reduction in vector uptake by the cirrhotic liver and increased accumulation in the lungs. Immunocytochemistry and electron microscopy demonstrated that this was due to changes in the reticuloendothelial system, with the vector being taken up by large numbers of pulmonary intravascular macrophages in the lungs of cirrhotic rats. Interestingly, expression of vector-encoded luciferase was significantly reduced in the livers of cirrhotic rats, but was not increased in the lungs. These data demonstrate that the biodistribution of adenovirus vectors in rats is altered by cirrhosis, which suggests the possibility that these vectors might behave unexpectedly in patients with pre-existing liver conditions, particularly since pulmonary reticuloendothelial changes are known to occur in human disease.

show abstract

“…Although PIMs are not observed in healthy humans, there is evidence of their existence in patients with liver disorders. [199][200][201][202]…”

Section: Pulmonary Macrophages: Key Players In the Immune Defence Omentioning

confidence: 99%

“…This group also reported an increase in PIMs from foals that died from sepsis, compared to healthy animals. Although PIMs are not observed in healthy humans, there is evidence of their existence in patients with liver disorders 199‐202 …”

Section: The Mononuclear Phagocyte System Of the Horsementioning

confidence: 99%

The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity

Karagianni

Lisowski

Hume

et al. 2020

Equine Veterinary Journal

View full text Add to dashboard Cite

Horses are already recognised as models for several human diseases, including metabolic syndrome, asthma, musculoskeletal diseases, melanoma and autoimmune uveitis. 1-6 More than 100 equine hereditable conditions may serve as models for human disorders, including inflammation, muscular or fertility disorders, osteoarthritis and even depression. 7-10 The horse has the potential to represent an appropriate

show abstract

Intrathoracic Abnormalities Demonstrated by Technetium-99m Sulfur Colloid Imaging

Cited by 9 publications

References 0 publications

Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus

Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus

Unexpected pulmonary uptake of adenovirus vectors in animals with chronic liver disease

The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity

Contact Info

Product

Resources

About