Intratympanic dexamethasone plus melatonin versus melatonin only in the treatment of unilateral acute idiopathic tinnitus

Albu, Silviu; Chirteş, Felician

doi:10.1016/j.amjoto.2014.06.009

Cited by 12 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because most studies failed to report median values, we compared the mean values. Our average THI score was 28.34 in comparison to the range of 40–55 found in the literature (Kaldo et al, 2007; Westin et al, 2011; Albu and Chirtes, 2014; Jasper et al, 2014). The TFI average was 31.74 vs. 40.6 (Fackrell et al, 2016), so that the overall score was lower than that typically found in the literature.…”

Section: Discussionsupporting

confidence: 45%

“…The TFI average was 31.74 vs. 40.6 (Fackrell et al, 2016), so that the overall score was lower than that typically found in the literature. Similarly, the anxiety level of 5.12 measured with the HADS was lower than that reported in other studies (6.2–8.7; Kaldo et al, 2007; Westin et al, 2011; Albu and Chirtes, 2014; Jasper et al, 2014). The average of 3.44 for depression in the STOP cohort was also lower than the range of 4.05–6.5 described in the literature (Kaldo et al, 2007; Westin et al, 2011; Albu and Chirtes, 2014; Jasper et al, 2014).…”

Section: Discussionmentioning

confidence: 50%

“…Similarly, the anxiety level of 5.12 measured with the HADS was lower than that reported in other studies (6.2–8.7; Kaldo et al, 2007; Westin et al, 2011; Albu and Chirtes, 2014; Jasper et al, 2014). The average of 3.44 for depression in the STOP cohort was also lower than the range of 4.05–6.5 described in the literature (Kaldo et al, 2007; Westin et al, 2011; Albu and Chirtes, 2014; Jasper et al, 2014). The average values of 13.86 of tinnitus-specific cognitions measured with the TCS were almost two times less than the baseline score of 21.11 in the study by Cima et al (2012).…”

Section: Discussionmentioning

confidence: 50%

See 2 more Smart Citations

Validation of Online Versions of Tinnitus Questionnaires Translated into Swedish

Müller¹,

Edvall

Idrizbegovic

et al. 2016

Front. Aging Neurosci.

View full text Add to dashboard Cite

Background: Due to the lack of objective measures for assessing tinnitus, its clinical evaluation largely relies on the use of questionnaires and psychoacoustic tests. A global assessment of tinnitus burden would largely benefit from holistic approaches that not only incorporate measures of tinnitus but also take into account associated fears, emotional aspects (stress, anxiety, and depression), and quality of life. In Sweden, only a few instruments are available for assessing tinnitus, and the existing tools lack validation. Therefore, we translated a set of questionnaires into Swedish and evaluated their reliability and validity in a group of tinnitus subjects.Methods: We translated the English versions of the Tinnitus Functional Index (TFI), the Fear of Tinnitus Questionnaire (FTQ), the Tinnitus Catastrophizing Scale (TCS), the Perceived Stress Questionnaire (PSQ-30), and the Tinnitus Sample Case History Questionnaire (TSCHQ) into Swedish. These translations were delivered via the internet with the already existing Swedish versions of the Tinnitus Handicap Inventory (THI), the Hospital Anxiety and Depression Scale (HADS), the Hyperacusis Questionnaire (HQ), and the World Health Organization Quality of Life questionnaire (WHOQoL-BREF). Psychometric properties were evaluated by means of internal consistency [Cronbach's alpha (α)] and test–retest reliability across a 9-week interval [Intraclass Correlation Coefficient (ICC), Cohen's kappa] in order to establish construct as well as clinical validity using a sample of 260 subjects from a population-based cohort.Results: Internal consistency was acceptable for all questionnaires (α > 0.7) with the exception of the “social relationships” subscale of the WHOQoL-BREF. Test–retest reliability was generally acceptable (ICC > 0.70, Cohens kappa > 0.60) for the tinnitus-related questionnaires, except for the TFI “sense of control” subscale and 15 items of the TSCHQ. Spearmen rank correlations showed that almost all questionnaires on tinnitus are significantly related, indicating that these questionnaires measure different aspects of the same construct. The data supported good clinical validity of the tinnitus-related questionnaires.Conclusion: Our results suggest that most Swedish adaptations of the questionnaires are suitable for clinical and research settings and should facilitate the assessment of treatment outcomes using a more holistic approach by including measures of tinnitus fears, emotional burden, and quality of life.

show abstract

Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 50%

See 1 more Smart Citation

Validation of Online Versions of Tinnitus Questionnaires Translated into Swedish

Müller¹,

Edvall

Idrizbegovic

et al. 2016

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…As in a randomized clinical trial by Neri et al .,[ 3 ] it was found that however melatonin alone is efficient in treating tinnitus but they also demonstrated melatonin in conjunction with Sulodexide has better effects. In another study by Albu and Chirtes[ 16 ] that intratympanic dexamethasone plus melatonin is more efficient in treating tinnitus than melatonin alone. Furthermore, there has been also evidence indicating sertraline to be more effective than placebo in treating tinnitus.…”

Section: Discussionmentioning

confidence: 99%

Comparison of melatonin and sertraline therapies on tinnitus: A randomized clinical trial

et al. 2017

View full text Add to dashboard Cite

Background:Tinnitus is the perception of noise or ringing without external acoustic stimulants which affects almost 10% of general population. Many therapies have been recommended including diet modifications, herbal remedies, and chemical drugs. Most common utilized drugs for tinnitus are melatonin and antidepressants such as sertraline which have been proven in different studies. In this study, we aimed to compare the efficacy of melatonin and sertraline in treating tinnitus for the first time.Methods:In this clinical trial, 70 patients with tinnitus according to inclusion and exclusion criteria were included and randomly divided into two groups: melatonin group, taking melatonin 3 mg once daily and sertraline group taking sertraline 50 mg once daily, all treating for 3 months. Before and after treatments, every patient received Tinnitus Handicap Inventory (THI) questionnaire and severity of tinnitus was assessed, and data analysis was performed.Results:Before treatments, the mean of THI score for melatonin and sertraline groups were 45.02 ± 17.67 and 44.85 ± 20.57, respectively. There was no significant difference between both groups THI score (P = 0.23). After 3 months, the mean of THI scores for melatonin and sertraline groups were 30.29 ± 19.62 and 36.96 ± 25.03, respectively which the mean of THI scores in two groups was decreased significantly (P < 0.01, for-both). In addition, indicated the significant decline in THI score of melatonin group who were under treatments with melatonin 3 mg once daily (P = 0.02).Conclusions:Here in this clinical trial, we demonstrated that both melatonin and sertraline are efficient in treating tinnitus, but the usage of melatonin 3 mg once daily is more effective.

show abstract

“…The positive aspects of adding a steroid to therapy were confirmed by Albu and Chirtes, in their RCT. The addition of dexamethasone to melatonin therapy had a statistically significant effect on reducing tinnitus compared to melatonin alone [58]. Most articles on the subject conclude that intratympanic steroid injections are effective mostly in patients with acute tinnitus and mostly show no effect in those with chronic tinnitus [52,59].…”

Section: Corticosteroids In Tinnitusmentioning

confidence: 99%

Corticosteroids in Otorhinolaryngology

Skarżyńska¹,

Skarżyński²

2021

Corticosteroids - A Paradigmatic Drug Class

View full text Add to dashboard Cite

This paper aims to present the role of the therapy of corticosteroids in otorhinolaryngological diseases such as Meniere’s disease, partial deafness, sudden sensorineural hearing loss, and tinnitus. The effectiveness of treatment depends on many factors, for instance, the duration of the therapy, occurrence or not of adverse reactions, especially in those patients with additional risk factors as comorbidities. Additionally, the optimal way of administration has been widely discussed.

show abstract

Intratympanic dexamethasone plus melatonin versus melatonin only in the treatment of unilateral acute idiopathic tinnitus

Cited by 12 publications

References 19 publications

Validation of Online Versions of Tinnitus Questionnaires Translated into Swedish

Validation of Online Versions of Tinnitus Questionnaires Translated into Swedish

Comparison of melatonin and sertraline therapies on tinnitus: A randomized clinical trial

Corticosteroids in Otorhinolaryngology

Contact Info

Product

Resources

About