Intravaginal culture using INVOCELL: Is it a viable treatment option for infertility?

Babayev, Elnur; Jain, Tarun

doi:10.1016/j.xfre.2020.12.005

Cited by 1 publication

(2 citation statements)

References 5 publications

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“…Few studies compared the blastocyst formation rates between INVOcell and conventional IVF [29,30]. However, a recent study has reported that INVOcell results in a better blastocyst formation rate than cIVF [30][31][32]. This evidence is consistent with our findings.…”

Section: Discussionsupporting

confidence: 91%

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Comparison of Treatment Outcomes among Sibling Oocytes Using Different Culture Systems—Conventional IVF versus INVOcell Device—And Evaluation of INVOcell User Satisfaction: The INVOcIVF Study

Mohsin

Chue²,

Hamid³

et al. 2022

IJERPH

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INVOcell is considered an alternative to conventional IVF proposed for intravaginal embryo culture; however, implementation is still low because evidence is scanty regarding its outcome and, most importantly, the device’s user satisfaction. Thus, we aim to compare the embryo outcome of sibling oocytes following INVOcell culture with conventional IVF (cIVF) by assessing its clinical outcome (fertilization, blastulation rate, and good embryo quality) and the user satisfaction evaluation based on a local validation questionnaire. A prospective study was done at a university-setting hospital for 12 months (July 2021–2022). The oocytes collected were divided into INVOcell and cIVF groups equally. Inclusion criteria included <40 years old and body mass index (BMI) < 30 kg/m2. The pre- and post-satisfaction questionnaires were assessed. In total, 23 women were included following standard controlled ovarian stimulation (COS). The mean age was 32.9, and the mean BMI was 24.9 kg/m2. Most of them suffered from tubal factors. A total of 252 oocytes were collected and incubated accordingly (cIVF; 138, INVOcell; 114). The blastulation rate was superior in the INVOcell group (p = 0.16); otherwise, the fertilization rate and good embryo quality were not significantly different between both methods (p > 0.05). Overall, women were satisfied with the INVOcell device as they were adequately advised, follow-up was scheduled, and the lowest score was obtained for all side effects of the device. Although both methods produce similar fertilization rates and good-quality embryos, the blastulation rates were better in the INVOcell group. Functionally, it is a user-friendly device and tolerable. Therefore, INVOcell can be used as an alternative method for reproductive treatment in carefully selected patients without jeopardizing the IVF outcomes.

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Section: Discussionsupporting

confidence: 91%

“…Otherwise, INVOcell and conventional IVF show no difference in the producibility of good-quality embryos. Other studies had the same conclusion [3,8,22,30,31].…”

Section: Discussionmentioning

confidence: 56%