Intravenous Administration of Hyperoxygenated Solution Attenuates Pulmonary Edema Formation in Phosgene-Induced Acute Lung Injury in Rabbits

Wang, Ling; Liu, Chunran; Zhang, Hui; Gao, Changjun; Chai, Weidong; Xu, Ruifen; Wang, Huixia; Xu, Li

doi:10.1016/j.jss.2008.09.017

Cited by 10 publications

(4 citation statements)

References 19 publications

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“…to increase blood oxygen levels, reduce blood lactate levels, improve tissue hypoxia and damage. [25][26][27] Wang et al reported that intravenous administration of hyperoxygenated solution attenuates phosgene-induced ALI 28 and Xu et al demonstrated the therapeutic effect of hyperoxygenated solution on oleic acid induced ALI. 13 Thus, the positive effect of hyperoxygenated solution on ALI is relatively certain.…”

Section: Hydrogen-rich Saline Could Decrease Inflammatory Factors In ...mentioning

confidence: 99%

Hydrogen‐rich and hyperoxygenate saline inhibits lipopolysaccharide‐induced lung injury through mediating NF‐κB/NLRP3 signaling pathway in C57BL/6 mice

Fan

Wang

Feng

et al. 2022

Environmental Toxicology

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Background Background: Acute lung injury (ALI) is one kind of frequently occurred emergency in Intensive Care Unite with a high mortality. The underlying causes are uncontrolled inflammatory reactions and intractable hypoxemia, which are difficult to control and improve. In the past 10 years, gas medical studies have found that both hydrogen molecules and oxygen molecules have protective effects on acute lung injury by improving inflammatory reactions and hypoxia, respectively. Oxygen is an oxidant and hydrogen is an antioxidant. In this study, we investigated the combined effect of above two‐gas molecular on lipopolysaccharide (LPS) ‐induced acute lung injury. Methods To clarify whether the combination of hydrogen and oxygen could increase or cancel out the protective effect, an ALI mice model induced by intraperitoneal injection of LPS was established, and the degree of lung tissue and mitochondria damage was evaluated based on the pathological sections, inflammatory factors, wet–dry ratio, bronchoalveolar lavage fluid (BALF). Immunohistochemistry, electron microscopy, western blotting and other detection methods also used to evaluate the therapeutic effect on acute lung injury model. Results We observed that the combined protective effect of hydrogen and oxygen was superior to their respective protective effects, and the specific molecular mechanisms of the two therapies might be different. Conclusion Hydrogen plays a more important role in the inflammatory and anti‐apoptosis mechanisms, while oxygen improves hypoxia of the body, and thus, its molecular mechanism may be closely associated to the hypoxia pathways.

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Section: Hydrogen-rich Saline Could Decrease Inflammatory Factors In ...mentioning

confidence: 99%

Hydrogen‐rich and hyperoxygenate saline inhibits lipopolysaccharide‐induced lung injury through mediating NF‐κB/NLRP3 signaling pathway in C57BL/6 mice

Fan

Wang

Feng

et al. 2022

Environmental Toxicology

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“…In this regard, the minimum oxygen concentration that maintains normal arterial oxygen saturation without leading to clinical signs of hypoxia is considered beneficial ( 21 ). Intravenous infusion of a hyper-oxygenated solution has been reported to attenuate ALI by ameliorating the formation of lung edema, lipid peroxidation, and hypoxemia associated with phosgenismus, thereby highlighting a novel protective strategy against ALI ( 65 ).…”

Section: Treatmentmentioning

confidence: 99%

Phosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategies

2022

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Phosgene (COCl2) gas is a chemical intermediate of high-volume production with numerous industrial applications worldwide. Due to its high toxicity, accidental exposure to phosgene leads to various chemical injuries, primarily resulting in chemical-induced lung injury due to inhalation. Initially, the illness is mild and presents as coughing, chest tightness, and wheezing; however, within a few hours, symptoms progress to chronic respiratory depression, refractory pulmonary edema, dyspnea, and hypoxemia, which may contribute to acute respiratory distress syndrome or even death in severe cases. Despite rapid advances in medicine, effective treatments for phosgene-inhaled poisoning are lacking. Elucidating the pathophysiology and pathogenesis of acute inhalation toxicity caused by phosgene is necessary for the development of appropriate therapeutics. In this review, we discuss extant literature on relevant mechanisms and therapeutic strategies to highlight novel ideas for the treatment of phosgene-induced acute lung injury.

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“…Intravenous fluid with a high partial pressure of oxygen (pO 2 ) was shown to improve hypoxia in several animal models [1] , [2] , [3] . Further studies demonstrated that fluids containing high amounts of dissolved oxygen achieved supersaturated oxygen levels in the bloodstream, but special devices were needed to create these fluids [4] , [5] .…”

Section: Datamentioning

confidence: 99%

Data on a simple method for producing a solution that contains a high partial pressure of oxygen and a low partial pressure of carbon dioxide

Tange

Yoshitake

2018

Data in Brief

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The data presented here shows a simple method for producing a solution that contains a high partial pressure of oxygen (pO2) and a low partial pressure of carbon dioxide (pCO2). This novel solution was created by simply injecting oxygen gas into conventional supplemental bicarbonate fluid for renal replacement therapy. We compared the gas profiles of the novel solution and the conventional fluid in vitro. There was a significant increase in pO2 and pH, and a significant decrease in pCO2 in the experimental solution, in each of which an additional volume of oxygen was injected. The method shown here is capable of facilitating an increase of pO2 and decrease of pCO2 by using a closed fluid bag without any special devices.

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Intravenous Administration of Hyperoxygenated Solution Attenuates Pulmonary Edema Formation in Phosgene-Induced Acute Lung Injury in Rabbits

Cited by 10 publications

References 19 publications

Hydrogen‐rich and hyperoxygenate saline inhibits lipopolysaccharide‐induced lung injury through mediating NF‐κB/NLRP3 signaling pathway in C57BL/6 mice

Hydrogen‐rich and hyperoxygenate saline inhibits lipopolysaccharide‐induced lung injury through mediating NF‐κB/NLRP3 signaling pathway in C57BL/6 mice

Phosgene-Induced acute lung injury: Approaches for mechanism-based treatment strategies

Data on a simple method for producing a solution that contains a high partial pressure of oxygen and a low partial pressure of carbon dioxide

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