Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects

Pluess, Thomas-Thi; Hayoz, Daniel; Berger, Mette M.; Tappy, Luc; Revelly, Jean-Pierre; Michaeli, Burkhard; Carpentier, Yvon; Chioléro, René

doi:10.1007/s00134-007-0591-5

Cited by 92 publications

(72 citation statements)

References 34 publications

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“…Human studies, for example, have demonstrated that fish oil attenuated the febrile response to LPS challenge Pluess et al, 2007), and this coincided with significant attenuation of the tumor necrosis factor (TNF)-a response (Pluess et al, 2007). The febrile and TNF-a response to LPS challenge was also attenuated in pigs that were supplemented with n-3 FA in their diet (Gabler et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary fish meal and soybean meal on the ovine innate and acquired immune response during pregnancy and lactation

Stryker

Fisher

You

et al. 2013

Animal

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In recent years, livestock producers have been supplementing animal diets with fish meal (FM) to produce value-added products for health conscious consumers. As components of FM have unique neuroendocrine-immunomodulatory properties, we hypothesize that livestock producers may be influencing the overall health of their animals by supplementing diets with FM. In this study, 40 pregnant ewes were supplemented with rumen protected (RP) soybean meal (SBM: control diet) or RP FM, commencing gestation day 100 (gd100), in order to evaluate the impact of FM supplementation on the innate and acquired immune response and neuroendocrine response of sheep during pregnancy and lactation. On gd135, half the ewes from each diet (n 5 10 FM, n 5 10 SBM) were challenged iv with lipopolysaccharide (LPS) to simulate a systemic bacterial infection and the febrile, respiratory and neuroendocrine responses were monitored over time; the other half (n 5 10 FM, n 5 10 SBM) of the ewes received a saline injection as control. On lactation day 20 (ld20), all ewes ( n 5 20 FM, n 5 20 SBM) were sensitized with hen egg white lysozyme (HEWL) and the serum haptoglobin (Hp) response was measured over time. The cutaneous hypersensitivity response (CHR) to HEWL challenge was measured on ld30 ( n 5 20 FM, n 5 20 SBM), and blood samples were collected over time to measure the primary and secondary immunoglobulin G (IgG) response to HEWL. There was an attenuated trend in the LPS-induced febrile response by the FM treatment when compared with the SBM treatment ( P 5 0.06), as was also true for the respiratory response (P 5 0.07), but significant differences in neuroendocrine function (serum cortisol and plasma ACTH) were not observed between treatments. Basal Hp levels were significantly lower in the FM supplemented ewes when compared with the SBM supplemented ewes ( P , 0.01), and the Hp response to HEWL sensitization differed significantly over time between treatments (P , 0.01). The CHR to HEWL was also significantly attenuated in the FM treatment compared with the SBM (P , 0.01); however, treatment differences in the primary and secondary IgG responses to HEWL were not observed. These results indicate that FM supplementation differentially affects the innate and acquired immune responses in pregnant and lactating sheep compared with a typical SBM diet of commercial flocks. The long-term implications of this immunomodulation warrant further investigation.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary fish meal and soybean meal on the ovine innate and acquired immune response during pregnancy and lactation

Stryker

Fisher

You

et al. 2013

Animal

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“…The trial used the same design as our previous randomized trial comparing two doses of 0.5 g/kg FO versus placebo [4]:…”

Section: Experimental Design and Treatmentmentioning

confidence: 99%

“…In a previous trial we showed that the intravenous administration of two doses of 0.5 g/kg of FO in healthy subjects resulted in a rapid incorporation of EPA and DHA into the platelet membrane phospholipids [4]. This was associated with a significant downregulation of the neuroendocrine responses to endotoxin (LPS), as well as of some components of the inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

“…Oral FO has been shown to exert beneficial effects in patients with inflammatory diseases and elevated cardiovascular risk [1]. While oral administration requires time to achieve these beneficial effects [3], data in volunteers show that the intravenous administration achieves biological effects in a few hours [4]. The development of intravenous lipid emulsions containing FO enables exploring such properties in acute conditions.…”

Section: Introductionmentioning

confidence: 99%

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Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil

et al. 2009

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Objective: To test the dose response effect of infused fish oil (FO) rich in n-3 PUFAs on the inflammatory response to endotoxin (LPS) and on membrane incorporation of fatty acids in healthy subjects. Design: Prospective, sequential investigation comparing three different FO doses. Subjects: Three groups of male subjects aged 26.8 ± 3.2 years (BMI 22.5 ± 2.1). Intervention: One of three FO doses (Omegaven Ò 10%) as a slow infusion before LPS: 0.5 g/kg 1 day before LPS, 0.2 g/kg 1 day before, or 0.2 g/kg 2 h before. Measurements and results: Temperature, hemodynamic variables, indirect calorimetry and blood samples (TNF-a, stress hormones) were collected. After LPS temperature, ACTH and TNF-a concentrations increased in the three groups: the responses were significantly blunted (p \ 0.0001) compared with the control group of the Pluess et al. trial. Cortisol was unchanged. Lowest plasma ACTH, TNF-a and temperature AUC values were observed after a single 0.2 g/kg dose of FO. EPA incorporation into platelet membranes was dose-dependent. Conclusions: Having previously shown that the response to LPS was reproducible, this study shows that three FO doses blunted it to various degrees. The 0.2 g/kg perfusion immediately before LPS was the most efficient in blunting the responses, suggesting LPS capture in addition to the systemic and membrane effects.

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“…In this respect, Christensen and colleagues [39] demonstrated that fish oil feeding can induce an incorporation of DHA into the membranes of granulocytes that is associated with a dose-response increase in HRV and may protect against serious ventricular arrhythmias. In a recent study [40], the intravenous administration of fish oil with ω-3 PUFAs, before endotoxin injection in healthy volunteers, was able to blunt fever response and sympathetic stimulation and enhance vagal tone, estimated with HRV analysis. This reduction was associated with a significant decrease in plasma norepinephrine and adrenocorticotropin hormone (ACTH) levels.…”

Section: Introductionmentioning

confidence: 99%

The Role of Fish Oil Feeding Rich in ω‐3 Polyunsaturated Fatty Acids in Patients with Sepsis and Septic Shock

Papaioannou¹

2017

Sepsis

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Different clinical studies have demonstrated that fish oil, rich in the very-long-chain ω-3 polyunsaturated fatty acids (PUFAs), has immunomodulatory effects, suppressing the production of pro-inflammatory cytokines in diverse groups of critically ill patients. Moreover, such compounds have been found to attenuate the inflammatory response within 2-3 days upon parenteral administration. Recent experimental data suggest that activation of the cholinergic anti-inflammatory pathway constitutes a novel mechanism of such immune-regulatory effects. Since enhanced vagal tone has been associated with decreased cytokine secretion, novel monitoring tools of its activity at the bedside are needed, in order to evaluate nutritional manipulation of inflammatory response in the critically ill. The present chapter provides an overview of the mechanisms of action through which ω-3 PUFA modulates immune response in critically ill patients suffering from sepsis and septic shock. Furthermore, it summarizes the current evidence regarding clinical effects from administration of fish oil rich in ω-3 PUFAs in septic patients. Finally, it presents data that suggest the existence of a continuous interrelation between immune status and autonomic nervous system during systemic inflammation and proposes novel tools of autonomic nervous system monitoring at the bedside, in order to assess pharmacological manipulation of immune response by ω-3 PUFAs in acute illness.

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Intravenous fish oil blunts the physiological response to endotoxin in healthy subjects

Abstract: Results second sentence should read: Fever was higher in the control group than in FO group.

Cited by 92 publications

References 34 publications

Effects of dietary fish meal and soybean meal on the ovine innate and acquired immune response during pregnancy and lactation

Effects of dietary fish meal and soybean meal on the ovine innate and acquired immune response during pregnancy and lactation

Blunting the response to endotoxin in healthy subjects: effects of various doses of intravenous fish oil

The Role of Fish Oil Feeding Rich in ω‐3 Polyunsaturated Fatty Acids in Patients with Sepsis and Septic Shock

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