Intravenous Glucose Tolerance and Plasma Insulin Studies in Small-for-dates Infants

Dune, Marthe A. Le

doi:10.1136/adc.47.251.111

Cited by 30 publications

(14 citation statements)

References 11 publications

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“…More recently, Dweck and Cassady (8) confirmed that hyperglycemia was frequently related to high rate of glucose infusion and demonstrated the fragile nature of glucose metabolism in infants of very low birth weight. In the same way Chance (3) found a diminished K j in a large series of infants weighing less than 1,300 g. Ledune (16) and Soltesz et al (27) demonstrated that in intrauterine mal nourished infants the rate of glucose utilization was much the same as in fullterm newborns after a load of glucose. All the infants studied by these authors were considerably heavier and the conditions of study were dissimilar to our own.…”

Section: Glucose Disappearancementioning

confidence: 59%

“…Stubbe et al (25) pointed out that many SGA infants do not respond after glucose injection and that no gradual increase of insulin secretion with age could be demonstrated. Ledune (16) did not find any response in the nonhypoglycemic SGA infants.…”

Section: Insulin Responsementioning

confidence: 84%

“…We confirmed our previous study (23) of normal prematures of very low birth weight that such prematures are intolerant to glucose. The rate of glucose fall after an intravenous load was very slow compared to that in the full-term new born (16,26). There have been few studies ofK-p in tiny prematures.…”

Section: Glucose Disappearancementioning

confidence: 99%

“…The reasons for this instability in carbohydrate me tabolism are not fully understood, although there are many reports in the litera ture about glucose metabolism and its hormonal regulation in small for date babies. The serum insulin measured during hypoglycemia has been found to be the same or slightly elevated compared to fasting normal babies (11,16).…”

Section: Introductionmentioning

confidence: 98%

“…All the infants studied by these authors were considerably heavier and the conditions of study were dissimilar to our own. Ledune (16) showed that the Kt was higher in hypoglycemic SGA infants than in the normoglycemic. Soltesz et al (27) have found glucose disappearance to be normal or slightly evelated in asymptomatic cases of hypoglycemic SGA infants, whereas in the symptomatic infants the glucose utilization rate was significantly more rapid than normal or asymptomatic hypoglycemic SGA in fants.…”

Section: Glucose Disappearancementioning

confidence: 99%

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Glucose Disappearance Rate, Insulin Response and Growth Hormone Response in the Small for Gestational Age and Premature Infant of Very Low Birth Weight

Ruitton-Uglienco¹

1976

Neonatology

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The purpose of the present investigation was to study the disappearance rate of intravenously administered glucose, plasma insulin, plasma growth hormone (GH) and their responses to an intravenous glucose load in 29 infants who were small for gestational age (SGA). The findings were compared to those in 19 premature babies of similar birth weight who were appropriate for gestational age (AGA); in all the weights were below 2,000 g. The babies were divided in two groups according to their age when tested, at < 24 and 25–48 h. SGA infants cleared glucose more rapidly than AGA infants (p < 0.01) whose clearance rates were similar to those previously reported in normal full-size and full-term newborns. Arterial insulin values before glucose loading were similar in all groups. The insulin response to glucose was poor in both SGA and AGA infants, but there was no significant difference between these two groups of infants. The response in the two groups at 24 and 25–48 h was similar. In 8 SGA babies insulin response was studied shortly after glucose injection to determine β-cell release, but there was no significant difference of insulin level before and after glucose administration. In 5 AGA and 8 SGA babies insulin response was studied simultaneously in portal vein and aorta. In AGA babies the insulin response was completely different in the two vessels with a high response in the vein; on the contrary, in SGA infants response was variable. Growth hormone levels were high before test in SGA and AGA; after a glucose load the plasma GH levels increase, but the response was identical in SGA and AGA.

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Section: Glucose Disappearancementioning

confidence: 59%

Section: Insulin Responsementioning

confidence: 84%

Section: Glucose Disappearancementioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Glucose Disappearancementioning

confidence: 99%

See 3 more Smart Citations

Glucose Disappearance Rate, Insulin Response and Growth Hormone Response in the Small for Gestational Age and Premature Infant of Very Low Birth Weight

Ruitton-Uglienco¹

1976

Neonatology

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Transient hypoglycemia with hyperinsulinemia in a newborn infant with Rubinstein–Taybi syndrome

Wyatt

1990

Am. J. Med. Genet.

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A newborn boy with Rubinstein-Taybi syndrome who had profound neonatal hypoglycemia is presented. The infant was a discordant fraternal twin with intrauterine growth retardation. The hypoglycemia was due to transient hyperinsulinemia, a condition often seen in small-for-gestational-age infants. Neonatal hypoglycemia may be common in infants with Rubinstein-Taybi syndrome, especially if they also have intrauterine growth retardation.

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Neonatal Glucose Metabolism

Cowett¹,

Farrag²

1998

Principles of Perinatal—Neonatal Metabolism

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Intravenous Glucose Tolerance and Plasma Insulin Studies in Small-for-dates Infants

Cited by 30 publications

References 11 publications

Glucose Disappearance Rate, Insulin Response and Growth Hormone Response in the Small for Gestational Age and Premature Infant of Very Low Birth Weight

Glucose Disappearance Rate, Insulin Response and Growth Hormone Response in the Small for Gestational Age and Premature Infant of Very Low Birth Weight

Transient hypoglycemia with hyperinsulinemia in a newborn infant with Rubinstein–Taybi syndrome

Neonatal Glucose Metabolism

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