Intravoxel incoherent motion diffusion-weighted MR imaging of gliomas: feasibility of the method and initial results

Abstract

The IVIM-fitted post-processing of DWI-signal decay in human gliomas could show significantly different values of fractional perfusion-related volume and fast diffusion coefficient between low- and high-grade tumors, which might enable a noninvasive WHO grading in vivo.

On the Reproducibility of Inversion Recovery Intravoxel Incoherent Motion Imaging in Cerebrovascular Disease

“…We have shown that our CVs with smoothing (ie, full width at half maximum ϭ 3 mm) were generally 3 times lower than when no smoothing was applied. When one assesses CVs with no smoothing (f, CV Յ 12.20%; and D, CV Յ 2.34%), it can be observed that CVs are in the same range as in the other studies (ie, f, 5.8%-11.1%; and D, 0.6%-2.1% 12,15,14 ). This finding indicates that the reproducibility of IR-IVIM is like that of conventional IVIM.…”

“…Several groups have investigated the reproducibility of conventional IVIM and have shown good results (eg, low coefficients of variation [CVs]) for both the perfusion volume fraction and parenchymal diffusivity. [12][13][14][15] Thus far, only 1 reproducibility study has been performed on IR-IVIM. This study examined only f and healthy participants.…”

“…[12][13][14][15] In patients with gliomas, CVs of 6.5% and 0.6% in the NAWM outside the tumor mass for f and D were reported, respectively. 12 Furthermore,…”

Utility of Intravoxel Incoherent Motion MR Imaging for Distinguishing Recurrent Metastatic Tumor from Treatment Effect following Gamma Knife Radiosurgery: Initial Experience

“…5,6 Previous reports found that the second approach delivered the most robust and signal-to-noise-enhanced results; therefore, IVIM parameters were calculated by using the second approach in all patients. 7,8 In addition, an ADC measurement was calculated by using bϭ0 and 900 s/mm 2 and a simple monoexponential fit to compare the ADC with the IVIM-derived D.…”

IVIM analysis of brain tumors: an investigation of the relaxation effects of CSF, blood, and tumor tissue on the estimated perfusion fraction

“…IVIM also demonstrated sensitivity in measuring changes in cerebral blood flow under suppression of extravascular water signals in an experimental setting in a rat brain [3]. Recently, the bi-exponential behavior of signal decay in brain tumours was demonstrated, and its clinical application may include tumour grading [4,5] and differentiation of recurrent tumours from post-treatment effects [6].…”