Introduction for the special issue on recent advances in drug delivery across tissue barriers

Mrsny, Randall J.; Brayden, David J.

doi:10.1080/21688370.2016.1187981

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…In local drug delivery, the epithelium is another formidable barrier, in particular for gastrointestinal, respiratory, and transdermal administration. [ 173 ] Anatomically, epithelial cells are linked to one another via intercellular junctions, forming a tightly‐connected layer that separates internal tissues from the external environment to prevent exotic invasion. At the same time, the epithelial barrier allows selective transport of water and other substances necessary for the maintenance of physiological activities.…”

Section: Barriers For Lbnp‐based Nad Delivery and Coping Strategiesmentioning

confidence: 99%

Physiological Barriers and Strategies of Lipid‐Based Nanoparticles for Nucleic Acid Drug Delivery

Hu,

Li,

You

et al. 2023

Advanced Materials

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Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic acid drug (NAD) delivery. Although their clinical applications have achieved success, the NAD delivery efficiency and safety are still unsatisfactory, which are, to a large extent, due to the existence of multi‐level physiological barriers in vivo. It is important to elucidate the interactions between these barriers and LBNPs, which will guide more rational design of efficient NAD vehicles with low adverse effects and facilitate broader applications of nucleic acid therapeutics. In this review, we describe the obstacles and challenges of biological barriers to NAD delivery at systemic, organ, sub‐organ, cellular and subcellular levels. We comprehensively review the strategies to overcome these barriers, mainly including physically/chemically engineering LBNPs and directly modifying physiological barriers by auxiliary treatments. We then discuss the potentials and challenges for successful translation of these preclinical studies into the clinic. In the end, we address a forward look at the strategies on manipulating protein corona (PC), which may pull off the trick of overcoming those physiological barriers and significantly improve the efficacy and safety of LBNP‐based NADs delivery.This article is protected by copyright. All rights reserved

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Section: Barriers For Lbnp‐based Nad Delivery and Coping Strategiesmentioning

confidence: 99%

Physiological Barriers and Strategies of Lipid‐Based Nanoparticles for Nucleic Acid Drug Delivery

Hu,

Li,

You

et al. 2023

Advanced Materials

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Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems

Thotakura

Kaushik

Kumar

et al. 2019

CPD

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Despite the fact that protein and peptide therapeutics are widely employed in the treatment of various diseases, their delivery is posing an unembellished challenge to the scientists. It was discovered that delivery of these therapeutic systems through oral route is easy with high patient compliance. However, proteolytic degradation and absorption through the mucosal epithelium are the barriers in this route. These issues can be minimized by the use of enzyme inhibitors, absorption enhancers, different carrier systems or either by direct modification. In the process of investigation, it was found that transdermal route is not posing any challenges of enzymatic degradation, but, still absorption is the limitation as the outer layer of skin acts as a barrier. To suppress the effect of the barrier and increase the rate of the absorption, various advanced technologies were developed, namely, microneedle technology, iontophoresis, electroporation, sonophoresis and biochemical enhancement. Indeed, even these molecules are targeted to the cells with the use of cell-penetrating peptides. In this review, delivery of the peptide and protein therapeutics using oral, transdermal and other routes is discussed in detail.

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Challenges in Oral Peptide delivery: Lessons Learnt From the Clinic and Future Prospects

Richard

2017

Ther. Deliv.

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Therapeutic peptides have become very successful drugs due to their specificity, potency and low toxicity, but they show challenges for their delivery, due to their short half-life and rapid plasma clearance. For these reasons, peptides are usually administered using injectable sustained-release formulations. Oral peptide route is highly compelling from a patient and commercial point of view. However, poor peptide stability and low permeability across the intestinal epithelium still make it very challenging to effectively deliver peptides by the oral route. In this paper, biopharmaceutical and formulation features of oral peptides, as well as key clinical outcomes, are reviewed and discussed in the perspective of designing next generation of oral peptide formulations for a true paradigm shift.

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Introduction for the special issue on recent advances in drug delivery across tissue barriers

Cited by 3 publications

References 16 publications

Physiological Barriers and Strategies of Lipid‐Based Nanoparticles for Nucleic Acid Drug Delivery

Physiological Barriers and Strategies of Lipid‐Based Nanoparticles for Nucleic Acid Drug Delivery

Advanced Approaches of Bioactive Peptide Molecules and Protein Drug Delivery Systems

Challenges in Oral Peptide delivery: Lessons Learnt From the Clinic and Future Prospects

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