Introduction to Department of Defense Center for Prostate Disease Research Multicenter National Prostate Cancer Database, and analysis of changes in the PSA-era

Sun, Leon; Gancarczyk, Kevin J; Paquette, Edmond L.; McLeod, David G.; Kane, Christopher J.; Kusuda, Leo; Lance, Raymond S.; Herring, Judi; Foley, John P.; Baldwin, Dalton; Bishoff, Jay T.; Soderdahl, Douglas W.; H, Wu; Xu, Linda; Moul, Judd W.

doi:10.1016/s1078-1439(01)00145-4

Cited by 48 publications

(17 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A description of this cohort and related data collection activities has been described previously [19, 20]. The study sample was restricted to patients diagnosed with CaP between January 1, 1989, and December 31, 2008, and for whom initial treatment was AS.…”

Section: Methodsmentioning

confidence: 99%

Racial/Ethnic Patterns in Prostate Cancer Outcomes in an Active Surveillance Cohort

et al. 2011

View full text Add to dashboard Cite

Introduction. Concern regarding overtreatment of prostate cancer (CaP) is leading to increased attention on active surveillance (AS). This study examined CaP survivors on AS and compared secondary treatment patterns and overall survival by race/ethnicity. Methods. The study population consisted of CaP patients self-classified as black or white followed on AS in the Center for Prostate Disease Research (CPDR) multicenter national database between 1989 and 2008. Secondary treatment included radical prostatectomy (RP), external beam radiation therapy or brachytherapy (EBRT-Br), and hormone therapy (HT). Secondary treatment patterns and overall survival were compared by race/ethnicity. Results. Among 886 eligible patients, 21% were black. Despite racial differences in risk characteristics and secondary treatment patterns, overall survival was comparable across race. RP following AS was associated with the longest overall survival. Conclusion. Racial disparity in overall survival was not observed in this military health care beneficiary cohort with an equal access to health care.

show abstract

Section: Methodsmentioning

confidence: 99%

Racial/Ethnic Patterns in Prostate Cancer Outcomes in an Active Surveillance Cohort

et al. 2011

View full text Add to dashboard Cite

show abstract

“…1 This early detection of the disease has led to concern that many clinically insignificant prostate cancers will be detected. Moreover, the pretreatment clinical staging of prostate cancer is important due to the increasing use of non-surgical treatment options.…”

Section: Introductionmentioning

confidence: 99%

Percentages of positive cores, cancer length and Gleason grade 4/5 cancer in systematic sextant biopsy are all predictive of adverse pathology and biochemical failure after radical prostatectomy

et al. 2007

View full text Add to dashboard Cite

Aim:We investigated whether the quantitative parameters of systematic sextant biopsies were predictive of either adverse pathological findings or disease recurrence after radical prostatectomy (RP). Methods: We retrospectively evaluated a total of 117 men with untreated prostate cancer whose needle biopsies were matched with RP specimens. The pretreatment parameters of the serum prostate-specific antigen (PSA), the PSA density, the percentage of positive biopsy cores, the percentage of cancer length and the percentage of Gleason grade 4/5 cancer in the biopsy were determined and compared with the pathological features of prostate cancer in RP specimens. These pretreatment parameters and pathological factors in the RP specimens, including the cancer volume, the percentage of Gleason grade 4/5 cancer, the positive surgical margin and the seminal vesicle invasion were evaluated for their ability to predict the disease recurrence. Results: The percentages of positive biopsy cores, the Gleason grade 4/5 cancer in the biopsy and the cancer length in the biopsy had a weak correlation with the cancer volume in RP specimens (r = 0.373, 0.345, 0.408, respectively). All quantitative biopsy parameters were strongly predictive of the non-organ-confined status, the positive surgical margin and the seminal vesicle invasion in the logistic regression analysis. The percentage of positive biopsy cores and the percentage of Gleason grade 4/5 cancer in the biopsy predicted biochemical failure after RP. Conclusion:These results indicate that quantitative biopsy parameters are independent predictors of the adverse pathology of prostate cancers and disease recurrence after RP.

show abstract

“…They found that 70% of the prostate cancers they detected with PSA screening were pathologically organ confined, in contrast to 51% in the referred population from the same institution. According to the Center for Prostate Disease Research (CPDR) 36 Data from other American registries also documented age-adjusted incidences of distant metastasis being reduced by approximately 50%. 37 It is believed that a decrease in the rate of distant metastasis will precede a decrease in mortality, as there is no cure for metastatic disease.…”

Section: Stage Migrationmentioning

confidence: 99%

Prostate-specific Antigen Testing and Prostate Cancer Screening

Djavan

Eckersberger

Finkelstein

et al. 2010

Primary Care: Clinics in Office Practice

View full text Add to dashboard Cite

Introduction to Department of Defense Center for Prostate Disease Research Multicenter National Prostate Cancer Database, and analysis of changes in the PSA-era

Cited by 48 publications

References 17 publications

Racial/Ethnic Patterns in Prostate Cancer Outcomes in an Active Surveillance Cohort

Racial/Ethnic Patterns in Prostate Cancer Outcomes in an Active Surveillance Cohort

Percentages of positive cores, cancer length and Gleason grade 4/5 cancer in systematic sextant biopsy are all predictive of adverse pathology and biochemical failure after radical prostatectomy

Prostate-specific Antigen Testing and Prostate Cancer Screening

Contact Info

Product

Resources

About