Introduction to DIN-specification 91315 based on the characterization of the plasma jet kINPen® MED

Mann, Miriam; Tiede, Regina; Gavénis, Karsten; Daeschlein, Georg; Bussiahn, R.; Weltmann, Klaus‐Dieter; Emmert, Steffen; Woedtke, Thomas von; Ahmed, Raees

doi:10.1016/j.cpme.2016.06.001

Cited by 92 publications

(106 citation statements)

References 42 publications

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“…The pictures of the "effluent" in Figure 2a were acquired for five different plasma power values from 1.7 W to 2.6 W according to equation (3). The emission of the "effluent" is dominated by atomic argon lines close to the nozzle, while for longer effluents the diffusion of ambient air species is increasing causing band emission of molecular nitrogen [15].…”

Section: Resultsmentioning

confidence: 99%

“…3b), the species densities (also of byproducts like ozone), the irradiance (also in the UV range) and the patient leakage current. In order to stay compliant with medical regulations, such a change needs to be checked regarding these and further parameters [3].…”

Section: -P3mentioning

confidence: 99%

“…While the basic research on biological effects in this field is meanwhile well established, the physics of the plasma sources itself must be well understood in order to explain the treatment effects and to address safety issues [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Power measurement for an atmospheric pressure plasma jet at different frequencies: distribution in the core plasma and the effluent

Gerling

Brandenburg

Wilke

et al. 2017

Eur. Phys. J. Appl. Phys.

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Abstract. The characterization of electrical power distribution in an atmospheric pressure plasma jet operated at six different frequencies is investigated by measurement of input power and voltage-charge plots for the core plasma and the plasma in the effluent. The frequency change is further characterized by measuring the temperature in the effluent at different positions and input power levels. The power input into the core plasma is limited to about 1 W for a wide range of frequencies while the total input power and thus the power input into the effluent increases continuously with frequency.

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Section: Resultsmentioning

confidence: 99%

Section: -P3mentioning

confidence: 99%

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Power measurement for an atmospheric pressure plasma jet at different frequencies: distribution in the core plasma and the effluent

Gerling

Brandenburg

Wilke

et al. 2017

Eur. Phys. J. Appl. Phys.

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“…[9] In addition, Brehmer reported that the CAP (DBD, line voltage: 230 VAC, 50 Hz, maximum power consumption: 8 VA) treatment was safe and effective in patients with chronic venous leg ulcers. [13] Also, no convenient criteria for the standardization of the quality rating of plasma in view of dermatological applications exist. [11] Arndt reported that treatment with a Micro-PlaSter cold plasma (microwave 2.45 GHz, 110 W, argon flow rate 4.0 L/min, treatment diameter 5 cm) activated the production of wound-healing-related molecules in dermal fibroblasts and resulted in wound healing improvement.…”

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confidence: 99%

Effects and mechanisms of cold atmospheric plasma on skin wound healing of rats

Zhang

Guo

Chen

et al. 2018

Contributions to Plasma Physics

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Cold atmospheric plasma (CAP) has been reported as a novel potential way to promote skin wound healing. The aim of this study was to explore the effects of an atmospheric-pressure plasma generated in helium gas through dielectric barrier discharge on skin wound healing in rats and its mechanism. A total of 44 adult male Sprague-Dawley rats were divided into the CAP group and the control group after a full-thickness skin wound model was established. The animals in the CAP group received CAP treatment (driving frequency 17 kHz, root-mean-square [rms] values of the discharge voltage 1.33 kV, rms values of the discharge current 10.7 mA, helium flow rate 11 slpm [standard litres per minute]) for 1 min. After that, the size of the healed area of the wound, morphological changes in the wound, wound neovascularization, collagen deposition, and the level of inflammatory factors were recorded. The results showed that compared to that of the control group, the size of the wound area in the CAP group significantly decreased, the contraction and re-epithelialization of the wounds were obviously speeded up, and the protein level of smooth muscle actin markedly increased. However, the levels of collagen type I A2, collagen type III, and the deposition of collagen bundles did not change. In addition, it was found that the level of inflammatory factors (such as tumour necrosis factor and interleukin-1 ) significantly increased at 24 hr after the creation of the wound. These results suggest that CAP treatment in this condition could promote skin wound healing by accelerating the contraction, re-epithelialization, neovascularization, and inflammatory response.

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“…Osim toga, kINPen 09 je korišten u mnogobrojnim biološko-medicinskim ispitivanjima i primjenama 18,19 . Poboljšana verzija kINPen-a 09, kINPen MED, je prvi APPJ s dozvolom za primjenu na ljudima s posebnom namjenom za dermatologiju te je jedan od prvih CAP instrumenta detaljno okarakteriziran prema specifikaciji 91315 njemačkog instituta za standardizaciju, nazvanoj "Opći zahtjevi za izvore plazme koji se primjenjuju u medicini" 5,20 . APPJ kINPen radi u kontinuiranom ili pulsnom modu, pri čemu se najčešće koriste He, Ar ili zrak sa standardnim protokom od 5 slm.…”

Section: Plazma U Fiziciunclassified

Plasma applications in medicine and dentistry

Mance

2017

Med. flum.

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Sažetak. U fizici, plazma je ioniziran, kvazineutralan plin za koji se često kaže da je četvrto stanje materije. Dugo vremena se plazma u medicini koristila zbog svojih termalnih svojstava, primjerice za sterilizaciju kirurškog i medicinskog pribora te za rezanje i kauterizaciju tkiva. Generiranjem hladne plazme u atmosferskim uvjetima započelo je novo razdoblje u primjeni plazme u biomedicini. Plazma medicina novo je interdisciplinarno znanstveno područje koje kombinira spoznaje fizike plazme s biomedicinskim i kliničkim znanostima. Hladna atmosferska plazma emitira elektromagnetno zračenje te se sastoji od mnoštva nabijenih i nenabijenih čestica, među kojima su najznačajnije reaktivne kisikove i dušikove vrste. Smatra se da su upravo reaktivne kisikove vrste najvažnije za biološke učinke plazme kao što su inaktivacija mikroorganizama i biofilmova. U dermatologiji se pokazalo da hladna atmosferska plazma pozitivno utječe na zacjeljivanje kroničnih rana. Prvi instrumenti za primjenu hladne plazme na ljudima već su i komercijalno dostupni. Primjena hladne plazme ima velik potencijal za primjenu u onkologiji, ali i u stomatologiji. Mnogobrojne studije dale su vrlo obećavajuće rezultate za primjenu hladne plazme u medicini, no treba imati na umu da mehanizmi međudjelovanja plazme s biološkim tkivom još uvijek nisu u potpunosti razjašnjeni, da nema dogovorom prihvaćene definicije doze koju plazma predaje materiji, da još uvijek nema standardiziranih instrumenata za generiranje i karakterizaciju plazme te da za pravu procjenu potencijala primjene atmosferske plazme u medicini i stomatologiji nedostaje više detaljnih in vivo studija.Ključne riječi: dermatologija; onkologija; plazma; stomatologija Abstract. Physical plasma is an ionized, quasi-neutral gas. It is often said to be the fourth state of matter. For a long time, plasma was used in medicine exclusively because of its thermal properties for sterilization purposes of surgical equipment and medical supplies, and also to cut and cauterize tissue. The possibility to generate cold plasma in atmospheric conditions marked the beginning of a completely new era in the application of plasma in biomedicine. Plasma medicine is a new interdisciplinary field of science that combines the knowledge of plasma physics to biomedical and clinical sciences. Cold atmospheric plasma emits electromagnetic radiation and it consists out of charged and uncharged particles, among those reactive oxygen and nitrogen species are the most important ones. It is considered that reactive oxygen species cause the most important biological plasma effects, such as inactivation of microorganisms and biofilms. It has been shown in dermatology that cold atmospheric plasma has a healing effect on chronic wounds. First instruments for the application of cold plasma in humans are already commercially available. Cold plasma has a great potential for application in oncology and in dentistry. Numerous studies have yielded very promising results for the application of cold plasma in medicine, but it should ...

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Introduction to DIN-specification 91315 based on the characterization of the plasma jet kINPen® MED

Cited by 92 publications

References 42 publications

Power measurement for an atmospheric pressure plasma jet at different frequencies: distribution in the core plasma and the effluent

Power measurement for an atmospheric pressure plasma jet at different frequencies: distribution in the core plasma and the effluent

Effects and mechanisms of cold atmospheric plasma on skin wound healing of rats

Plasma applications in medicine and dentistry

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