Introduction to Epigenetic Inheritance: Definition, Mechanisms, Implications and Relevance

Lassi, Maximilian; Teperino, Raffaele

doi:10.1007/978-3-030-35213-4_9

Cited by 2 publications

(1 citation statement)

References 92 publications

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“…It has shown that it can provide a heritable effect transferred between generations. Similarly, studies included inhabitants of Överkalix, their children and grandchildren in the northern Swedish city, who experienced irregular famine during WW II, showed that grandparents' nutrition just before puberty was associated with transgenerational (gender-specific) phenotypes 15 . Therefore, objecting the GGI because of "heritability" or "affecting future generations" does not constitute a valid and sufficient ethical argument on its own, since it is not an exceptional case specific to germline genetic interventions.…”

Section: Nd Assumption Of Heritability Argument: "Heritability Is Specific To Ggi"mentioning

confidence: 99%

An Ethical Reflection on the Heritability Argument in the Germline Genetic Intervention Debate

Barış

2021

Int. J. Hum. Health Sci.

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Germline genetic intervention (GGI) has been one of the most discussed topics within the bioethics literature since 2012, when the programming of CRISPR/Cas9 for a specifically targeted gene region has become possible. While some authors are optimistic about what GGI may offer, others strongly disagree and refute the use of this technology for different reasons. This paper will aim to examine one of the most widespread arguments against GGI, namely “heritability” argument, comprehensively. Firstly, it will aim to examine the moral importance of the germline. Secondly, it will try to understand three possible assumptions of the heritability argument. Then it will try to respond to these assumptions and argue that they are neither scientifically supportable nor rationally solid for rejecting GGI altogether.International Journal of Human and Health Sciences Vol. 05 No. 04 October’21 Page: 405-411

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Section: Nd Assumption Of Heritability Argument: "Heritability Is Specific To Ggi"mentioning

confidence: 99%

An Ethical Reflection on the Heritability Argument in the Germline Genetic Intervention Debate

Barış

2021

Int. J. Hum. Health Sci.

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What Is Epigenetic Change and What Do We Know About Its Impact on Molecular Pathologic Mechanisms of the Diseases?

BOZKURT

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et al. 2022

SDÜ Tıp Fakültesi Dergisi

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Epigenetik değişiklik, kromatin modifikasyonu, DNA metilasyonu, histon modifikasyonu, kromatin düzenleyici proteinler ve kodlamayan RNA'lar yoluyla meydana gelmekte olup, kalıcı genotipik değişiklik olmaksızın gerçekleşen fenotipik bir değişikliği ifade eder. Transkripsiyon sonrası m6A RNA metilasyonu da yeni tanımlanmış bir epigenetik mekanizma olup, yeni bir tanısal biyobelirteç ve potansiyel terapötik hedef olduğuna inanılmaktadır. Epigenetik değişikliklerin birçok nonneoplastik ve neoplastik hastalığın gelişiminde ve ilerlemesinde önemli bir rol oynadığı iyi bilinen bir gerçektir. Bu nedenle epigenetik değişiklikler tanısal ve prognostik açıdan değerlidir. Öte yandan kişiselleştirilmiş tıp ve hedefe yönelik tedavi yaklaşımlarının gelişmesiyle birlikte epigenetik değişiklikleri hedefleyen tedavi stratejileri birçok hastalık için umut verici bir alan haline gelmektedir. Bu derlemenin amacı, epigenetik değişikliklerin mekanizmaları ve neoplastik / nonneoplastik hastalıkların gelişimindeki rolleri hakkında klinisyenlere ve laboratuvar tıbbı uzmanlarına daha sonraki araştırmalar için yardımcı olabilecek bilgiler sağlamaktır.

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Introduction to Epigenetic Inheritance: Definition, Mechanisms, Implications and Relevance

Cited by 2 publications

References 92 publications

An Ethical Reflection on the Heritability Argument in the Germline Genetic Intervention Debate

An Ethical Reflection on the Heritability Argument in the Germline Genetic Intervention Debate

What Is Epigenetic Change and What Do We Know About Its Impact on Molecular Pathologic Mechanisms of the Diseases?

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