Introduction to the Feature Section on “Crohn’s disease activity: MRI assessment and clinical implications”

Maccioni, Francesca

doi:10.1007/s00261-012-9874-6

Cited by 3 publications

(6 citation statements)

References 27 publications

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“…Maccioni ve ark. [16] yaptığı bir çalışmada, duyarlığın "prone" pozisyonunda % 66,8, "supine" pozisyonunda ise %63 olduğu gösterilmiştir. Biz ise çalışmamızda alışılagelmiş olan "supine" pozisyonu tercih ettik.…”

Section: Discussionunclassified

Diagnostic value of MR enterography for the assessment of small-bowel diseases

Allahverdiyev¹,

Koplay²,

Erdoğan³

et al. 2017

Archives of Clinical and Experimental Medicine

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ÖzAmaç: Bu çalışmamızda kolay elde edilebilen ve iyi bir bağırsak distansiyonu sağlayan %3 mannitol ile manyetik rezonans (MR) enterografi yönteminin tanısal etkinliğinin değerlendirilmesini amaçlıyoruz. Yöntemler: Yaşları 7-71 yıl arasında değişen 42 hasta çalışmaya dahil edildi. MR enterografi protokolü 1.5 Tesla MRG (Magnetom Aera; SiemensMedical Solutions, Erlangen, Germany) cihazı ile yapıldı. Bulgular cerrahi-fiberoptik kolonoskopiden elde edilen histopatolojik sonuçlarla karşılaştırıldı. Duyarlılık, özgüllük, pozitif ve negatif öngörü değerleri, tanısal doğruluk oranı istatiksel olarak hesaplandı. Bulgular: Duyarlılık %83, özgüllük %93, pozitif öngörü değeri %83, negatif öngörü değeri %93 ve tanısal doğruluk oranı %90 olarak saptanmıştır. Yalancı negatif olan iki hasta radyolojik olarak normal değerlendirildi, ancak patolojik inceleme nonspesifik inflamasyon olarak geldi. Yalancı pozitif olan bir hastada patolojik inceleme ülseratif kolit olarak, bir hastada ise invajinasyona neden olan ektopik pankreas dokusuna ait polipoid kitle saptandı. Gerçek pozitif olan dokuz hastada patoloji sonucu Crohn hastalığı, diğer hastada ise tipik olmamakla birlikte Crohn hastalığı lehine değerlendirildi. Ayrıca Crohn hastalığ ile takip edilen bir hastada iki yerde ince bağırsak segment tutulumu, diğer bir hastada da ileoileal fistül izlendi. Sonuç: MR enterografi, Crohn hastalığının takibinde, hastalığın aktif sürecindeki inflamasyonun, fibrostenoz evredeki striktürlerin, obstrüksiyonların, komplikasyonların belirlenmesinde ve tedavi seçeneğinin değerlendirilmesinde önemlidir. Gelecekte, mevcut MR sekansları ve yeni geliştirilen sekans teknikleriyle yapılacak geniş hasta katılımlı karşılaştırmalı çalışmalara ihtiyaç vardır. MR, ince bağırsağın diğer hastalıklarının değerlendirilmesinde de umut vericidir. Anahtar Kelimeler: MR enterografi, Crohn hastalığı, Mannitol Abstract Aim: We aim to evaluate the diagnostic efficiency of magnetic resonance (MR) enterography and mannitol %3 which have been gathered easily and provide good intestine distension. Methods: 42 patients whose ages are between 7 and 71 have been included in the project. MR enterography protocol has been done by 1.5 Tesla MRG (Magnetom Aera, Siemens Medical Solutions, Erlangen, Germany) device. Findings were compared to histopathological results obtained by surgery and fiberoptic endoscopy. Sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy rate have been calculated statistically. Results: Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy rate were calculated as 83%, 93%, 83%, 93% and 90%, respectively. Two patients with false negative results were evaluated as normal in the radiologic manner but pathologic investigation came as nonspecific inflammation. Pathologic investigation was recognized as ulcerative colitis for a patient with false positive result and in another patient with false positive result, invagination caused by a polypoid bulky mass due to the ectopic ...

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Section: Discussionunclassified

Diagnostic value of MR enterography for the assessment of small-bowel diseases

Allahverdiyev¹,

Koplay²,

Erdoğan³

et al. 2017

Archives of Clinical and Experimental Medicine

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“…С их помощью можно получить изображение стенки кишки в продоль-ном и поперечном сечении, оценить просвет и со-стояние стенки кишки, висцеральной жировой клетчатки, артериальных и венозных сосудов, лимфоузлов. Исходя из материалов последних публикаций, в США отдается предпочтение ме-тоду КТ, в Европе более широко используют УЗИ и МРТ [11,18]. Из методов первичной диагности-ки ВЗК тонкой кишки УЗИ считается самым до-ступным, распространенным и недорогим мето-дом, особенно у детей.…”

Section: лекция обзорunclassified

“…Методу нет равных в распознавании перианальных про-явлений, определении хода свища относительно анального сфинктера, обнаружении недрени-рованных гнойников, что может быть полезно в оценке фармакологического лечения свищевой формы болезни Крона [69]. МРТ на доопераци-онном этапе позволяет выполнить адекватную коррекцию аноректальных поражений, благода-ря чему в дальнейшем частота рецидивов свищей снижается почти на 75% [18].…”

Section: диагностическая точностьunclassified

The potential of radiologic procedures in the diagnosis of inflammatory bowel disease

Дуброва

Stashuk

2016

Alʹm. klin. med.

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“…They are thickness of wall, the degree of wall gadolinium- (Gd-) enhancement, T2 mural signal intensity, enhancement of local lymph nodes, pattern of wall Gd-enhancement, increased mesenteric vascularity, and time-enhancement curves of Gd-wall enhancement. Each of these parameters has proved to be statistically correlated with the biological, endoscopic, or histological activity [ 21 , 51 – 53 ].…”

Section: Mri For Cd: Presentmentioning

confidence: 99%

“…However, they do not provide dynamic metabolic status of tissue and whole organism [ 67 ]. MR molecular imaging and MR spectroscopy (MRS) are still experimental but promising, because they are some of the leading technologies in metabolomics and have possibility to analyze and characterize the molecular composition of inflamed bowel wall [ 51 ]. As MRS has more accurate quantitation and better reproducibility than mass spectrometry, MRS is already routinely used in many malignant conditions such as brain, breast, and prostate cancer [ 68 ].…”

Section: Mri For Cd: Futurementioning

confidence: 99%

MRI for Crohn’s Disease: Present and Future

Yoon

Chang

Lee

2015

BioMed Research International

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Crohn's disease (CD) is a chronic inflammatory condition with relapsing-remitting behavior, often causing strictures or penetrating bowel damage. Its lifelong clinical course necessitates frequent assessment of disease activity and complications. Computed tomography (CT) enterography has been used as primary imaging modality; however, the concern for radiation hazard limits its use especially in younger population. Magnetic resonance (MR) imaging has advantages of avoiding radiation exposure, lower incidence of adverse events, ability to obtain dynamic information, and good soft-tissue resolution. MR enterography (MRE) with oral contrast agent has been used as primary MR imaging modality of CD with high sensitivity, specificity, and interobserver agreement. The extent of inflammation as well as transmural ulcers and fibrostenotic diseases can be detected with MRE. Novel MR techniques such as diffusion-weighted MRI (DWI), motility study, PET-MRI, and molecular imaging are currently investigated for further improvement of diagnosis and management of CD. MR spectroscopy is a remarkable molecular imaging tool to analyze metabolic profile of CD with human samples such as plasma, urine, or feces, as well as colonic mucosa itself.

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Introduction to the Feature Section on “Crohn’s disease activity: MRI assessment and clinical implications”

Cited by 3 publications

References 27 publications

Diagnostic value of MR enterography for the assessment of small-bowel diseases

Diagnostic value of MR enterography for the assessment of small-bowel diseases

The potential of radiologic procedures in the diagnosis of inflammatory bowel disease

MRI for Crohn’s Disease: Present and Future

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