Introduction to the Study on Regeneration in Lizards as an Amniote Model of Organ Regeneration

Alibardi, Lorenzo

doi:10.3390/jdb9040051

Cited by 1 publication

(1 citation statement)

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“…The complexity spans feedback mechanisms to ensure balance between stem cell maintenance and regeneration; the gradient of signaling molecules across the niche that dictates the behavioral phase of stem cells; serotonin accumulation at neural injury indicating involvement of neurotransmitters; the immune system which favors regeneration; spatial orientation, i.e., spatial cell memory; and neural signals which, for example, play a crucial role in limb regeneration in lizards. If the nerve is severed in the tail, regeneration is impaired [151][152][153]. In zebrafish heart regeneration, the ablation of epicardial niches housing muscle progenitors severely impair the regenerative response [154].…”

Section: Decoding Nature's Masters Of Regeneration: Insights Into Nic...mentioning

confidence: 99%

Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases

Velikic,

Maric,

Maric

et al. 2024

IJMS

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Regenerative medicine harnesses the body’s innate capacity for self-repair to restore malfunctioning tissues and organs. Stem cell therapies represent a key regenerative strategy, but to effectively harness their potential necessitates a nuanced understanding of the stem cell niche. This specialized microenvironment regulates critical stem cell behaviors including quiescence, activation, differentiation, and homing. Emerging research reveals that dysfunction within endogenous neural stem cell niches contributes to neurodegenerative pathologies and impedes regeneration. Strategies such as modifying signaling pathways, or epigenetic interventions to restore niche homeostasis and signaling, hold promise for revitalizing neurogenesis and neural repair in diseases like Alzheimer’s and Parkinson’s. Comparative studies of highly regenerative species provide evolutionary clues into niche-mediated renewal mechanisms. Leveraging endogenous bioelectric cues and crosstalk between gut, brain, and vascular niches further illuminates promising therapeutic opportunities. Emerging techniques like single-cell transcriptomics, organoids, microfluidics, artificial intelligence, in silico modeling, and transdifferentiation will continue to unravel niche complexity. By providing a comprehensive synthesis integrating diverse views on niche components, developmental transitions, and dynamics, this review unveils new layers of complexity integral to niche behavior and function, which unveil novel prospects to modulate niche function and provide revolutionary treatments for neurodegenerative diseases.

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Section: Decoding Nature's Masters Of Regeneration: Insights Into Nic...mentioning

confidence: 99%

Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases

Velikic,

Maric,

Maric

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Introduction to the Study on Regeneration in Lizards as an Amniote Model of Organ Regeneration

Abstract: Initial observations on the regeneration of the tail in lizards were recorded in brief notes by Aristotle over 2000 years ago, as reported in his book, History of Animals (cited from [...]

Cited by 1 publication

References 61 publications

Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases

Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases

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