Introductory Chapter: Biogenic Amines in Neurotransmission and Human Disease from the Endocrinologist’s Perspective

Uçar, Ahmet

doi:10.5772/intechopen.89244

Cited by 1 publication

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References 10 publications

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“…17 Biogenic amine neurotransmitters, such as dopamine, norepinephrine, epinephrine, histamine, and serotonin, participate in various types of physiological functions, such as regulating cognitive abilities, mood, etc. 18 – 20 According to research, biogenic amines are intriguing possibilities for being key autointoxication mediators that might be implicated in the development of depressive symptoms, anxiety (neuroticism), and perhaps psychosis. 21 , 22 Norepinephrine, serotonin, and dopamine have been mostly investigated in relation to antisocial behavior.…”

Section: Introductionmentioning

confidence: 99%

Association between dopamine receptor D2 Taq IA gene polymorphism (rs1800497) and personality traits

Olasore,

Oyedeji,

Faleti

et al. 2024

SAGE Open Medicine

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Objective: This study aimed to find a potential association between the DRD2 Taq1A gene polymorphism (rs1800497 C32806T) and personality traits. Methods: In all, 249 youths were recruited for this study. The Short-form Revised Eysenck Personality Questionnaire was administered to assess personality traits. The participants were genotyped for the DRD2 Taq1A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method. Statistical analysis was carried out to find a possible association between the genotypes and aspects of personality traits assessed. Results: The frequencies of the A1 and A2 alleles in our sampled population were 215 (43.2%) and 283 (56.8%), while the frequencies of A1A1, A1A2, and A2A2 were 67 (26.9%), 81 (32.5%), and 101 (40.6%), respectively. The study population was not in Hardy-Weinberg equilibrium ( χ2 = 17.64, p < 0.001). The A2 allele was significantly associated with extraversion. Although this allele was also associated with neuroticism, psychoticism, and lie, the association was not significant. Conclusion: The A2 allele of the DRD2 Taq1A polymorphism was found to be more associated with extraversion, as measured by the Short-form Revised Eysenck Personality Questionnaire.

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