INTS-MFS: A novel method to predict microRNA-disease associations by integrating network topology similarity and microRNA function similarity

Predicting miRNA-disease association through combining miRNA function and network topological similarities based on MINE

“…A miRNA function similarity network is a complex network ( Cao et al., 2021 , 2022 ; Xiao et al., 2018 ). The present work analyzed and calculated the miRNA network similarity, which is described as follows: …”

“…Using several features (e.g., similarities, weights, functions) can effectively compensate for the shortcoming of a single feature in a biological network ( Cao et al., 2021 , 2022 ; Chen et al., 2019a ; Ding et al., 2018 ; Wang et al., 2021a ) and improve the quality of predicted results. In this study, miRNA function similarity and network topological similarity were combined.…”

“…Inspired by ( Cao et al., 2022 ; Rhrissorrakrai and Gunsalus, 2011 ), a method called combination between miRNA function similarities and network topology similarities based on module identification algorithm in networks (ComSim-MINE) was developed to predict miRNA–disease association from the viewpoint of function module. The innovation of this study is that the miRNA function interaction network is constructed from the harmonic mean between miRNA function similarities and network topology similarities.…”