Intussusceptions as acute abdomen caused by Burkitt lymphoma: a case report

Hoxha, Faton; Hashani, Shemsedin I; Krasniqi, Avdyl; Kurshumliu, Fisnik; Komoni, Driton S; Hasimja, Shpresa Mehmet; Maxhuni, Mehmet

doi:10.1186/1757-1626-2-9322

Cited by 17 publications

(17 citation statements)

References 18 publications

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“…Sporadic Burkitt's is accounting for 1%-2% of adults lymphoma and up to 40% children lymphoma in the United States and Western Europe [17,21] . Estimated incidence for children under 10 years old 1 per million, for ages 10-20 years old is 0.7 per million, for 20-30 …”

Section: Discussionmentioning

confidence: 99%

“…patient had ileal resection and ileoileal anastomosis, pathology showed a tumor 4 cm in diameter blocked ileum completely and infiltrated serosa。 years ages is 0.6 per million and very rare in patients older than 30 years old [17,22,23] . Burkitt's lymphoma is an aggressive, highly malignant and rapidly growing B-cell neoplasm.…”

Section: Figurementioning

confidence: 99%

“…in case of erosion of a large vessel the symptoms of acute gastrointestinal hemorrhage, in cases of small bowel perforation symptoms of acute peritonitis, in cases of small bowel lumen obstruction symptoms of acute intestinal obstruction could appear [24] . Intussusception caused by Burkitt's lymphoma, as a cause of acute abdomen, is rare, with symptoms which often mislead and make diagnosis more difficult [17,25] . Presenting symptoms in the sporadic forms are abdominal swelling due to large mesenteric retroperitoneal or pelvic mass, tenderness, pain, ileo-cecal intussusception related symptoms of bowel obstructions [17,23,26] .…”

Section: Figurementioning

confidence: 99%

“…The sporadic form tends to present in the lymphoid tissues of the gut. The disease present as masses in the waldeyer ring or the terminal ileum, or even with involvement of abdominal organs with the most involvement of the distal ileum, cecum or mesentery [1] . BL is a highly aggressive and fast growing B-cell malignancy presenting in non-endemic BL regions.…”

Section: Introductionmentioning

confidence: 99%

“…BL is a highly aggressive and fast growing B-cell malignancy presenting in non-endemic BL regions. BL cause intussusception rarely, appears as acute abdomen and diagnosis is difficult due to mislead symptoms [1] . The disease present itself as abdominal pain, nausea, and intestinal obstruction due to direct compression or result of intussusception of the bowel lumen.…”

Section: Introductionmentioning

confidence: 99%

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Burkitt's Lymphoma Causing Intussusception in Adults:Report of two Cases and Review of the Literature

Yağmur

Gümüş

2015

Journal of Gastroenterology and Hepatology Research

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BACKGROUND: Burkitt's lymphoma (BL) related intussusception causing intestinal obstruction in adults is very rare. Two cases of BL related ileocecal intussusception were operated in our clinic and treatment options were explained with previous literature. PATIENTS AND METHOD:The English medical literature in the PubMed and Google Scholar databases was reviewed for adult related ileocecal intussusception, and 10 reports concerning 10 cases of intussusception due to BL were noticed. Our presented two cases of BL related ileocecal intussusception were 17 and 19 years old and both male. both operated due to acute abdomen. RESULTS: The patients printed in the literature were aged from 16 to 52 years. According to the localization of lymphoma, 6 patients had ileo-colic intussusception, 2 had ileal, and 2 had colic intussusception. In terms of the diagnosis, 10 patients were diagnosed with computerized tomography (CT). Our patient one was 17 years old male complaining from abdominal pain, distention and not passing gas and flatus, having rebound and tenderness on the abdomen. Bowel sounds were increased and abdomen was distended. Laboratory values were normal. Patient was HIV negative and EBV was negative. CT showed" target"-shaped soft-tissue mass with a layering effect of ileo-colic intussusception. At exploration ileum was invaginated through ileocecal valve to cecum. Cecum mass about 5 cm in diameter was noticed. Right hemicolectomy and ileocolic anastomosis was performed. Macroscopy showed 6×5.5 cm polypoid tumor formation blocked the lumen. A few lymph node with the largest 2.5×2 cm were dissected in the mucosa. On immunohistochemical studies; CD20 in CD10 staining were observed strong positive staining. TdT, CD23, CD5 and bcl-2 staining were not observed. Ki-67 proliferation index was evaluated as 100%. Tumor involvement was observed diagnosis was BL. Our other patient 19 years male patients with abdominal pain and constipation. There was no history of weight loss or fever. Physical examination showed defans and rebound in the right lower quadrant of abdomen in both patients. Bowel sounds were increased. No evidence of any lymph nodes during systematic examination appeared. Laboratory values were normal with negative HIV. In situ hybridization for EB virus was negative forms of sporadic BL. Intravenous contrast for abdominal tomography was taken and A "sausage"-shaped soft tissue mass with ileo-colic intussusception appeared. 4 cm mass in the terminal ileum was palpated. patient had ileal resection and ileoileal anastomosis. Pathology showed a tumor 4 cm in diameter blocked ileum completely and infiltrated serosa of ileum. immunohistochemical studies CD20, CD10 staining were positive, CD3, CD5, CD23, bcl-6 and TdT staining were negative. Ki-67 proliferation index was 100%. Burkitt's lymphoma was diagnosed in the location of terminal ileum. Both patients was discharged with good bowel movements without any complication and referred to the hematology for chemotherapy treatment. Complete resection is very i...

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Burkitt's Lymphoma Causing Intussusception in Adults:Report of two Cases and Review of the Literature

Yağmur

Gümüş

2015

Journal of Gastroenterology and Hepatology Research

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Burkitt lymphoma as a lead point for jejunojejunal intussusception in a human immunodeficiency virus patient

Sharma

Balasingham

Stawiarski

et al. 2017

Clin J Gastroenterol

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Intussusception is commonly seen in children but is rare in adults and represents only 5% of all intussusceptions causing 1% of intestinal obstructions. More than 50% of these intussusceptions in adults are due to intestinal neoplasms, including malignant lymphoma, e.g., Burkitt lymphoma. These lymphomas are more common in human immunodeficiency virus (HIV)-positive patients than in the general population. We present a case of a young male who was diagnosed with HIV when he developed intestinal obstruction and intussusception secondary to Burkitt lymphoma. He was managed with surgical resection followed by chemotherapy and antiretroviral treatment. HIV patients presenting with acute abdomen pose a diagnostic challenge to clinicians due to a wide range of differential diagnoses including inflammatory, infectious and neoplastic conditions. In a young HIV patient presenting with acute abdomen, intussusception caused by Burkitt lymphoma should be considered in the differential.

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Invaginación ileocólica en un paciente infectado por el virus de la inmunodeficiencia humana

Pernas

Calvo

et al. 2014

Gastroenterología y Hepatología

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Intussusceptions as acute abdomen caused by Burkitt lymphoma: a case report

Cited by 17 publications

References 18 publications

Burkitt's Lymphoma Causing Intussusception in Adults:Report of two Cases and Review of the Literature

Burkitt's Lymphoma Causing Intussusception in Adults:Report of two Cases and Review of the Literature

Burkitt lymphoma as a lead point for jejunojejunal intussusception in a human immunodeficiency virus patient

Invaginación ileocólica en un paciente infectado por el virus de la inmunodeficiencia humana

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