Invadosomes in real life

Saltel, Frédéric

doi:10.4161/cam.28969

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…Cellular protrusions are F-actin-rich matrix-degrading structures of migrating and invading cells at points of cell-matrix contacts. These protrusions were found in highly motile cells of mesenchymal lineages [ 33 ] and cell types subjected to stress [ 63 ]. We here document a gas plasma-driven modulation of cellular protrusions by spatial and temporal regulation of various protrusion markers (e.g., WASp, ARPC, and CTTN).…”

Section: Discussionmentioning

confidence: 99%

Gas plasma-spurred wound healing is accompanied by regulation of focal adhesion, matrix remodeling, and tissue oxygenation

et al. 2021

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In response to injury, efficient migration of skin cells to rapidly close the wound and restore barrier function requires a range of coordinated processes in cell spreading and migration. Gas plasma technology produces therapeutic reactive species that promote skin regeneration by driving proliferation and angiogenesis. However, the underlying molecular mechanisms regulating gas plasma-aided cell adhesion and matrix remodeling essential for wound closure remain elusive. Here, we combined in vitro analyses in primary dermal fibroblasts isolated from murine skin with in vivo studies in a murine wound model to demonstrate that gas plasma treatment changed phosphorylation of signaling molecules such as focal adhesion kinase and paxillin α in adhesion-associated complexes. In addition to cell spreading and migration, gas plasma exposure affected cell surface adhesion receptors (e.g., integrinα5β1, syndecan 4), structural proteins (e.g., vinculin, talin, actin), and transcription of genes associated with differentiation markers of fibroblasts-to-myofibroblasts and epithelial-to-mesenchymal transition, cellular protrusions, fibronectin fibrillogenesis, matrix metabolism, and matrix metalloproteinase activity. Finally, we documented that gas plasma exposure increased tissue oxygenation and skin perfusion during ROS-driven wound healing. Altogether, these results provide critical insights into the molecular machinery of gas plasma-assisted wound healing mechanisms.

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Section: Discussionmentioning

confidence: 99%

Gas plasma-spurred wound healing is accompanied by regulation of focal adhesion, matrix remodeling, and tissue oxygenation

et al. 2021

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“…Invadosomes or invadopodia are actin-rich structures with structural and functional similarities to podosomes, which drive cell migration and invasion [24,25]. Invadosomes are normally associated with tumor cell motility, as a molecular mechanism co-opted and deregulated from normal cells [26,27].…”

Section: Introductionmentioning

confidence: 99%

“…The underlying molecular mechanisms that lead to these effects, which might depend on cell type and nanoparticle surface charge and shape [22], are nonetheless poorly understood. Several parameters involved in tumor cell migration might be affected by nanoparticle treatment either directly, such as downmodulation of factors that induce cell death or immobilization, or indirectly via other processes such as mitochondrial respiration mechanism [23], which influence cytoskeletal rearrangement.Invadosomes or invadopodia are actin-rich structures with structural and functional similarities to podosomes, which drive cell migration and invasion [24,25]. Invadosomes are normally associated with tumor cell motility, as a molecular mechanism co-opted and deregulated from normal cells [26,27].…”

mentioning

confidence: 99%