Invasive Aspergillosis

Fisher, Bruce D.; Armstrong, Donald; Yu, Bessie; Gold, Jonathan W. M.

doi:10.1016/0002-9343(81)90208-4

Cited by 264 publications

(14 citation statements)

References 7 publications

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“…In several large series (Degregorio et al, 1983;Fisher et al, 1981;Meyer et al, 1973;Young et al, 1970) ofpatients with malignancy and aspergillosis, leukaemia was the underlying diagnosis in 52%. To our knowledge disseminated aspergillosis has not been recorded as a complication following therapy of a primary brain tumour.…”

Section: Discussionmentioning

confidence: 99%

“…The portal ofentry of the fungus is usually the lungs (Fisher et al, 1981), and evidence of primary infection in this site is found in 90% of cases, only 10% having primary extrapulmonary disease. Our patient is difficult to classify in these terms, her cerebral lesions were the most extensive but she did have a small pulmonary infarct.…”

Section: Discussionmentioning

confidence: 99%

“…It is usually made on bronchoscopy or lung biopsy of infected tissue, obviously impossible in this case with no evidence of pulmonary disease. Sputum examination is unreliable as a guide to invasive disease (Fisher et al, 1981), but a conversion of aspergillus serology may have been helpful. A CT scan performed a week before death failed to reveal any evidence of cerebral abscess, infarct or tumour.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment of the more common pulmonary disease is slightly more successful. In one series (Fisher et al, 1981) 10 of 91 patients had their disease eradicated in the lungs using similar drugs. The major problem is in recognition of the disease before massive dissemination has occurred, as by that time treatment is usually unsuccessful.…”

Section: Discussionmentioning

confidence: 99%

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Disseminated aspergillosis following radiation therapy for medulloblastoma

Hamilton

Darbyshire

McKeever

et al. 1985

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Disseminated aspergillosis following radiation therapy for medulloblastoma

Hamilton

Darbyshire

McKeever

et al. 1985

Postgraduate Medical Journal

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“…It is very difficult to distinguish between invasive fungal sinusitis and sphenoid sinus FB when the disease is accompanied by a visual disturbance because a visual disturbance can be a symptom of invasive fungal sinusitis [21]. However, vision and eye movements can also be disturbed by neuritis, compression, or ischemic infarctions resulting from thrombophlebitis of the optic nerves in isolated cases of sphenoid sinus disease.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Sphenoid Sinus Fungal Ball Patients With Visual Disturbance

Kim

Hong

et al. 2016

Clin Exp Otorhinolaryngol

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ObjectivesA sphenoid sinus fungal ball is a rare disease that can cause visual disturbances. Most afflicted patients remain in an indolent state. However, once the visual disturbance has occurred, the recovery rate is very low. The purpose of this study was to overview the clinical characteristics of patients with a sphenoid sinus fungal ball and ascertain factors possibly related to the occurrence of a visual disturbance.MethodsWe retrospectively reviewed the medical records of all patients who underwent endoscopic sinus surgery for a sphenoid sinus fungal ball at our hospital. We enrolled 47 patients in this study.ResultsOld age and a female predominance were noted. Nasal symptoms were the most common symptom. Eight patients showed visual disturbances. We also compared the clinical characteristics between patients with and without visual disturbances in univariate analysis. Old age, underlying diabetes mellitus, and a sphenoid sinus wall defect visible by computed tomography were factors significantly related to the occurrence of visual disturbances. But only sphenoid sinus wall defect showed significance in multivariate analysis.ConclusionIt is important to prevent complications, such as visual disturbance, in patients with a sphenoid sinus fungal ball. This study describes an early surgical treatment that may be required for patients with a sphenoid sinus fungal ball and particularly patients with a sphenoid sinus wall defect.

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Cutaneous Rhizopus and Aspergillus Infections in Five Patients With Cancer

Khardori

Hayat

Rolston³

et al. 1989

Arch Dermatol

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Primary cutaneous infection with Aspergillus species and Rhizopus species was observed in five patients between October 1986 and January 1988. All patients had an underlying hematological malignancy and were neutropenic. Four patients developed skin lesions with eschars at and around the site of intravenous catheter insertion. One patient had two lesions along the course of the intravenous line. The fifth patient developed the lesion on the left side of the lower part of the back subsequent to the appearance of a rash due to excessive perspiration. A diagnosis was made in each case by histopathological studies and cultures of skin biopsy specimens. The fungal organisms cultured were Aspergillus species in three patients and Rhizopus species in two patients. All patients were treated with amphotericin B. Three patients responded to antifungal therapy and local care without surgical débridgement. Two patients died of disseminated fungal infection. The development of cutaneous lesions due to opportunistic fungal pathogens seemed to have been related to the moist and humid conditions created by occlusive dressings or excessive perspiration.

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Invasive Aspergillosis

Cited by 264 publications

References 7 publications

Disseminated aspergillosis following radiation therapy for medulloblastoma

Disseminated aspergillosis following radiation therapy for medulloblastoma

Clinical Characteristics of Sphenoid Sinus Fungal Ball Patients With Visual Disturbance

Cutaneous Rhizopus and Aspergillus Infections in Five Patients With Cancer

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