Invasive candidiasis: future directions in non-culture based diagnosis

Posch, Wilfried; Heimdörfer, David; Wilflingseder, Doris; Lass‐Flörl, Cornelia

doi:10.1080/14787210.2017.1370373

Cited by 24 publications

(18 citation statements)

References 106 publications

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“…For example, a single miRNA can regulate from one to multiple genes, whereas studies have also shown that multiple miRNAs can regulate the same gene ( 27 – 30 ). Several miRNAs, as well as miRNA families, have been extensively studied and have been characterized in models of cancer, heart disease, aging, apoptosis, and immune responses to inflammatory stimuli ( 19 , 20 , 31 – 34 ).…”

Section: Micrornasmentioning

confidence: 99%

MicroRNA Regulation of Host Immune Responses following Fungal Exposure

et al. 2018

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Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miRNAs) following fungal exposure and is overlooked, yet important, group of regulators capable of influencing fungal immune responses through a variety of cellular mechanisms. These small non-coding ribose nucleic acids function to regulate gene expression at the post-transcriptional level and have been shown to participate in multiple disease pathways including cancer, heart disease, apoptosis, as well as immune responses to microbial hazards and occupational allergens. Recent animal model studies have characterized miRNAs following the exposure to inflammatory stimuli. Studies focused on microbial exposure, including bacterial infections, as well as exposure to different allergens have shown miRNAs, such as miR-21, miR-146, miR-132, miR-155, and the let-7 family members, to be involved in immune and inflammatory responses. Interestingly, the few studies have assessed that the miRNA profiles following fungal exposure have identified the same critical miRNAs that have been characterized in other inflammatory-mediated and allergy-induced experimental models. Review of available in vitro, animal and human studies of exposures to Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Paracoccidioides brasiliensis, and Stachybotrys chartarum identified several miRNAs that were shared between responses to these species including miR-125 a/b (macrophage polarization/activation), miR-132 [toll-like receptor (TLR)2-mediated signaling], miR-146a (TLR mediated signaling, alternative macrophage activation), and miR-29a/b (natural killer cell function, C-leptin signaling, inhibition of Th1 immune response). Although these datasets provide preliminary insight into the role of miRNAs in fungal exposed models, interpretation of miRNA datasets can be challenging for researchers. To assist in navigating this rapidly evolving field, the aim of this review is to describe miRNAs in the framework of host recognition mechanisms and provide initial insight into the regulatory pathways in response to fungal exposure.

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Section: Micrornasmentioning

confidence: 99%

MicroRNA Regulation of Host Immune Responses following Fungal Exposure

et al. 2018

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“…For this method, DNA is ampli ied by the iso or non-iso thermal method. (Posch et al, 2017) Future trends…”

Section: Nucleic Acid-based Assaysmentioning

confidence: 99%

A Review on Candidiasis resistance current drug development process in its prevention and treatment

Guruprasad

Gowda

2020

ijrps

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A fungal infection caused by Candida albicans leads to illness and death worldwide. This review mainly focused upon Vulvovaginal Candidiasis that is a common fungal infection seen in women, especially during pregnancy; Candida species cause diseases, particularly in immunocompromised patients. This type of infection occurred during the nonsterile environment. The different types of candidiasis mentioned in this review are Mucosal Candidiasis, Oropharyngeal Candidiasis, Vulvovaginal Candidiasis, Cutaneous Candidiasis, Invasive Candidiasis, Disseminated candidiasis, and Candidemia. New approaches like vaccination, antibodies, cytokine therapy, amphotericin-B loaded nanofiber, mucoadhesive are required to improve the result of the patients suffering from infections. New insights into the mechanism of anticandidal host response have contributed to the design of novel immunotherapy. The systemic and topical treatment is carried. The novel drug therapy is given in order to avoid the resistivity developed by fungus. Diagnosis is made by different techniques like direct examination and Culture Method. The other examination methods used are Pathogen-related tests, mannan tests, nucleic acid-based assays. Amphotericin–B loaded nanofibers and liposomes are developed and even certain plant extracts are using as an antifungal drug which is safer to use the future trends used for the study are Echinocandins, the latest class of drug used for the antifungal and drug act as a fungicidal that has low drug-drug interaction which makes first-line treatment for invasive candidiasis particularly. The different class of drugs has been used for the treatment are discussed with Azoles that are used in the treatment with a combination of the other class drugs.

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“…The last decade has seen a renewed importance in pathogen identication due to advancements in biosensors 1,2 and microuidics. [3][4][5][6] Owing to advantages like less sample volume consumption, cost-effectiveness, facile operating procedure, ease of multiplexing with potential automation and portability in nature, microuidic platforms are regarded as a trailblazer in wide range of elds. 7,8 Traditionally, microuidic devices are constructed using glass and polymeric materials like polymethyl methacrylate, polydimethyl siloxane, polyethylene terephthalate etc.…”

Section: Introductionmentioning

confidence: 99%