Invasive candidiasis

Lass-Flörl, Cornelia; Kanj, Souha S.; Govender, Nelesh P.; Thompson, George R.; Ostrosky- Zeichner, Luis; Govrins, Miriam Alisa

doi:10.1038/s41572-024-00503-3

Cited by 30 publications

(4 citation statements)

References 184 publications

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“…Microbial infections have emerged as a significant global concern, with the Candida albicans species being one of the most prevalent fungal strains found on human mucosal membranes [ 126 ]. This yeast can attach to epithelial tissues, resulting in superficial infections commonly referred to as candidiasis.…”

Section: Resultsmentioning

confidence: 99%

“…Vural et al [115] found that the essential oil extracted from olive leaves displayed a highly intriguing volatile composition, showcasing potent antibacterial activity [115]. Vegetal extract Ø = 13-18.5 mg/mL MIC = 12.5-25 mg/mL MBC = 25-50 mg/mL [102,105] Leaves Essential oil Ø = 9-29 mm MIC = 0.625-5 mg/mL [6,96,115,117] Vegetal extract Ø = 1-20 mm MIC = 0.60-25 mg/mL MBC = 0.70-12.5 mg/mL [109,110,[118][119][120][121][122][123][124][125][126][127] Ø = zone of inhibition; MIC = minimum inhibition concentration; MBC = minimum bactericidal concentration; GN = Gram negative; GP = Gram positive.…”

Section: Antibacterial Activitymentioning

confidence: 99%

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Comprehensive Review of Olea europaea: A Holistic Exploration into Its Botanical Marvels, Phytochemical Riches, Therapeutic Potentials, and Safety Profile

Elhrech,

Aguerd,

El Kourchi

et al. 2024

Biomolecules

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Human health is now inextricably linked to lifestyle choices, which can either protect or predispose people to serious illnesses. The Mediterranean diet, characterized by the consumption of various medicinal plants and their byproducts, plays a significant role in protecting against ailments such as oxidative stress, cancer, and diabetes. To uncover the secrets of this natural treasure, this review seeks to consolidate diverse data concerning the pharmacology, toxicology, phytochemistry, and botany of Olea europaea L. (O. europaea). Its aim is to explore the potential therapeutic applications and propose avenues for future research. Through web literature searches (using Google Scholar, PubMed, Web of Science, and Scopus), all information currently available on O. europaea was acquired. Worldwide, ethnomedical usage of O. europaea has been reported, indicating its effectiveness in treating a range of illnesses. Phytochemical studies have identified a range of compounds, including flavanones, iridoids, secoiridoids, flavonoids, triterpenes, biophenols, benzoic acid derivatives, among others. These components exhibit diverse pharmacological activities both in vitro and in vivo, such as antidiabetic, antibacterial, antifungal, antioxidant, anticancer, and wound-healing properties. O. europaea serves as a valuable source of conventional medicine for treating various conditions. The findings from pharmacological and phytochemical investigations presented in this review enhance our understanding of its therapeutic potential and support its potential future use in modern medicine.

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Section: Resultsmentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

Comprehensive Review of Olea europaea: A Holistic Exploration into Its Botanical Marvels, Phytochemical Riches, Therapeutic Potentials, and Safety Profile

Elhrech,

Aguerd,

El Kourchi

et al. 2024

Biomolecules

View full text Add to dashboard Cite

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“…The relationship between Candida albicans and oral cancer is considered exceptionally close, as recurrent oral Candida infections and oral ulcers are among the manifestations of this malignancy (Stoopler et al, 2024). Candida albicans adheres to oral mucosa and forms biofilms, thus inducing a yeast-to-hypha transition, ultimately penetrating oral epithelial cells and inflicting long-term tissue damage, which elicits chronic inflammatory responses (Akpan and Morgan, 2002;Lass-Flörl et al, 2024). Microbial infection-induced chronic inflammation is acknowledged as a significant risk factor for tumor progression.…”

Section: Treatmentmentioning

confidence: 99%

Worldwide trend in research on Candida albicans and cancer correlations: a comprehensive bibliometric analysis

Tang,

Xu,

2024

Front. Microbiol.

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ObjectiveCandida albicans (C. albicans), an opportunistic pathogen, is implicated in the carcinogenesis of various cancers, thereby significantly impacting human health. This study conducts an in-depth analysis of the prevailing research dynamics concerning the relationship between C. albicans and cancer over the past decade, offering a comprehensive overview of the knowledge structure and emerging focal points in this field through bibliometric scrutiny.MethodsA methodical quantitative and visual scrutiny of pertinent literature from the Web of Science Core Collection (WoSCC) spanning the previous decade was carried out employing VOS Viewer and CiteSpace software.ResultsFrom January 1, 2014, to January 1, 2024, a comprehensive corpus of 1,259 articles was delineated. Prominent research institutions included the Egyptian Knowledge Bank, Cairo University, and King Saud University. The top three prolific countries were the United States, China, and India. Among the authors, Mohamed, Gehad G., Mahmoud, Walaa H., and Netea, Mihai G., emerged as the most prolific, with Pfaller, Ma being distinguished as the most frequently cited author. The journal Molecules published the highest number of articles, while PLoS One had the highest citation count. Nature had the highest impact factor. The research focal points in this field encompassed the interactions between C. albicans and cancer, the correlation with oral cancer, the underlying mechanisms of C. albicans carcinogenic potential, as well as antifungal and anticancer therapies.ConclusionThis investigation constitutes a pioneering bibliometric analysis elucidating the trends and advancements in research regarding the correlation between C. albicans and cancer. Said analyses uncover the prevailing research focal points and trends, offering insightful guidance for subsequent inquiry in this domain.Systematic review registrationhttps://www.webofscience.com/wos/woscc/summary/df33afba-f843-41e8-b932-cb3678eb8243-e92e7316/relevance/1

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“…and in case of Gram-negative BSI when severe and/or high-inoculum infections, non-eradicable foci or immunosuppressed patients [28]. Documentation of microbiological clearance is crucial in the case of candidemia to establish treatment duration [29]. For sure, the indiscriminate use of FUBCs in uncomplicated Gram-negative BSI does not seem to exert a beneficial effect, on the contrary, potentially driving an increase in the length of stay [30], but in the presence of complicated forms the achievement of microbiological eradication should be determined to appropriately monitor response.…”

Section: Catheter-related Bloodstream Infections (Crbsis) Complicated...mentioning

confidence: 99%

Short Course Antibiotic Therapy for Catheter-Related Septic Thrombosis: “Caveat Emptor!”: Duration of Therapy Should Not Be Set a Priori

Maraolo,

Ceccarelli,

Venditti

et al. 2024

Pathogens

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There is a growing body of evidence showing no significant difference in clinical outcomes in patients with uncomplicated Gram-negative bloodstream infections (BSIs) receiving 7 or 14 days of therapy. However, the scenario may differ when complicated forms of BSI, such as catheter-related BSIs (CRBSIs) burdened by septic thrombosis (ST), are considered. A recent study showed that a short course of antimicrobial therapy (≤3 weeks) had similar outcomes to a prolonged course on CRBSI-ST. From this perspective, starting from the desirable goal of shortening the treatment duration, we discuss how the path to the correct diagnosis and management of CRBSI-ST may be paved with several challenges. Indeed, patients with ST due to Gram-negative bacteria display prolonged bacteremia despite an indolent clinical course, requiring an extended course of antibiotic treatment guided by negative FUBCs results, which should be considered the real driver of the decision-making process establishing the length of antibiotic therapy in CRBSI-ST. Shortening treatment of complicated CRBSIs burdened by ST is ambitious and advisable; however, a dynamic and tailored approach driven by a tangible outcome such as negative FUBCs rather than a fixed-duration paradigm should be implemented for the optimal antimicrobial duration.

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Invasive candidiasis

Cited by 30 publications

References 184 publications

Comprehensive Review of Olea europaea: A Holistic Exploration into Its Botanical Marvels, Phytochemical Riches, Therapeutic Potentials, and Safety Profile

Comprehensive Review of Olea europaea: A Holistic Exploration into Its Botanical Marvels, Phytochemical Riches, Therapeutic Potentials, and Safety Profile

Worldwide trend in research on Candida albicans and cancer correlations: a comprehensive bibliometric analysis

Short Course Antibiotic Therapy for Catheter-Related Septic Thrombosis: “Caveat Emptor!”: Duration of Therapy Should Not Be Set a Priori

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