Invasive pneumococcal disease: From a tertiary care hospital in the post-vaccine era

Başaranoğlu, Sevgen Tanır; Öncel, Eda Karadağ; Aykaç, Kübra; Özsürekçi, Yasemin; Cengiz, Ali Bülent; Kara, Ateş; Ceyhan, Mehmet

doi:10.1080/21645515.2016.1256519

Cited by 6 publications

(7 citation statements)

References 9 publications

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“…19 In the literature, several cases were reported of those who had IPD due to PCV13 serotypes despite having received at least two doses of PCV vaccination. [20][21][22][23][24][25][26][27][28] There is a lack of information about the risk of IPD with vaccine-types after completing the recommended course of PCV immunization. After the vaccination, the changes of antibody titers against serotypes affect the serotype distribution of IPD besides the serotype carriage.…”

Section: Discussionmentioning

confidence: 99%

Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018

Ceyhan

Aykaç

Gürler

et al. 2020

Human Vaccines & Immunotherapeutics

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Objectives: To determine the serotype distribution of pneumococcus causing invasive pneumococcal disease (meningitidis, bacteremia and empyema) in children in Turkey, and to observe potential changes in this distribution in time to guide effective vaccine strategies. Methods: We surveyed S. pneumoniae with conventional bacteriological techniques and with real-time polymerase chain reaction (RT-PCR) in samples of cerebrospinal fluid (CSF), blood and pleural fluid. S. pneumoniae strains were isolated from 33 different hospitals in Turkey, which are giving health services to approximately 60% of the Turkish population. Results: A total of 167 cases were diagnosed with invasive pneumococcal disease between 2015 and 2018. We diagnosed 52 (31.1%) patients with meningitis, 104 (62.2%) patients with bacteremia, and 11 (6.6%) patients with empyema. Thirty-three percent of them were less than 2 years old and 56% less than 5 years old. Overall PCV13 serotypes accounted for 56.2% (94/167). The most common serotypes were 19 F (11.9%), 1 (10.7%) and 3 (10.1%). Conclusions: Besides the increasing frequency of non-vaccine serotypes, vaccine serotypes continue to be a problem for Turkey despite routine and high-rate vaccination with PCV13 and significant reduction reported for the incidence of IPD in young children. Since new candidate pneumococcal conjugate vaccines with more serotype antigens are being developed, continuing IPD surveillance is a significant source of information for decision-making processes on pneumococcal vaccination.

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Section: Discussionmentioning

confidence: 99%

Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018

Ceyhan

Aykaç

Gürler

et al. 2020

Human Vaccines & Immunotherapeutics

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“…Antimicrobial resistance causes different clinical presentation of disease, making it more difficult to diagnose and to treat. 11 12 The patient's clinic and laboratory features were not compatible with IRAK-4 or MyD88 deficiencies. According to our knowledge, a case of PNP in a child fully immunized has not been reported in literature.…”

Section: Discussionmentioning

confidence: 95%

Necrotizing pneumonia caused by Streptococcus pneumoniae serotype 3 despite PCV13

et al. 2019

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Streptococcus pneumoniae is the most common cause of complicated pneumonia. Pneumococcal necrotizing pneumonia (PNP) is a rare and serotype related complication. Serotypes 1, 3, 14, 15, 19A and 33 were the most reported serotypes in children with PNP before immunization. Despite widespread vaccination, S. pneumoniae is still cause of invasive diseases. We reported a child, fully immunized with 13-valent conjugated pneumococcal vaccine (PCV13) who was diagnosed PNP due to serotype 3. Breakthrough invasive infection caused by S. pneumoniae must be considered in mind despite fully vaccination.

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“…18 There are cases of infection reported despite vaccination. Basaranoglu et al 19 reported infection with 19 F strains despite vaccination in two patients. Both patients had underlying neurologic deficits.…”

Section: Discussionmentioning

confidence: 99%

“…One of the patients had a pneumonia infection, and the other had meningitis. 19 Park et al 20 found an infection rate of 21% despite vaccination. The serotypes most commonly causing infection were 6B and 19F.…”

Section: Discussionmentioning

confidence: 99%

A case of fulminant pneumococcus meningoencephalitis progressing with white matter involvement despite two doses of conjugated pneumococcus vaccine

et al. 2020

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Background. Streptococcus pneumonia is a cause of serious mortality and morbidity, especially among small children. However, currently, it causes lower rates of invasive infections due to successful vaccination programs Case. We report an exceptional case of a 6-month-old child with meningoencephalitis caused by Streptococcus pneumonia despite the administration of two doses of pneumococcal conjugate vaccine (PCV). Meningitis progressed rapidly and led to widespread damage in parenchymal brain tissue with the emergence of fulminant meningoencephalitis. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed widespread brain lesions, suggesting extensive parenchymal injury. Conclusion. Such diffuse white matter lesions among pediatric patients with Streptococcus pneumonia meningoencephalitis despite two doses of PCV have not been reported previously.

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Invasive pneumococcal disease: From a tertiary care hospital in the post-vaccine era

Cited by 6 publications

References 9 publications

Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018

Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018

Necrotizing pneumonia caused by Streptococcus pneumoniae serotype 3 despite PCV13

A case of fulminant pneumococcus meningoencephalitis progressing with white matter involvement despite two doses of conjugated pneumococcus vaccine

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