Invasive Pneumococcal Infections in Denmark from 1995 to 1999: Epidemiology, Serotypes, and Resistance

Konradsen, Helle Bossen; Kaltoft, Margit S.

doi:10.1128/cdli.9.2.358-365.2002

Cited by 62 publications

(51 citation statements)

References 26 publications

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“…The incidence among Greenland Inuit older than 35 years is comparable to that seen among the elderly in Denmark (9). As indicated by serotyping, the coverage rate by the 23-valent vaccine should be 94 %.…”

Section: Discussionmentioning

confidence: 86%

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Invasive pneumococcal disease in Greenland

Christiansen

Poulsen²,

Ladefoged³

2004

International Journal of Circumpolar Health

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Section: Discussionmentioning

confidence: 86%

“…Furthermore, it has been shown that 12F is more invasive than other serotypes, being found more frequently among CSF isolates (9).…”

Section: Discussionmentioning

confidence: 99%

Invasive pneumococcal disease in Greenland

Christiansen

Poulsen²,

Ladefoged³

2004

International Journal of Circumpolar Health

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“…It is one of the few pneumococcal serotypes associated with outbreaks of disease in small or closed communities (3,4,11,12,18,20,22,26), and increases in serotype 1 disease have been associated with nationwide increases in invasive disease (14,16). Three recent reports have indicated that serotype 1 pneumococci are the most common cause of complicated pneumonia and pulmonary empyema in children (2,7,28), and serotype 1 has been associated with rare disease syndromes such as peritonitis and salpingitis in adolescent girls (19,25,30).…”

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confidence: 99%

Geographic Distribution and Clonal Diversity of Streptococcus pneumoniae Serotype 1 Isolates

2003

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Serotype 1 pneumococci are a major cause of serious disease and have been associated with outbreaks but are rarely carried. The high attack rate and lack of coverage of this serotype by the heptavalent conjugate vaccine prompted the characterization of a geographically diverse collection of 166 serotype 1 isolates from recent cases of invasive disease. The isolates were resolved by multilocus sequence typing into 16 clones, which clustered into three major lineages with very different geographic distributions. Lineage A isolates were exclusively from Europe and North America, lineage B isolates were predominantly from Africa and Israel, and lineage C isolates were mainly from Chile. There was no clear association between the presence of individual clones within a country and the prevalence of serotype 1 disease.

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“…Serotype 1 ranks among the most prevalent invasive serotypes in many countries (Garcia et al, 2006;Konradsen & Kaltoft, 2002;McChlery et al, 2005;Porat et al, 2001). In Brazil, since 1977, serotype 1 has been identified as one of the most frequent pneumococci causing severe infections in both adult and paediatric patients (Brandileone et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Molecular assessment of invasive Streptococcus pneumoniae serotype 1 in Brazil: evidence of clonal replacement

Chiou

Andrade

Almeida

et al. 2008

Journal of Medical Microbiology

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In Brazil, serotype 1 Streptococcus pneumoniae is one of the most prevalent causes of severe infection. This study investigated the genetic relatedness of 134 serotype 1 isolates obtained from invasive diseases during the period . Molecular typing by PFGE revealed two major lineages using visual inspection and computer analysis. Type A comprised 94 isolates (70.2 %) with four subtypes, whereas type B comprised 40 isolates (29.8 %) with eight subtypes. Subtype A3, the most frequent genotype, accounting for 65 % of the total isolates, was identified as a representative of clone Sweden 1 -40 (ST304). Type B was predominant in the period [1977][1978][1979][1980][1981][1982][1983][1984][1985][1986][1987][1988]. In contrast, an increase in the type A lineage was detected from 1990 in Brazil, significantly associated with isolates recovered from pneumonia cases and from young patients. This study clearly established a temporal switch between two lineages of S. pneumoniae serotype 1 in Brazil, with a wide dispersion of clone Sweden 1 -40 in recent years. INTRODUCTIONThe polysaccharide capsule of Streptococcus pneumoniae can be used to define more than 90 pneumococcal serotypes, in addition to acting as the primary virulence determinant for this organism. Some serotypes are mostly associated with nasopharyngeal carriage, whilst others are more likely to be the causative agents of invasive disease (Alannee et al., 2007;Hausdorff et al., 2005).Serotype 1 ranks among the most prevalent invasive serotypes in many countries (Garcia et al., 2006;Konradsen & Kaltoft, 2002;McChlery et al., 2005;Porat et al., 2001). In Brazil, since 1977, serotype 1 has been identified as one of the most frequent pneumococci causing severe infections in both adult and paediatric patients (Brandileone et al., 2003). In the period 2000-2005, serotype 1 isolates were ranked fourth (5.6 %) among the principal serotypes identified in Brazilian children up to 6 years of age, preceded by serotypes 14 (35.9 %), 6B (11 %) and 18C (6.1 %) (Pan-American Health Organization, 2007).Serotype 1 has specific epidemiological features, including: (i) a low colonization frequency, even in populations in which serotype 1 is a frequent cause of pneumococcal infections (Laval et al., 2006;Normark et al., 2001;Nunes et al., 2008); (ii) the ability to cause outbreaks in communities and in crowded and closed institutions (Dagan et al., 2000;Leimkugel et al., 2005); (iii) an association with severe episodes of pneumonia and empyema in children (Byington et al., 2006); and (iv) susceptibility to most antimicrobial agents (Klugman & Koornhof, 1988). Recently, some authors have speculated that isolates of serotype 1, which are known to have a highly invasive potential, behave as primary pathogens, whereas other capsular types demonstrate opportunistic features (Garau & Calbo, 2007;Hausdorff, 2007). Molecular typing studies have greatly contributed to epidemiological investigations of pneumococci, mostly focusing on the global spread of penicillin-resistant clones (Brueggem...

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Invasive Pneumococcal Infections in Denmark from 1995 to 1999: Epidemiology, Serotypes, and Resistance

Cited by 62 publications

References 26 publications

Invasive pneumococcal disease in Greenland

Invasive pneumococcal disease in Greenland

Geographic Distribution and Clonal Diversity of Streptococcus pneumoniae Serotype 1 Isolates

Molecular assessment of invasive Streptococcus pneumoniae serotype 1 in Brazil: evidence of clonal replacement

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