Invasive Solid Papillary Carcinoma of Male Breast: A Rare Case Report

Abstract

Invasive papillary carcinoma of the breast is a rare form of breast carcinoma. Hereby we report a case of invasive papillary carcinoma of the breast in a 76-year-old otherwise healthy male, who presented at our department with the complaint of left subareolar masses. Mammography demonstrated two masses that were oval and round shaped, sharply demarcated and with micro calcifications on the internal structure. Ultrasonographic (US) analysis revealed solid mass lesions in the left subareolar location. These lesions had cystic areas in the interior structures. Color Doppler US revealed a high resistant vascularization in the central and peripheral parts of the lesions. Pathological examination of the specimen revealed the intracystic component to be invasive papillary carcinoma. In focal areas there was also findings of neuroendocrine differentiation. The patient underwent total mastectomy following an excisional biopsy, as the surgical margin after biopsy was positive for carcinoma. Axillary dissections had negative lymph nodes. After adjuvant chemotherapy and at the 2-year follow-up examination there were no recurrences or metastases. A high index of suspicion is necessary in male patients with solid lesions with cystic components.

Solid Papillary Carcinoma with Invasion in the Male Breast: A Case Report and Literature Review

“…The data that support the findings of this study are openly available in PubMed at "http:// doi.org/[doi]," reference number [1,[3][4][5][6][7][8][9][10][11][12][13][14][15].…”

“…Additionally, we checked case reports, clinical SPC studies, and the references cited in the original articles, excluding some articles whereby the authors confirmed other papillary neoplasms. Eleven male SPC cases have been identified, including our case [1,7,[9][10][11][12][13][14][15] (Table 1). These patients were relatively older, and most had a palpable mass.…”

Invasive Papillary Carcinoma of Male Breast – A Rare Case Report

“…In papillary carcinoma fibrovascular stroma is less conspicuous due to pronounced epithelial component proliferate in discontinuous fashion and have hyperchromatic nuclei, high nucleocytoplasmic ratio and variable mitotic figures [12] .Treatment of invasive papillary carcinoma varies according to staging and presence of hormone receptors. Lumpectomy and mastectomy is followed byadjuvant chemotherapy, radiotherapy and hormone therapy [13] . In our patient after mastectomy patient had undergone chemotherapy and radiotherapy and patient is doing well now.…”