Invasive Streptococcus pneumoniae isolates from pediatric population in Argentina for the period 2006–2019. Temporal progression of serotypes distribution and antibiotic resistance

Zintgraff, Jonathan; Gagetti, Paula; Napoli, Daniela; Eluchans, Nahuel Sánchez; Irazú, Lucía; Moscoloni, Maria Luisa; Regueira, Mabel; Corso, Alejandra

doi:10.1016/j.vaccine.2021.12.008

Cited by 18 publications

(15 citation statements)

References 42 publications

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“…The first compound, Compound 1 (Dipotassium piperazine-1,4-dicarbodithiate, LRS01-057), was synthesized. 1 H NMR (400 MHz, DMSO-d 6 ) δ 4.34 -4.22 (m, 4H), 3.51 -3.39 (m, 4H). 13 C NMR (100 MHz, DMSO-d 6 ) δ 215.02, 66.58, 50.01.…”

Section: Synthesis Of Dmdc Analogsmentioning

confidence: 99%

“…Following the general procedure, the title compound was synthesized in 57% as a white solid to Compound 2 (Sodium 4-(p-tolyl)piperazine-1-carbodithioate, LRS01-084) 1 H NMR (400 MHz, DMSO-d 6 ) δ 4.20 (s, 8H). 13 C NMR (100 MHz, DMSO-d 6 ) δ 214.14, 49.51.…”

Section: Synthesis Of Dmdc Analogsmentioning

confidence: 99%

“…Following the general procedure using NaOH as a base, the title compound was synthesized in 83% as a light yellow solid to synthesize Compound 3 (Sodium N-benzyl-Nmethyldithiocarbamate, LRS01-075) 1 H NMR (400 MHz, DMSO-d 6 ) δ 6.98 (d, J = 8.1 Hz, 2H), 6.80 (d, J = 8.2 Hz, 2H), 4.41 (t, J = 5.1 Hz, 4H), 2.96 (t, J = 5.1 Hz, 4H), 2.16 (s, 3H). 13 Following the general procedure using NaOH as a base, the title compound was synthesized in 73% as a white solid for Compound 4 (Sodium N-allyl-Nmethyldithiocarbamate, LRS01-077).…”

Section: Synthesis Of Dmdc Analogsmentioning

confidence: 99%

“…Streptococcus pneumoniae (also known as the pneumococcus) is a Gram-positive bacterium that is a leading cause of pneumonia, otitis media, meningitis, and sepsis. As such, the pneumococcus causes a significant disease burden in the pediatric and elderly populations despite effective vaccines against the most common strains (1). Normally a commensal of the nasopharynx and upper respiratory tract, the causes and gene regulation of pathogenic transformation is an ongoing topic of investigation (2).…”

Section: Introductionmentioning

confidence: 99%

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Compounds derived from N,N-dimethyldithiocarbamate are effective copper-dependent antimicrobials against Streptococcus pneumoniae

Johnson

Menghani

Sanchez-Rosario

et al. 2022

Preprint

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N,N-dimethyldithiocarbamate (DMDC) is a potent copper-dependent antimicrobial against several pathogens, including Streptococcus pneumoniae. Despite the availability of several vaccines against multiple disease-causing strains of S. pneumoniae, the rise of antimicrobial resistance and pneumococcal disease caused by strains not covered by the vaccine creates a need for developing novel antimicrobial strategies. We derived novel compounds from DMDC and tested their effectiveness as copper-dependent antimicrobials against S. pneumoniae through in vitro growth and killing curves. Compounds that caused a growth defect and were bactericidal in vitro were tested against other strains of S. pneumoniae and in complex with different transition metals. We found two compounds, sodium N-benzyl-N-methyldithiocarbamate and sodium N-allyl-N-methyldithiocarbamate (herein "Compound 3" and "Compound 4"), were effective against TIGR4, D39, and ATCC® 6303™ (a type 3 capsular strain) and further increased the internal concentrations of copper to the same previously reported levels as with DMDC and copper treatment. We found that both Compound 3 and Compound 4 were bacteriostatic in combination with zinc. We tested Compound 3 and Compound 4 in vivo against a murine pneumonia model, finding that Compound 3, and not Compound 4, was effective in significantly decreasing the bacterial burden in the blood and lungs of S. pneumoniae-infected mice. We found that the combination of Compound 3 and copper made the pneumococcus more susceptible to activated macrophage mediated killing via an in vitro macrophage killing assay. Collectively, we demonstrate that derivatizing DMDC holds promise as potent bactericidal antibiotics against S. pneumoniae.

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Section: Synthesis Of Dmdc Analogsmentioning

confidence: 99%

Section: Synthesis Of Dmdc Analogsmentioning

confidence: 99%

Section: Synthesis Of Dmdc Analogsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Compounds derived from N,N-dimethyldithiocarbamate are effective copper-dependent antimicrobials against Streptococcus pneumoniae

Johnson

Menghani

Sanchez-Rosario

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“… 2 It is colonized in the nasopharynx of healthy people, with the highest colonization rate in children, and can be transmitted through droplets and direct contact. 3 , 4 Streptococcus pneumoniae infection is the most important pathogen causing meningitis, community-acquired pneumonia, and otitis media in children. In addition, invasive pneumococcal diseases (IPDs) are the leading cause of death in children under 5 years of age.…”

mentioning

confidence: 99%

Changes in Streptococcus pneumoniae infection in children before and after the COVID-19 pandemic in Zhengzhou, China

Guo

Duan

2022

Journal of Infection

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High prevalence of 19A pneumococcal serotype carriage during the COVID-19 pandemic in Brazil

Primon-Barros,

Varela,

Polese-Bonatto

et al. 2024

The Brazilian Journal of Infectious Diseases

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Invasive Streptococcus pneumoniae isolates from pediatric population in Argentina for the period 2006–2019. Temporal progression of serotypes distribution and antibiotic resistance

Cited by 18 publications

References 42 publications

Compounds derived from N,N-dimethyldithiocarbamate are effective copper-dependent antimicrobials against Streptococcus pneumoniae

Compounds derived from N,N-dimethyldithiocarbamate are effective copper-dependent antimicrobials against Streptococcus pneumoniae

Changes in Streptococcus pneumoniae infection in children before and after the COVID-19 pandemic in Zhengzhou, China

High prevalence of 19A pneumococcal serotype carriage during the COVID-19 pandemic in Brazil

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