There is an increasing competition between companies for their survival in today's business environment. Not only time but also cost parameters affect the company's sustainability performance. Logistics as one of the core operations of companies has a large share on expenses. Transport, warehousing, administration, packaging, and other indirect costs constitute the main cost values of logistics. Especially product damages caused by incorrect packing and transportation leads to extra expenditures to the companies and damages their reputation due to the customer dissatisfaction. In order to avoid such situations, proper level of packaging for protection, transportation conditions, features of the product like fragility, compactness, must be selected and matched correctly. On the other hand, some external factors such as temperature and humidity, which affect the quality of cardboard, also need to be considered in the production phase. In this study, a Design of Experiment methodology is performed to determine the suitable conditions for increasing the strength of the corrugated cardboard box that is used by a Glassware Company operating in Turkey. 3 k full factorial design approach is implemented for the analysis and box compression test is used for measurement. The discussed factors and the interactions of the factors were evaluated with the help of Minitab software.