Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population

Abstract

Background Irisin is a novel myokine associated with obesity, which is a traditional cardiovascular risk factor (CVRF). The present study aimed to investigate the association between serum irisin and a single CVRF as well as the clustering of CVRFs among Chinese overweight/obese population. Methods A total of 98 overweight and 93 obese subjects without clinical treatments were enrolled in this study. Subjects were then divided into two groups, based on the serum irisin level: a low irisin group (1.10–13.44 ng/ml) and a high irisin group (13.49–29.9 ng/ml). The clustering of CVRFs, smoking, diabetes mellitus, dyslipidemia and hypertension, was classified as 0, 1, 2 and ≥ 3 CVRFs. The demographic and baseline clinical characteristics of all participants were collected and serum irisin was measured. Results The high serum irisin group had significantly higher high-density lipoprotein cholesterol but lower fasting plasma glucose than the low serum irisin group. Additionally, the high serum irisin group had a significantly lower prevalence of smoking, diabetes mellitus and dyslipidemia than the low serum irisin group. Increased serum irisin was significantly associated with a reduced risk of smoking and dyslipidemia in both the unadjusted and adjusted models. Furthermore, high serum irisin significantly reduced the risk of the prevalence of 1, 2 and ≥ 3 CVRFs. Conclusions among the Chinese overweight/obese populations, high serum irisin is negatively associated with smoking, dyslipidemia and the clustering of CVRFs. Thus, high serum irisin is potentially associated with a low risk of cardiovascular diseases in the Chinese overweight/obese population.

Exploring Irisin Levels in Patients with Endometrial Atypical Hyperplasia and Carcinoma: A Comparative Analysis

“…High Irisin levels have been found to be associated with better control of hypertension and T2DM in various studies. (21,22). Despite the diversity in our patient group regarding the presence of hypertension and T2DM, probably due to the effects of natural aging, regression analyses indicated that systemic disorders had no signi cant effect on Irisin levels among the patient population.…”

Association Between Triglyceride-Glucose Index and Serum Uric Acid Levels: A Biochemical Study on Anthropometry in Non-Obese Type 2 Diabetes Mellitus Patients

“…The subject inclusion criteria were as follows: 1) the diagnosis of T2DM was based on the latest American Diabetes Association guidelines for the diagnosis and treatment of diabetes; 36 2) all patients were aged ≥18 years and ≤80 years; 3) subjects had a body mass index (BMI) <28 kg/m 2 , which met the Chinese diagnostic standard for non-obesity. 37 …”

“…The subject inclusion criteria were as follows: 1) the diagnosis of T2DM was based on the latest American Diabetes Association guidelines for the diagnosis and treatment of diabetes; 36 2) all patients were aged ≥18 years and ≤80 years; 3) subjects had a body mass index (BMI) <28 kg/m 2 , which met the Chinese diagnostic standard for non-obesity. 37 The subject exclusion criteria were as follows: 1) individuals with other types of diabetes, including type 1 diabetes, gestational diabetes, and other specific types of diabetes; 2) patients with acute complications of diabetes, such as hyperosmolar hyperglycemic syndrome, ketoacidosis, and hypoglycemia; 3) patients with a history of chronic kidney disease, severe hepatic or renal insufficiency, and those undertaking a uric acid-lowering therapy; 4) patients with severe cardiac diseases, acute cerebrovascular diseases, tumor, and psychosis.…”

Organokines, Sarcopenia, and Metabolic Repercussions: The Vicious Cycle and the Interplay with Exercise

“…At low levels, this molecule also leads to increased insulin resistance [ 68 ]. Among Chinese individuals, Liu et al [ 69 ] found in a cross-sectional study that serum irisin levels are inversely correlated with dyslipidemia. Lack of exercise is the main cause of lower irisin levels, which connects intimately with protein and muscle mass loss in the occurrence of sarcopenia.…”

“…Fetuin-A has been shown to have a high association with non-alcoholic fatty liver disease. This metabolic pattern occurs by virtue of the increase in the amounts of fetuin-A interfering with the insulin signaling cascade and the translocation of GLUT-4 in the insulin target tissues and, as a consequence, causing damage to the pancreatic β cells [ 69 , 100 , 101 ].…”