Inverse relationship between vitamin D levels and platelet indices in Korean adults

Park, Yon Chul; Kim, Jin; Seo, Min Seok; Hong, Seokmin; Cho, Eun Seok; Kim, Jong Koo

doi:10.1080/10245332.2017.1318334

Cited by 35 publications

(33 citation statements)

References 37 publications

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“…Our data show, for the first time, that subjects with lower 25(OH)D levels have higher platelet numbers, indicating that a vitamin D deficiency in obese subjects may be predictive of a higher risk of inflammation, thrombosis and cardiovascular events in this condition. These results are in line with previous findings by Park and colleagues, that showed an inverse association between 25(OH)D levels and platelet indices in the general adult population but did not investigate possible differences between healthy and unhealthy subjects [19]. To better explain the interrelationship between obesity, vitamin D, platelet count and cardiovascular risk, it is of note that vitamin D has a direct role in regulating hematopoietic cells' differentiation [21].…”

Section: Discussionsupporting

confidence: 91%

“…People affected by diabetes [15,16], coronary artery disease [17], endothelial dysfunction or Sjögren's syndrome [18], which are all triggering conditions for inflammation and higher levels of inflammatory markers, have been described to exhibit poor vitamin D status. However, Park et al recently showed an inverse association between 25(OH)D levels and platelet count in the general adult population, although they did not investigate possible differences between healthy and unhealthy subjects [19]. There is no information about whether this association exists in overweight subjects.…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyvitamin D Serum Levels are Negatively Associated with Platelet Number in a Cohort of Subjects Affected by Overweight and Obesity

et al. 2020

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Background: Hypovitaminosis D and higher platelet numbers are emerging as cardiovascular risk factors, in particular in obese subjects. Methods: This observational study was aimed at investigating the relationship between platelet number and serum 25-hydroxyvitamin D (25(OH)D) levels in a cohort of individuals affected by overweight and obesity (body mass index (BMI) ≥ 25 Kg/m2). A sample of 341 subjects (248 women, 93 men), aged 18–71 years, taking no medication, was examined. Anthropometric, hormone, metabolic and common routine hematochemical parameters were examined and evaluated in association with platelet count and serum 25(OH)D levels. Results: Platelet numbers were inversely related to age (p < 0.04), 25(OH)D (p < 0.05) and uric acid (p < 0.04) levels, and directly associated with white blood cells (p < 0.01), Thyroid Stimulating Hormone (TSH) (p < 0.04), insulin levels (p < 0.002) and Homeostasis Model Assessment – Insulin Resistance (HOMA-IR) (p < 0.002). We applied statistical regression models to examine the relationship between platelet count (dependent variable) and parameters that had univariate associations with platelet numbers, showing that the association between platelet count and 25(OH)D was not confirmed. Moreover, vitamin D showed a negative independent association with BMI, diastolic blood pressure and serum insulin levels. Conclusions: This study indicates, for the first time, that vitamin D deficiency is associated with a parallel increase in platelet number, suggesting that higher platelet numbers may be one of the possible mechanisms leading to a greater cardiovascular risk in obese subjects. It also shows that vitamin D deficiency, a common condition in obesity, has independent associations with higher BMI, diastolic blood pressure and serum insulin levels.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Hydroxyvitamin D Serum Levels are Negatively Associated with Platelet Number in a Cohort of Subjects Affected by Overweight and Obesity

et al. 2020

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“…7 Previously, few studies investigated direct associations between vitamin D concentrations and platelet parameters in health and disease. [35][36][37][38][39][40] Verdoia et al reported an association between low vitamin D concentrations and high-residual platelet reactivity in patients with cardiovascular diseases receiving dual antiplatelet therapy, 35 and similarly this was shown in patients with diabetes. 38 Moreover, in hemodialysis patients vitamin D supplementation resulted in antithrombotic effects.…”

Section: Discussionmentioning

confidence: 77%

Platelet Integrin αIIbβ3 Activation is Associated with 25-Hydroxyvitamin D Concentrations in Healthy Adults

et al. 2020

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Background Cardiovascular events are associated with low circulating vitamin D concentrations, although the underlying mechanisms are poorly understood. This study investigated associations between 25-hydroxyvitamin D concentrations, platelet function, and single-nucleotide polymorphisms (SNPs) in genes influencing vitamin D biology in the 500 Functional Genomics (500FG) cohort. Methods In this observational study, platelet activation and function were measured by flow cytometry by binding of fibrinogen to the activated fibrinogen receptor integrin αIIbβ3 and expression of P-selectin, markers of platelet aggregation and degranulation, respectively. These parameters were correlated to serum 25-hydroxyvitamin D and genotyping was performed to investigate SNPs in genes important for vitamin D biology. Results Circulating 25-hydroxyvitamin D concentrations correlated inversely with baseline platelet binding of fibrinogen to integrin αIIbβ3 (Pearson's r= –0.172, p = 0.002) and platelet responses to platelet agonist cross-linked collagen-related peptide (CRP-XL) (Pearson's r= –0.196,p = 0.002). This effect was due to circulating vitamin D levels ≤50nmol/L, since no differences in platelet fibrinogen binding were observed between subjects with normal 25-hydroxyvitamin D concentrations (>75nmol/L) and a 25-hydroxyvitamin D insufficiency (50–75 nmol/L). No correlations between 25-hydroxyvitamin D concentrations and platelet P-selectin expression were found. Several SNPs in the GC region of the vitamin D binding proteingene were associated with platelet responses to CRP-XL. Conclusion Low circulating vitamin D concentrations are associated with increased platelet fibrinogen binding to integrin αIIbβ3 in unstimulated samples and after stimulation with CRP-XL. These findings may contribute to the increased incidence of cardiovascular events in vitamin D deficient adults and its seasonal variation. Further studies are needed to investigate causality.

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“…The evidence suggests that patients with vitamin D deficiency have a higher MPV and therefore a greater risk of vascular disease. Indeed, Parker and colleagues showed that vitamin D deficient patients had significantly higher MPV than those with adequate 25(OH)D 3 D3 levels [35]. Similarly, Korzonek-Szlacheta and colleagues found that the MPV in patients with 25(OH)D 3 levels >20 ng/mL was lower than that in patients with 25(OH)D 3 levels <10 ng/mL and in patients with 25(OH)D 3 levels comprised between 10 and 20 ng/mL [36].…”

Section: Discussionmentioning

confidence: 99%

Is There an Association Between Vitamin D Deficiency and Erectile Dysfunction? A Systematic Review and Meta-Analysis

et al. 2020

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Erectile dysfunction (ED) is found very frequently in the male population, in particular in its arteriogenic form, which also represents an important predictor of cardiovascular diseases (CVDs). Some evidence suggests that vitamin D could play a role in cardiovascular risk prevention thanks to its ability to reduce endothelial damage, oxidative stress, the production of inflammatory cytokines, and dyslipidemia. Since ED and CVDs have pathogenic mechanisms in common, numerous studies have evaluated a possible association between vitamin D deficiency (blood concentrations of 25-hydroxyvitamin D < 20 ng/mL) and ED, but with conflicting results. This meta-analysis was therefore performed to clarify the discrepancy of the data so far published. To achieve this, articles have been searched extensively in the Pubmed, MEDLINE, Cochrane, Academic One Files, Google Scholar, and Scopus databases from the first day they were created until January 2020. The search strategy included pertinent Medical Subjects Headings (MeSH) terms. Of the 431 items retrieved, only eight observational studies were included, resulting in a total sample size of 4055 patients. It was found that 25-hydroxyvitaminD (25(OH)D) levels did not show any significant difference between patients with and without ED. However, when patients with vitamin D deficiency only were taken into account, the international index of erectile function (IIEF) score for erectile dysfunction was significantly worse than in controls. This association remained significant even when eugonadal-only patients were considered. Finally, we found that eugonadal patients with severe ED have lower 25(OH)D3 levels than patients with mild ED. In conclusion, this meta-analysis suggests an association between vitamin D deficiency and the presence of severe forms of ED, independent of testicular function.

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Inverse relationship between vitamin D levels and platelet indices in Korean adults

Abstract: PC and MPV are inversely associated with vitamin D levels in adults.

Cited by 35 publications

References 37 publications

Hydroxyvitamin D Serum Levels are Negatively Associated with Platelet Number in a Cohort of Subjects Affected by Overweight and Obesity

Hydroxyvitamin D Serum Levels are Negatively Associated with Platelet Number in a Cohort of Subjects Affected by Overweight and Obesity

Platelet Integrin αIIbβ3 Activation is Associated with 25-Hydroxyvitamin D Concentrations in Healthy Adults

Is There an Association Between Vitamin D Deficiency and Erectile Dysfunction? A Systematic Review and Meta-Analysis

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