Investigação da LMP1 do EBV e a coinfeçcão do HPV em lesões genitais de pacientes infectados ou não pelo HIV

Rodrigues, Fabiana Resende; Miranda, Nilcimar Lourenço; Fonseca, Elize Massard da; Pires, Andrea; Dias, Eliane Pedra

doi:10.1590/s1676-24442010000500011

Cited by 5 publications

(3 citation statements)

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“…Our rate of anal STDs are similar to the findings of Sobhani et al 26 , who described an 8% rate of EBV coinfection, a 12% rate of CMV anal infection and a 24% rate of HSV anal infection. However, this study found lower prevalence of EBV (7.7%) and CMV (1.5%) infection compared to the findings of Löwhagen et al 27 and Rodrigues et al 9 , who reported a prevalence of HSV and EBV of over 30%. Because we used RT-PCR as a means of diagnosis, and the method is known to be higher than conventional PCR and the culturing of samples 28 ; therefore, we do not consider our results to be contradictory with previous findings, but as features of our study population.…”

Section: Vol 32contrasting

confidence: 85%

“…The presence of HSV-EBV coinfection as a risk factor for the development of anal cancer among patients of both sexes coinfected with HPV-HIV has already been described [9][10][11] . In the present study, we report five cases of coinfection with EBV.…”

Section: Vol 32mentioning

confidence: 99%

“…The presence of coinfections appears to increase the risk of HPV-infected cells progressing to malignancy. These pathogens act synergistically to induce anogenital epithelial lesions, particularly in HIV-positive patients 9 . The Epstein-Barr virus (EBV) infection has also been studied in genital warts and perianal intraepithelial lesions for which the role of synergism in the etiology of cancer has also suggested 10,11 .…”

Section: Introductionmentioning

confidence: 99%

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Coinfection of Epstein-Barr virus, cytomegalovirus, herpes simplex virus, human papillomavirus and anal intraepithelial neoplasia in HIV patients in Amazon, Brazil

Guimarães¹,

Araújo²,

Andrade³

et al. 2012

J. Coloproctol. (Rio J.)

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OBJECTIVE: The prevention of anal cancer is a goal of worldwide Aids support centers. Despite the efforts that have been made and progress in the antiretroviral therapy, effective disease control remains elusive. Difficulty in preventing anal cancer may result from the ineffectiveness of highly active antiretroviral therapy on the human papillomavirus (HPV) since the coinfection with HIV and HPV appears to increase the risk of HPV-infected cells, becoming cancerous. METHODS: We evaluated 69 HIV-positive and 30 HIV-negative male patients who underwent cytological evaluation by RT-PCR for the presence of HPV, Epstein-Barr virus, cytomegalovirus and herpes virus types (HSV) 1 and 2, and histopathology analysis of the anal canal. RESULTS: The prevalence of anal intraepithelial neoplasia was 35% and it was restricted to HIV-positive patients. Patients infected with high-risk HPV and with fewer than 50 TCD4 cells/µL showed an anal intraepithelial neoplasia rate of 85.7% compared to those with TCD4 cells >200 cells/µL (p<0.01). The rate of viral coinfection was 16.9% of the sexual transmitted diseases cases and it was correlated with HIV-1 viral load of more than 10.001 copies/mL (p=0.017). The rate of AIN in coinfected patients was 36.4% (p=0.047). CONCLUSIONS: In this study, at the main institution for the treatment of HIV/AIDS in the Amazon region of Brazil, anal coinfection with HPV, cytomegalovirus, HSV-1, HSV-2 and Epstein-Barr virus occurred only in HIV-positive patients and it was directly influenced by the viral load of HIV-1. In this study, anal viral coinfection showed no additional risk for the development of anal intraepithelial neoplasia.
OBJETIVO: A prevenção do câncer anal tem sido aplicada pelos centros de apoio a pacientes com Aids em todo o mundo. Apesar dos esforços empregados, o eficaz controle da doença permanece distante. A dificuldade na prevenção do câncer anal pode resultar, em parte, da ineficácia da ação da terapia antirretroviral sobre o papilomavírus humano (HPV), pois a coinfecção com HIV e HPV parece aumentar o risco das células infectadas pelo HPV em tornarem-se cancerosas. MÉTODOS: Foram avaliados 69 HIV-positivos e 30 pacientes HIV-negativos do sexo masculino, que foram submetidos à avaliação citológica anal por real time-PCR para a presença de HPV, vírus Epstein-Barr, citomegalovírus e herpes vírus tipos (HSV) 1 e 2 além da análise histopatológica de fragmento de mucosa do canal anal. RESULTADOS: A prevalência de neoplasia intraepitelial anal foi de 35% e foi restrita a pacientes HIV-positivos. Os pacientes infectados com o HPV de alto risco e com contagem inferior a 50 células TCD4/µL mostraram taxa de neoplasia intraepitelial anal de 85,7%. A diferença foi significativa quando comparado a pacientes com células TCD4 >200 células/µL (p<0,01). A taxa de coinfecção viral foi de 16,9% dos casos de doenças sexualmente transmissíveis e diretamente correlacionada à carga viral HIV-1 superior a 10,001 cópias/mL (p=0,017). A taxa de neoplasia intraepitelial anal em pacientes coinfectados f...

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Section: Vol 32contrasting

confidence: 85%

Section: Vol 32mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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