Investigating genetic polymorphism in E. histolytica isolates with distinct clinical phenotypes

Genetic characterization of the Entamoeba moshkovskii population based on different potential genetic markers

“…Moreover, it has been documented in non-human primates as well (Levecke et al, 2010). A study conducted in eastern India by Sardar et al (2023aSardar et al ( , 2023b) also revealed that E. moshkovskii is one of the causative agents of diarrhoeal incidents in humans. The research found that many patients suffering from diarrhoea, infected with E. moshkovskii, tested negative for other common enteric pathogens such as bacteria and viruses (Sardar et al, 2023a(Sardar et al, , 2023b.…”

“…A study conducted in eastern India by Sardar et al (2023aSardar et al ( , 2023b) also revealed that E. moshkovskii is one of the causative agents of diarrhoeal incidents in humans. The research found that many patients suffering from diarrhoea, infected with E. moshkovskii, tested negative for other common enteric pathogens such as bacteria and viruses (Sardar et al, 2023a(Sardar et al, , 2023b. These findings, combined with various studies conducted in different regions, suggest the potential pathogenicity of E. moshkovskii in humans.…”

“…Although, E. moshkovskii has demonstrated pathogenicity, not all genotypes within the species are linked to diarrhoeal incidence, similar to E. histolytica, where only 10% of infections exhibit pathogenicity (Sardar et al, 2023a(Sardar et al, , 2023b. Hence, it is essential to conduct genotyping of E. moshkovskii to accurately identify its pathogenic genotypes.…”

“…Hence, it is essential to conduct genotyping of E. moshkovskii to accurately identify its pathogenic genotypes. In our earlier study, we have identified some significant single-nucleotide polymorphisms (SNPs) that were linked to clinical outcomes (Sardar et al, 2023a(Sardar et al, , 2023b. However, it is important to note that the correlation between SNPs and clinical features does not necessarily mean that they directly impact pathogenicity (Sardar et al, 2023a(Sardar et al, , 2023b.…”

“…In our earlier study, we have identified some significant single-nucleotide polymorphisms (SNPs) that were linked to clinical outcomes (Sardar et al, 2023a(Sardar et al, , 2023b. However, it is important to note that the correlation between SNPs and clinical features does not necessarily mean that they directly impact pathogenicity (Sardar et al, 2023a(Sardar et al, , 2023b. While genotyping using 18S rRNA is essential in phylogenetic analysis, it does not directly affect pathogenicity.…”